[The dynamics of endogenic intoxication in patients with extensive burns].

The sampling consisted of 22 patients with extensive burns with total affected area from 20% to 84% of body surface and with deep burns area from 10% to 40%. The suppurative complications in the form of sepsis were diagnosed in 10 and the transitory bacteremia in 12 victims. The total and effective concentration of albumin, the content of medium molecular peptides in dynamics at 1-3, 7, 14 and 21 days from the moment of trauma were detected to objectively evaluate the endogenic intoxication. The degree of intensity of endogenic intoxication was studied using such integral indicator as effective utilization factor In patients with extensive burns the endogenic intoxication was diagnosed on the basis of total and effective concentration of albumin and increase of content of medium molecular peptides. However the detection of endogenic intoxication of the basis of effective utilization factor is a more informative as compared with the analysis of these indicators separately and, hence, it promote the prescription of more appropriate disintoxication therapy its effectiveness evaluation including.

[Medicosocial aspects of thermal injuries in patients with hemocontact viral infection].

The social structure of patients of the burns unit in 2008 year, hospitalized with hemocontact viral infections (HVI), was analyzed. 764 patients were treated, HVI was diagnosed in 103 of them. Men had HVI two times more often then women. The possibility of HVI was higher in patients with fire burns. The lager the burn area was, the higher was the possibility of HVI detection. Patients with HVI were reliably younger with average age of 33.1 years; the majority of them were unemployed. The most socially problematic group was represented by patients with mixed HVI--unemployed youngsters of the capable age, the majority of them were drug addict.

[Lipid peroxidation and antioxidant system in inhalation injury]. / Perekisnoe okislenie lipidov i antioksidantnaia sistema pri ingaliatsionnoi travme.

Thirty-five patients (aged 45 +/- 2.0 years) with isolated inhalation injury were examined on days 1, 3, and 7 after the injury, Serum concentrations of lipid peroxidation (LPO) products (dienic conjugates, malonic dialdehyde, and degree of lipid oxidation) were increased in all terms of investigation. Studies of the antioxidant system (AOS) showed a decrease in endogenous alpha-tocopherol during all terms, while ceruloplasmin content gradually increased. LPO/AOS imbalance was the most expressed on day 7 after the injury, which indicates intensification of LPO processes in the victims. The results pathogenetically validate the use of antioxidants in combined therapy of patients with inhalation injuries. LPO/AOS imbalance should be evaluated in these patients.

[Role of B.A. Petrov in foundation and development of free flap skin transplantation problem]. / Rol' B.A.Petrova v stanovlenii i razvitii problemy svobodnoi peresadki kozhi.

The article reviews the history of development of free-flap skin transplantation and basic role of acad. B.A. Petrov who was the first to show the role of dermatom skin transplantation in vast granulating wounds as the only method saving the life of patients with severe burns. He also suggested to solve an actual problem--deficiency of resources of donor skin--by repeated excision of skin flaps from previously used donor sites and use of cadaver skin. Very important is ales the role of B.A. Petrov in development of such particular questions as the role of patient's condition, wound bed am microbial flora of the wound in survival of skin transplants. In aspect of historical relationships the perspective of new approach to treatment of deep burns by transplantation of ceratinocytes, cultivated outside the patient's organism is shown.