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1.
Ross Fiziol Zh Im I M Sechenova ; 91(1): 46-52, 2005 Jan.
Article in Russian | MEDLINE | ID: mdl-15773579

ABSTRACT

Influence of a high-molecular compound capable of augmenting viscosity, namely: polyethylene oxide Polyox WSR-301, on hemodynamic parameters in rat mesenteric microvessels was investigated. A substantial decrease in the arteriolar hemodynamic resistance caused by the polymer was revealed. Special research has shown that this reaction is not connected with a vasodilatation and, therefore, is caused by a reduction in the "apparent" viscosity of the blood, i.e., it is a consequence of changed properties of the blood flow.


Subject(s)
Blood Viscosity/drug effects , Intestines/blood supply , Polyethylene Glycols/pharmacology , Animals , Blood Flow Velocity/drug effects , Hemorheology , Male , Mesenteric Arteries/physiology , Mesenteric Veins/physiology , Microcirculation/drug effects , Rats , Rats, Wistar , Vascular Resistance/drug effects
4.
Aviakosm Ekolog Med ; 32(1): 77-9, 1998.
Article in Russian | MEDLINE | ID: mdl-9606520

ABSTRACT

High-molecular polymers apt to directly influence flow microstructure were tested as a fundamentally new method for correcting microhemodynamics in microgravity. Pressure in the mesenteric arterial microvessels was measured two weeks in rats adapted to the head-down suspension. Intravenous polyethylene oxide (Polyox WSR-301, end-concentration in the order of 2.10(-7) g/ml), reduced the microvascular pressure by 26%, whereas in the control pressure was reduced by only 15%. Systemic arterial pressure showed an equal drop in the groups (by 10 to 11%). These results suggest that the biomechanical agent weakens resistance to the blood flow in the body region where blood supply is impaired by microgravity.


Subject(s)
Adaptation, Psychological , Hypotension, Orthostatic , Mesenteric Arteries/drug effects , Polyethylene Glycols/pharmacology , Polymers/pharmacology , Animals , Hemodynamics/drug effects , Rats , Time Factors , Weightlessness
9.
Usp Fiziol Nauk ; 26(2): 31-43, 1995.
Article in Russian | MEDLINE | ID: mdl-7785309

ABSTRACT

An analysis of the hemodynamic consequences of the injections of long linear polymers with high molecular weight is introduced. These injections lead to an increase of the cardiac output, to a decrease of the blood pressure, and hence cause a reduction of the resistance to blood flow. It follows that such kind of polymers is able to normalize hemodynamics under some pathophysiological conditions, e.g., during experimental atherosclerosis, ischemic state, hemorrhagic shock. An addition of drag-reducing polymers into the blood system is associated with a modification of the blood flow microstructure itself.


Subject(s)
Blood Circulation/drug effects , Polymers/pharmacology , Animals , Blood Circulation/physiology , Hemodynamics/drug effects , Hemodynamics/physiology , Molecular Weight , Polymers/therapeutic use
11.
Biull Eksp Biol Med ; 116(11): 552-5, 1993 Nov.
Article in Russian | MEDLINE | ID: mdl-8312561

ABSTRACT

The infusion of polyethylene oxide in anesthetised rats in a total dose of 10(-7) g/ml caused a 10-16% reduction in blood pressure. This injection has been associated with 17% decreased pressure (servo-nulling method) and 54% increased blood velocity (laser Doppler fluxmetry) in mesenteric arterioles (d - about 24 mu), but no increase in their internal diameter was observed (image-split method). Vasodilatation (adenosine, 10(-5) M) did not change the hemodynamic response of the arterioles to polymer infusion. These results suggest that microdisturbances of blood flow which can be diminished by drug-reducing polymers are more important for the vascular resistance to blood than it has been previously.


Subject(s)
Mesenteric Arteries/drug effects , Polyethylene Glycols/pharmacology , Vascular Resistance/drug effects , Animals , Arterioles/drug effects , Arterioles/physiology , Biophysical Phenomena , Biophysics , Blood Flow Velocity/drug effects , Blood Pressure/drug effects , Male , Mesenteric Arteries/physiology , Rats , Rats, Wistar
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