ABSTRACT
Paste "Zdorovie", a product with high content of protein and assimilable iron, developed at the Moscow Institute of Applied Biotechnology, has been proved to be effective in the combined antianemia therapy. Improved hemograms and biochemical parameters were recorded in 60 pregnant women and nursing mothers suffering from iron-deficiency anemia (IDA). The data obtained have permitted the authors to recommend paste "Zdorovie" for combined treatment of IDA in pregnant women and to consider it promising in prevention of IDA in nursing mothers.
Subject(s)
Anemia, Hypochromic/diet therapy , Breast Feeding , Food, Fortified , Pregnancy Complications, Hematologic/diet therapy , Adult , Female , Humans , PregnancyABSTRACT
Young rats aged 14 days were subjected to malnutrition during 3.7 and 14 days. Activity of the main microsomal enzymes and lipid peroxidation (LPO) products in the microsomal cytosol fraction of the liver was studied in the test and control (aged 17.21 and 28 days) animals. It has been found that constant malnutrition leads to elevation of amidopyrine demethylase activity and inhibition of c-reductase and aniline hydrolase NADP.H cytochrome activities, as well as to a decreased content of protein and cytochrome P-450 in the liver. At the same time the levels of conjugated dienes and diene-ketones in the microsomal-cytosol fraction of the liver significantly rise that denotes activation of LPO in the microsomal membranes. It has been suggested that the suppression of the monooxygenase system function during malnutrition induces inhibition of the intensity of biotransformation of xenobiotics, including drugs which is responsible for intensification of pharmacodynamics and toxicity of the latter. These conditions should be taken into consideration during drug therapy in patients with malnutrition.
Subject(s)
Aging/metabolism , Microsomes, Liver/enzymology , Nutrition Disorders/enzymology , Oxygenases/metabolism , Animals , Female , Growth , Lactation , Lipid Peroxidation , Pregnancy , Rats , Time FactorsABSTRACT
The antianemic effect of a multicomponent sausage product was studied in the experiment on noninbred male white rats (4 groups of animals, 10 rats in each), the experiment continued 90 days. The stimulatory effect of this product on hemopoiesis was recorded both in the test animals (with anemia) and controls (with no anemia), that was, obviously, connected with the inclusion of by-products of animal origin into the new sausage product, which are characterized by high levels of hemostimulatory factors.
Subject(s)
Anemia/diet therapy , Meat Products , Meat , Anemia/blood , Animals , Dietary Fats/administration & dosage , Dietary Proteins/administration & dosage , Male , Rats , Trace Elements/administration & dosageSubject(s)
Anemia, Hypochromic/diet therapy , Food, Fortified , Meat Products , Meat , Pregnancy Complications, Hematologic/diet therapy , Adult , Animals , Cattle , Dietary Carbohydrates/administration & dosage , Dietary Fats/administration & dosage , Dietary Proteins/administration & dosage , Female , Humans , Iron/administration & dosage , PregnancyABSTRACT
New types of sausages intended for the pregnant and lactating mothers suffering from anemias were assessed from the medical and biological standpoints at the Almalyk and Tashkent meat-packing plants. Subject to examination were 3 versions of new experimental sausages. Doktorskaya sausage was used as control. The physicochemical and amino acid composition of sausages is described. The sausage was found to be rich in all the nutrients which are necessary for anemic women. The amino acid composition of sausages was determined relative to the reference FAO/WHO scale. The biological value was determined in male Wistar rats. Experimental sausages were found to be high-protein products containing 19.6 mg/100 ml iron, 64 micrograms/100 ml copper and 9.5 micrograms/100 ml cobalt. Thus, these sausages may be included into the diet of the pregnant and lactating mothers suffering from anemias.
