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1.
Klin Lab Diagn ; 61(1): 21-4, 2016 Jan.
Article in Russian | MEDLINE | ID: mdl-27183725

ABSTRACT

The sampling of study included 185 examined workers. Out of them 90 work at "Opitnii zavod Neftekhim" (67 females and 23 males) and 95--at "Kaustik" (64 females and 31 males) from various workshops of the given enterprises. To determine biochemical indicators samples of blood, saliva and urine were collected. The study was carried out in concordance with ethic principles of the Helsinki world medical association declaration, 2008 ed. with receiving written consent of patient to participate in study.


Subject(s)
Chemical Industry , Hydrocarbons, Aromatic/adverse effects , Occupational Diseases/diagnosis , Occupational Exposure/adverse effects , Adult , Antipyrine/administration & dosage , Antipyrine/blood , Biomarkers/blood , Biomarkers/urine , Catalase/blood , Erythrocytes/chemistry , Erythrocytes/metabolism , Female , Glutathione/blood , Glyceraldehyde-3-Phosphate Dehydrogenases/blood , Hexokinase/blood , Humans , Isoniazid/administration & dosage , Isoniazid/urine , Male , Middle Aged , Occupational Diseases/blood , Occupational Diseases/urine , Peroxidase/blood , Pyruvate Kinase/blood , Saliva/chemistry , Sodium-Potassium-Exchanging ATPase/blood , Sulfhydryl Compounds/blood , Superoxide Dismutase/blood
2.
Med Tr Prom Ekol ; (5): 7-12, 2014.
Article in Russian | MEDLINE | ID: mdl-25335420

ABSTRACT

Based on analysis of materials provided by occupational safety department PC "UZEMiK" and JSC "Kauchuk", the authors evaluate contemporary work conditions and occupational morbidity in workers engaged into rubber, mechanical rubber and tyre industries.


Subject(s)
Industry , Occupational Diseases , Occupational Health/standards , Rubber , Workplace/standards , Humans , Morbidity , Occupational Diseases/epidemiology , Occupational Diseases/etiology , Russia
3.
Klin Lab Diagn ; (12): 11-5, 2013 Dec.
Article in Russian | MEDLINE | ID: mdl-24757858

ABSTRACT

The article presents the results of studies concerning the effect of unfavorable factors of chemical nature on fluid of oral cavity among workers of the Ufa plant of elastomer materials, articles and structures. It is established that in persons contacting with chemical pollutants of manufacture of rubber and rubber technical production the indicators of chemiluminescence of saliva fluid are significantly expressed and depend on professional standing.


Subject(s)
Luminescence , Mouth/pathology , Occupational Exposure , Humans , Prognosis , Rubber/chemistry , Rubber/toxicity , Saliva/chemistry , Water Pollution, Chemical
4.
Klin Lab Diagn ; (2): 26-9, 2011 Feb.
Article in Russian | MEDLINE | ID: mdl-21506383

ABSTRACT

The paper gives the results of a study of energy metabolism in the red blood cells of the workers from OAO "Salavatnefteorgsinthez" of petrochemical industry. The energy metabolism has been found to substantially change in the examinees in contact with a mixture of organic solvents and a mixture of chlorinated solvents under industrial conditions.


Subject(s)
Environmental Pollutants/toxicity , Erythrocytes/drug effects , Hydrocarbons, Chlorinated/toxicity , Occupational Exposure/adverse effects , Solvents/toxicity , Adenine Nucleotides/blood , Adenosine Triphosphatases/blood , Chemical Industry , Energy Metabolism , Erythrocytes/metabolism , Humans , Phosphotransferases (Alcohol Group Acceptor)/blood
5.
Article in Russian | MEDLINE | ID: mdl-20967965

ABSTRACT

The article deals with the data on morbidity with temporary disability among workers producing rubber and mechanical rubber articles in petrochemical industry. The leading place in the structure of morbidity is taken by the diseases of nervous and cardiovascular systems, liver, gastrointestinal tract, respiratory system and thyroid gland.


Subject(s)
Chemical Industry , Disability Evaluation , Occupational Diseases/epidemiology , Adult , Bashkiria/epidemiology , Humans , Middle Aged , Morbidity/trends , Occupational Diseases/rehabilitation , Young Adult
6.
Klin Lab Diagn ; (7): 33-9, 2010 Jul.
Article in Russian | MEDLINE | ID: mdl-20799409

ABSTRACT

The paper gives the results of studying the processes of free radical and microsomal oxidation, antioxidant defense, and energy and electrolyte metabolism in the workers of OAO "Salavatnefteorgsintez", one of the leading petrochemical plants in the Republic of Bashkortostan. The metabolic processes have been found to substantially change in the persons contacting a mixture of chlorinated and aromatic hydrocarbons under industrial conditions.


Subject(s)
Environmental Pollutants/toxicity , Occupational Exposure/adverse effects , Air Pollutants, Occupational/toxicity , Antioxidants/analysis , Chemical Industry , Energy Metabolism , Free Radicals/analysis , Humans , Microsomes/metabolism , Oxidation-Reduction , Petroleum , Water-Electrolyte Balance
7.
Klin Lab Diagn ; (6): 22-7, 2010 Jun.
Article in Russian | MEDLINE | ID: mdl-20734861

ABSTRACT

The paper gives the results of studying the free radical oxidation-antioxidant defense (FRO-AOD) system in the blood, saliva, and urine of workers from the petrochemical industry OAO "Salavatnefteorgsintez". The FRO-AOD system has been ascertained to be considerably changed in the plasma, tear, and urine of persons contacting a mixture of petrol and Grade BP-1 solvent with organic solvents and aromatic hydrocarbons and a mixture of 1,2-dichloroethane with chlorinated hydrocarbons under industrial conditions.


Subject(s)
Air Pollutants, Occupational/toxicity , Antioxidants/metabolism , Enzymes/analysis , Free Radicals/analysis , Occupational Exposure/adverse effects , Enzymes/blood , Enzymes/urine , Female , Free Radicals/blood , Free Radicals/urine , Humans , Luminescent Measurements , Male , Occupational Diseases/chemically induced , Oxidation-Reduction , Risk Assessment , Saliva/chemistry
8.
Med Tr Prom Ekol ; (8): 11-6, 2009.
Article in Russian | MEDLINE | ID: mdl-19803355

ABSTRACT

The article covers results of studies concerning adenylic system state in RBC and tissues (lungs; liver, kidneys, heart, brain) of rats exposed to acute and chronic inhalation of chemical pollutants widely used in petrochemical and oil-processing industries. Findings are that the animals subjected to ecologic toxic agents have significantly decreased ATP level, ADP and AMF accumulation in tissues and RBC.


Subject(s)
Adenine Nucleotides/metabolism , Air Pollutants/adverse effects , Hydrocarbons, Aromatic/adverse effects , Hydrocarbons, Chlorinated/adverse effects , Solvents/adverse effects , Adenosine Diphosphate/metabolism , Adenosine Monophosphate/metabolism , Adenosine Triphosphate/metabolism , Animals , Brain/drug effects , Brain/metabolism , Extraction and Processing Industry , Heart/drug effects , Kidney/drug effects , Kidney/metabolism , Liver/drug effects , Liver/metabolism , Lung/drug effects , Lung/metabolism , Myocardium/metabolism , Rats
9.
Klin Lab Diagn ; (2): 21-2, 35-6, 2009 Feb.
Article in Russian | MEDLINE | ID: mdl-19338088

ABSTRACT

The paper presents data on the antioxidative activity of blood, saliva, tear, and urine in petrochemical industry workers. The chemiluminescence values of plasma, saliva, tear, and urine were ascertained to be significantly higher in the persons contacting chemical pollutants.


Subject(s)
Antioxidants/metabolism , Blood/metabolism , Luminescent Measurements/methods , Occupational Exposure/adverse effects , Saliva/metabolism , Urine , Adult , Blood Chemical Analysis/methods , Female , Humans , Male , Middle Aged
10.
Klin Lab Diagn ; (1): 9-13, 2009 Jan.
Article in Russian | MEDLINE | ID: mdl-19253692

ABSTRACT

The paper presents the results of studies of free radical oxidation (FRO) and antioxidant defense (AOD) in the blood, oral fluid, and urine of petrochemical industrial workers. The red blood cell, plasma, oral fluid, and urine values of FRO and AOD has been ascertained to be much pronounced in persons contacting chemical pollutants during production.


Subject(s)
Antioxidants/metabolism , Free Radicals/blood , Free Radicals/urine , Occupational Exposure/adverse effects , Solvents/adverse effects , Chemical Industry , Female , Humans , Male , Oxidation-Reduction
11.
Med Tr Prom Ekol ; (9): 41-4, 2008.
Article in Russian | MEDLINE | ID: mdl-19062586

ABSTRACT

The authors present results obtained in a study of how rubber and technical rubber products influence acid and osmotic resistance of RBC in workers engaged into petrochemical industry. Findings are that the rubber and technical rubber products sensitize the RBC to osmotic and acidic lysis.


Subject(s)
Acids , Chemical Industry/statistics & numerical data , Erythrocytes/physiology , Occupational Diseases/blood , Occupational Diseases/epidemiology , Petroleum , Rubber , Humans , Occupational Diseases/diagnosis , Osmotic Pressure , Time Factors
12.
Med Tr Prom Ekol ; (12): 10-5, 2008.
Article in Russian | MEDLINE | ID: mdl-19227872

ABSTRACT

The article covers evaluation of health state in workers of main petrochemical workshops. Leading place in structure of transitory disablement morbidity in workers is occupied by cardiovascular and nervous disorders, diseases of liver, gastrointestinal tract and respiratory system.


Subject(s)
Chemical Industry , Health Status , Occupational Diseases/epidemiology , Occupational Health , Adult , Disability Evaluation , Female , Humans , Male , Middle Aged , Morbidity/trends , Risk Factors , Russia/epidemiology , Young Adult
13.
Med Tr Prom Ekol ; (8): 14-9, 2007.
Article in Russian | MEDLINE | ID: mdl-17924488

ABSTRACT

The article deals with results of studies covering free radical oxidation and peroxidation in RBC, serum, saliva and urine of petrochemistry workers. Individuals exposed to chemical pollutants in production of rubber, tyre and mechanical rubber goods appeared to have considerably increased free radical oxidation parameters in RBC, serum, saliva and urine.


Subject(s)
Chemical Industry , Free Radical Scavengers/metabolism , Lipid Peroxidation/physiology , Occupational Diseases/metabolism , Occupational Exposure/adverse effects , Adult , Erythrocytes/metabolism , Female , Humans , Male , Malondialdehyde/metabolism , Middle Aged , Occupational Diseases/etiology , Risk Factors , Saliva/metabolism , Spectrophotometry , Urine/chemistry
14.
Klin Lab Diagn ; (7): 21-3, 2003 Jul.
Article in Russian | MEDLINE | ID: mdl-12934328

ABSTRACT

Data on the impact exerted by industrial products, i.e. pyromellitic dianhydride, on the acidic and osmotic resistance of erythrocytes in workers are described. The influence of hazardous factors of the oil-and-chemical production was found to result in a changing erythrocytes' resistance (of workers) to the osmotic and acidic hemolytics with regard for a labor record and duration of contact with toxicants. The shifts in acidic and osmotic resistance can serve as an early marker of changes in the functional erythron's status in workers occupied under hazardous industrial factors.


Subject(s)
Air Pollutants, Occupational/adverse effects , Erythrocytes/drug effects , Hydrochloric Acid/adverse effects , Adult , Female , Hemolysis , Humans , Male , Middle Aged , Osmotic Pressure , Petroleum
15.
Patol Fiziol Eksp Ter ; (1): 26-8, 2003.
Article in Russian | MEDLINE | ID: mdl-12652942

ABSTRACT

The paper presents the results of studies of the amounts of diene conjugates, malonic dialdehyde, and Schiff's bases, which are molecular LPO products in the tissues of the lung, liver, kidney in animals exposed to 4-hour inhalation of cyclic hydrocarbons (pyromellitic dianhydride, durol, pseudocumene, and dioxane-1,4). Exposure to ecotoxicants at concentrations of 10 and 1 mg/m3 was found to result in the accumulation of initial, intermediate, and final molecular LPO products. These changes were recorded only after exposure to pseudocumene and dioxane vapors in a dose of 0.1 mg/m3 and after inhalation of dioxane-1,4 vapors in a dose of 0.01 mg/m3.


Subject(s)
Hydrocarbons, Cyclic/toxicity , Lipid Peroxidation/drug effects , Administration, Inhalation , Air Pollutants/toxicity , Animals , Benzene Derivatives/toxicity , Benzoates/administration & dosage , Benzoates/toxicity , Dioxanes/toxicity , Hydrocarbons, Cyclic/administration & dosage , Kidney/drug effects , Kidney/metabolism , Liver/drug effects , Liver/metabolism , Lung/drug effects , Lung/metabolism , Malondialdehyde/metabolism , Rats , Schiff Bases/metabolism , Xenobiotics/pharmacology
16.
Patol Fiziol Eksp Ter ; (4): 13-6, 2002.
Article in Russian | MEDLINE | ID: mdl-12638423

ABSTRACT

The authors' investigations show that red cells and tissues of animals exposed to a single 4-h inhalation of vapors of 1,2,4-trimethylbenzene in concentration 10 mg/m3 contained reduced amount of ATP, accumulated amounts of ADP, AMP in active inclusion of 32-P in the structure of these compounds. Activation of ATPase is accompanied with a rise of Na and P concentrations and fall in K, Mg and Ca ions concentrations. In blood plasm there were lower levels of Na and Ca and higher levels of K, Mg and P ions. In exposure to ecotoxicant in concentration 0.01-0.1 and 1.0 mg/m3 the changes were insignificant.


Subject(s)
Adenine Nucleotides/metabolism , Benzene Derivatives/toxicity , Energy Metabolism/drug effects , Environmental Pollutants/toxicity , Adenine Nucleotides/blood , Adenosine Diphosphate/blood , Adenosine Diphosphate/metabolism , Adenosine Monophosphate/blood , Adenosine Monophosphate/metabolism , Adenosine Triphosphate/blood , Adenosine Triphosphate/metabolism , Administration, Inhalation , Animals , Erythrocytes/metabolism , Kidney/metabolism , Liver/metabolism , Lung/metabolism , Rats
17.
Gig Sanit ; (4): 53-6, 2001.
Article in Russian | MEDLINE | ID: mdl-11530642

ABSTRACT

This paper gives data on the levels of cytochromes of B5, P450, P420, P450 + P420, on the rates of amidopyrinum N-demethylation and aniline n-hydroxylation in the tissues of the lung, liver, kidney of experimental rats upon acute and chronic (4-month) inhalation exposure to pseudocumol and durol at a concentration of 10 mg/m3. Acute and chronic inhalation exposures to the xenobiotics in this concentration result in activation of microsomal monooxygenases in the tissues of experimental rats in relation to the type of exposure.


Subject(s)
Benzene Derivatives/toxicity , Inhalation Exposure , Microsomes/drug effects , Animals , Cytochromes/metabolism , Hydroxylation , Kidney/drug effects , Kidney/metabolism , Liver/drug effects , Liver/metabolism , Lung/drug effects , Lung/metabolism , Methylation , Microsomes/enzymology , Microsomes, Liver/drug effects , Microsomes, Liver/enzymology , Rats , Time Factors , Xenobiotics/metabolism
18.
Klin Lab Diagn ; (5): 41-4, 2001.
Article in Russian | MEDLINE | ID: mdl-11507886

ABSTRACT

Disorders in erythrocyte energy metabolism, plasma and erythrocyte electrolyte metabolism, erythrocyte, plasma, and urinary free-radical oxidation, and in the urinary microsomal monoxigenase system were detected in workers engaged in oil-processing industry. All examinees were divided into 3 groups with different intensity of exposure to chemical pollutants: 1) workers having no contacts with chemicals (n = 21); 2) workers exposed to chemicals 2-3 times a week (n = 28, risk group); and 3) workers permanently exposed to chemicals for 3-5 years (n = 45). Control group consisted of 40 subjects occupationally not exposed to chemicals. The findings indicate marked changes in energy metabolism, free-radical and microsomal oxidation, and electrolyte metabolism in group 2 and more so in group 3.


Subject(s)
Air Pollutants, Occupational/adverse effects , Electrolytes/blood , Energy Metabolism , Extraction and Processing Industry , Microsomes/metabolism , Data Interpretation, Statistical , Female , Free Radicals , Humans , Lipid Peroxidation , Male , Microsomes/enzymology , Oxidation-Reduction , Time Factors
19.
Gig Sanit ; (3): 49-52, 2001.
Article in Russian | MEDLINE | ID: mdl-11519463

ABSTRACT

The influence of unfavourable factors of the industrial environment on electrolyte balance in the red blood cells and plasma of workers engaged in petroleum-refining industry was studied. All examinees were divided into 3 groups in terms of the exposure to chemical pollutants: 1) workers unexposed to chemical pollutants; 2) those exposed to them 2-3 times a week; 3) those exposed constantly during their work for 3-5 years. A control group included individuals who were not engaged in chemical industry. Groups 2 and 3 showed decreases in the levels of K, Mg, and Ca and increases in the concentrations of Na and P in the red blood cells and in those of K, Mg, and P in the plasma while plasma Na and Ca reduced.


Subject(s)
Air Pollutants, Occupational/adverse effects , Electrolytes/blood , Extraction and Processing Industry , Petroleum , Adult , Calcium/blood , Female , Humans , Magnesium/blood , Male , Middle Aged , Potassium/blood , Sodium/blood , Time Factors
20.
Klin Lab Diagn ; (6): 14-6, 2001 Jun.
Article in Russian | MEDLINE | ID: mdl-11521590

ABSTRACT

Free radical lipid peroxidation in erythrocytes, plasma, and urine was studied in workers engaged in oil processing industry. The examinees were divided into 3 groups with different intensity of exposure to chemical factors: 1) 21 workers without contacts with chemicals; 2) 28 workers handling chemicals 2-3 times a weeks (risk group); 3) 46 workers permanently exposed to chemicals for 3-5 years. Control group consisted of 40 workers occupationally not exposed to chemicals. Free radical lipid peroxidation in erythrocytes, plasma, and urine was intensified in groups 2 and more so in group 3.


Subject(s)
Air Pollutants, Occupational , Extraction and Processing Industry , Lipid Peroxidation , Occupational Exposure , Petroleum , Adult , Female , Free Radicals , Humans , Male , Middle Aged
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