ABSTRACT
The significance of neurospecific proteins in the diagnosis of neurotoxicity in patients with breast, lung, testicular, and ovarian cancer treated by taxane and cisplatin drugs was evaluated. The most pronounced increase in the content of these proteins and titers of autoantibodies to these proteins was observed in patients with clinical manifestations of neurotoxicity induced by cytostatics. A strong correlation was found between the concentration of myelin basic protein and cumulative dose of the drug (R=0.922; p<0.0001). These data suggest that myelin basic protein and gliofibrillar acid protein can be used as markers in the diagnosis and monitoring of antitumor drug neurotoxicity.
Subject(s)
Antineoplastic Agents/pharmacology , Neurons/drug effects , Autoantibodies/biosynthesis , Breast Neoplasms/drug therapy , Cisplatin/pharmacology , Dose-Response Relationship, Drug , Female , Glial Fibrillary Acidic Protein/blood , Humans , Lung Neoplasms/drug therapy , Male , Myelin Basic Protein/blood , Neurons/metabolism , Ovarian Neoplasms/drug therapy , Testicular Neoplasms/drug therapy , Time FactorsSubject(s)
Paraneoplastic Syndromes/diagnosis , Humans , Paraneoplastic Cerebellar Degeneration/classification , Paraneoplastic Cerebellar Degeneration/diagnosis , Paraneoplastic Polyneuropathy/classification , Paraneoplastic Polyneuropathy/diagnosis , Paraneoplastic Syndromes/classification , Spinal Cord Diseases/classification , Spinal Cord Diseases/diagnosisSubject(s)
Brain Injuries/complications , Brain/radiation effects , Encephalomyelitis/etiology , Leukoencephalitis, Acute Hemorrhagic/etiology , Leukoencephalopathy, Progressive Multifocal/etiology , Radiation Injuries/complications , Spinal Cord Injuries/etiology , Brain/pathology , Humans , Radiation Dosage , Radiation, Ionizing , Spinal Cord Injuries/pathologyABSTRACT
A study was made of a possibility to use immunological methods (the leucocyte migration inhibition test, leukergia reaction, the test of the cold fixation of the complement with cerebral antigen) for the assessment of neurotoxic and neuroradiation effects in total therapeutic irradiation of man at a dose of 10 Gy with preceding polychemotherapy. A rapid development of agranulocytosis made cellular reactions impossible. The above effects could be assessed using humoral specific immunological reactions. A possible role of anticerebral antibodies in the pathogenesis of neurological disorders was discussed.
