[Problem of the systematics of schizophrenia in light of current clinico-catamnestic, epidemiologic and clinico-genealogic information]. / K probleme sistematiki shizofrenii v svete sovremennykh kliniko-katamnesticheskikh, épidemiologicheskikh i kliniko-genealogicheskikh dannykh.

On the basis of the results provided by clinical follow-up, clinico-epidemiological and clinico-genealogical studies, the authors have reviewed the systematics of the major forms of schizophrenia developed at the Institute of Psychiatry of the USSR Academy of Medical Sciences and offer a statistical characteristics of these forms. The authors specifically discussed the questions associated with the characteristics of the syndrome formation and course of slowly progressive (torpid) schizophrenia and the place these forms occupy in the modern foreign classifications, including the DCM-III). The paroxysm-like form was established to run predominantly the course with a small rate of attacks or the "one-paroxysm" course. Slowly progressive and psychotic forms of continuous schizophrenia were shown to be relatively continuous, being characterized by not only the signs of tortuosity of the course but also by those of regression and subsidence of the process. Attention is drawn to the necessity of special elaboration of the notion "residual schizophrenia". All these postulates are illustrated by the appropriate statistical population characteristics.

[Risk of schizophrenic spectrum psychoses among the offspring of affected mothers and fathers (comparative epidemiologic study)]. / Risk zabolevaemosti psikhozami shizofrenicheskogo spektra v potomstve bol'nykh materei i ottsov (sravnitel'noe épidemiologicheskoe issledovanie).

Comparative epidemiological study in population of patients with schizophrenia in one of the Moscow regions revealed differential morbidity risk in posterity. Convincing proofs obtained showed sick children with schizophrenia prevalence in sick mothers, but not fathers' posterity. Such a conclusion on the representative populational material was made for the first time. The study showed the specificity of differential morbidity risk in control groups of patients with other disease entities analyzed. Different factors significance in so-called "maternal effect" manifestation are discussed.

[Genotypic specificity of schizophrenic psychoses]. / K voprosu o genotipicheskoi spetsifichnosti shizofrenicheskikh psikhozov.

A total of 610 probands with a disease manifestation in childhood, middle and old age and their families were examined by the clinico-genealogical method. The results allowed conclusions that (1) there is an undoubted genetic relationship between schizophrenia of childhood, middle and old age; and that (2) among the closest relatives in families of the probands there is no significant (in comparison to the general population) accumulation of non-schizophrenic pathology. The latter indicates a high genotypic specificity of schizophrenia.