The accuracy of external calibration markers in digital templating using the double marker and single marker method: a comparative study.

BACKGROUND: Digital templating is an essential step in the preoperative planning of total hip arthroplasty (THA). Previous studies have suggested that templating with the double marker method may be more accurate than a single marker method in the general population and in obese patients. The purpose of this study was to compare the accuracy in the preoperative component selection between the King Mark calibration device and the conventional metal ball method. Additionally, we examined whether King Mark offered any advantage over the standard metal ball in the preoperative selection of component sizes for obese patients. METHODS: We retrospectively reviewed patients who underwent preoperative digital templating for THA in our center from January 2014 to January 2016 with King Mark device and marker ball. We compared the preoperative template component size and offset with the intraoperative definite implant size. The accuracy was defined as the difference between preoperative and intraoperative component sizes. The overall accepted calibration was defined as an exact match ± one size. Patients were stratified into two cohorts according to the calibration method: standard marker ball technique and King Mark technique. RESULTS: 126 THA underwent digital calibration. 79 patients underwent a preoperative templating using the King Mark calibration device. 47 patients were templated using a conventional marker ball. The overall adequate preoperative planning of the acetabular cup (exact or ± 1 size match) in the King Mark group did not differ from the single marker method (74.7% and 74.5%, respectively, p = 0.979). No significant difference was noted in the overall accepted calibration of the femoral stem (exact or ± 1 size match) between the marker ball group and the King Mark group (58.2% and 70.2%, respectively, p = 0.179). The King Mark group showed a better preoperative planning for the stem's offset compared to the marker ball group (77.2% % and 61.7%, respectively, p = 0.062). For the obese patient cohort, no significant difference was noted between the King Mark group and the marker ball group in the exact prediction of the acetabular cup and the femoral stem, (p = 0.31 and p = 0.15, respectively). CONCLUSIONS: Our study found no difference between the King Mark method and the conventional metal ball method in the ability to accurately predict component sizes. In the subgroup of obese patients, the King Mark technique offered no advantage for accurately predicting component sizes.

Bedside risk estimation of morbidly adherent placenta using simple calculator.

PURPOSE: To construct a calculator for 'bedside' estimation of morbidly adherent placenta (MAP) risk based on ultrasound (US) findings. MATERIALS AND METHODS: This retrospective study included all pregnant women with at least one previous cesarean delivery attending in our US unit between December 2013 and January 2017. The examination was based on a scoring system which determines the probability for MAP. RESULTS: The study population included 471 pregnant women, and 41 of whom (8.7%) were diagnosed with MAP. Based on ROC curve, the most effective US criteria for detection of MAP were the presence of the placental lacunae, obliteration of the utero-placental demarcation, and placenta previa. On the multivariate logistic regression analysis, US findings of placental lacunae (OR = 3.5; 95% CI, 1.2-9.5; P = 0.01), obliteration of the utero-placental demarcation (OR = 12.4; 95% CI, 3.7-41.6; P < 0.0001), and placenta previa (OR = 10.5; 95% CI, 3.5-31.3; P < 0.0001) were associated with MAP. By combining these three parameters, the receiver operating characteristic curve was calculated, yielding an area under the curve of 0.93 (95% CI, 0.87-0.97). Accordingly, we have constructed a simple calculator for 'bedside' estimation of MAP risk. The calculator is mounted on the hospital's internet website ( http://www.assafh.org/Pages/PPCalc/index.html ). The risk estimation of MAP varies between 1.5 and 87%. CONCLUSIONS: The present calculator enables a simple 'bedside' MAP estimation, facilitating accurate and adequate antenatal risk assessment.

Donor hemosiderosis does not affect liver function and regeneration in the setting of living donor liver transplantation.

Living donor liver transplantation (LDLT) demands a careful assessment of abnormal findings discovered during the evaluation process to determine if there will be any potential risks to the donor or recipient. Varying degrees of elevated hepatic iron levels are not uncommonly seen in otherwise healthy individuals. We questioned whether mild expression of hemosiderin deposition presents a safety concern when considering outcomes of living donation for both the donor and the recipient. We report on three LDLT patients who were found to have low- to moderate-grade hemosiderin deposition on liver biopsy. All other aspects of their evaluation proved satisfactory, and the decision was made to proceed with donation. There were no significant complications in the donors, and all demonstrated complete normalization of liver function postoperatively, with appropriate parenchymal regeneration. The recipients also had unremarkable postoperative recovery. We conclude that these individuals can be considered as potential donors after careful evaluation.

Hydrometrocolpos--diagnostic and therapeutic dilemmas.

Congenital distal vaginal obstruction is a rare condition, usually asymptomatic until menarche, thus often diagnosed only during puberty. Hydrometrocolpos is caused by such an obstruction, only when reasonable amounts of fluid are secreted from the mucosal lining of the genital tract. This presentation may be symptomatic and already diagnosed early in life, even during the perinatal period. There are various causes of congenital vaginal obstruction, and according to their etiology, surgical procedures may be either simple or more complicated. Timing of the surgical procedure for opening the obstruction is a dilemma. We suggest postponing the definite procedure to the menarche, when hematocolpos (accumulation of blood in the vagina) will develop, but before the further development of hematometra (accumulation of blood in the uterine cavity). This will cause stretching of the obstructed segment, will enable correct diagnosis, facilitate the procedure, and eventually minimize the complications. However, if the vaginal obstruction in neonates or in childhood is symptomatic, as in the described case, aspiration of the fluid and temporary release of the symptoms should be the optimal choice, followed by a final surgical correction latter in life.

Immunoglobulins A, G, and M to cytomegalovirus during recurrent infection in recipients of allogeneic bone marrow transplantation.

Occurrence and significance of specific IgA and IgM to cytomegalovirus (CMV) in recurrent CMV infection was evaluated in 21 allogeneic T lymphocyte-depleted bone marrow transplantation (BMT) recipients who had been previously CMV seropositive. Of 17 patients with CMV infection, viruria was detected in 94%, CMV-specific IgA in 88% and IgM in 76%, and a fourfold rise in IgG in 65%. The median time between BMT and detection of viruria was 69 days, of IgA 70, of IgM 62, and of IgG 88 days. The IgM and IgA responses lasted for 14 and 30 days (median time), whereas high IgG titers persisted. Twelve patients developed CMV disease; in these the appearance of viruria, IgA, and IgM preceded the rise of IgG (P less than .02). CMV-specific IgA and IgM are valuable diagnostic tools in BMT recipients with recurrent CMV infection.

Detecting Chlamydia trachomatis in men with urethritis: serology v isolation in cell culture.

The accuracy of single serovar (L2) inclusion immunoperoxidase assay (IPA) to show serum IgG and IgA antibodies specific to chlamydiae was compared with culture for Chlamydia trachomatis to diagnose chlamydial infection in 73 men with acute urethritis. C trachomatis only was isolated from 18 (25%), Neisseria gonorrhoeae only from 17 (23%), and both organisms from six (8%). Thus 24 (33%) yielded chlamydiae. Assays based on IgG antibodies to chlamydiae at a titre of 1/64 or more showed high sensitivity (96%) and a good negative predictive value (80%), but low specificity (13%) and agreement (48%) compared with culture. IgG antibodies to chlamydiae at a titre of 1/128 or more showed lower sensitivity (75%) but higher specificity (72%), negative predictive value (79%), and agreement (73%). IgA antibodies to chlamydiae at a titre of 1/8 or more showed a sensitivity of 88%, specificity of 72%, negative predictive value of 88%, and agreement of 79%. An appreciable (fourfold or more) decrease in IgA and IgG titres was observed in most (10) of the 15 men from whom second blood samples were obtained one to two years after treatment. Measuring specific IgA and IgG antibodies to chlamydiae by IPA may serve as a useful complementary test for diagnosing and following up patients with urethritis.