ABSTRACT
The study involving 48 patients with the preliminary diagnosis of acute coronary syndrome aged 54-78 years included analysis of clinical, laboratory and instrumental data for subgroups with different definitive diagnosis (myocardial infarction and unstable angina in 28 and 22 patients respectively). On the whole, the mean content of HSP-70 at admission averaged 2.1 ± 0.3 ng/ml and decreased to 1.6 ± 0.4 ng/ml (p < 0.05) after therapy. In the subgroup with myocardial infarction, the HSP-70 level (1.6 ± 0.4 ng/ml) was significantly lower than in patients with unstable angina (2.1 ± 0.3 ng/ml); p < 0.05. The reduced HSP-70 level associated with a severe myocardial lesion gives evidence against the hypothesis of these proteins as markers of myocardial dysfunction whereas a rise in their content at the onset of ischemic process suggests their protective role.
Subject(s)
Angina, Unstable , HSP70 Heat-Shock Proteins/blood , Myocardial Infarction , Myocardium , Aged , Angina, Unstable/diagnosis , Angina, Unstable/metabolism , Angina, Unstable/therapy , Biomarkers/blood , Diagnosis, Differential , Emergency Treatment , Female , Humans , Male , Middle Aged , Myocardial Infarction/diagnosis , Myocardial Infarction/metabolism , Myocardial Infarction/therapy , Myocardium/metabolism , Myocardium/pathology , Risk Factors , Statistics as TopicABSTRACT
Frequency of display endothelial dysfunction, arising on the initial stages of development arterial hypertension is investigated, depending on vascular risk factors. The main group was made by 86 men with arterial hypertension I-II stage, group of the control--practically healthy 50 men. Vasomotor endothelial function defined on a degree of vasodilatation a humeral artery in reply to reactive hyperemia. Damage signs of endothelial monolayer estimated by quantity of free circulating endothelial blue blood cells. It is established, that the simultaneous combination of functional or structural vascular infringements among persons with normal blood pressure was registered in 3 times less often in comparison to patients with an arterial hypertension (p<0,01). At the main group at a simultaneous combination inadequate vasodilatation and endotheliaemia occurrence risk factors in 1,5 times is higher, than at their isolated display (p>0,05).
