ABSTRACT
Angiogenic T/natural killer (NK)-cell lymphoma is a non-Hodgkin lymphoma characterized by necrosis and vascular destruction that is strongly associated with Epstein-Barr virus and AIDS. Early diagnosis is essential to improve the chances of patient survival, but severe local inflammatory infiltrate impairs histologic diagnosis by obscuring neoplastic cells. The most common markers are CD2, CD56, cytoplasmic CD3, and CD43 EBV. We describe 3 cases of angiogenic T/NK-cell lymphoma that show the diverse presentation of the same disease. Patient 1 was HIV positive and had nasal obstruction, facial edema, and ulceration of the nasal mucosa. Patient 2 had fever, a sore throat, and weight loss. Patient 3 had facial edema, fever, proptosis, and rapid development of neurologic alterations. Several biopsies were needed for histologic confirmation in these patients, despite positivity for the CD3 and CD56 markers.
Subject(s)
Lymphoma, Non-Hodgkin/pathology , CD3 Complex/analysis , CD56 Antigen/analysis , Humans , Killer Cells, Natural/pathology , Lymphoma, T-Cell/pathologyABSTRACT
O siringoma condróide maligno, também designado tumor misto maligno da pele, é lesão extremamente rara com aproximadamente 40 casos descritos até o presente momento. Trata-se de neoplasia derivada das glândulas sudoríparas que acomete preferencialmente tronco e extremidades distais em pacientes na sexta década e predomina no sexo feminino. Relatamos um caso com os aspectos clínicos e histológicos característicos para familiarizar o patologista com esse diagnóstico, visto que essa neoplasia com freqüência apresenta metástases locais e/ou regionais (cerca de 60 por cento), sobretudo para linfonodos, pulmões e ossos; além disso, possui taxa de mortalidade de aproximadamente 25 por cento após curso evolutivo prolongado.
Malignant chondroid syringoma (malignant mixed tumor of the skin) is an extremely rare tumor. Approximately 40 cases have been described to date. It is a neoplasm originated from sweat gland. The tumor predominantly affects the trunk and distal extremities, arises in the sixth decade and shows a predilection for females. We relate one case with clinical and histopathologic typical features to alert the pathologist to this diagnosis, since this neoplasm has a metastasic rate of approximately 60 percent (lymph nodes, lungs and bones are predominantly affected) and a mortality of roughly 25 percent.
Subject(s)
Humans , Male , Middle Aged , Adenoma, Pleomorphic/diagnosis , Adenoma, Pleomorphic/pathology , Rare Diseases/diagnosis , Sweat Gland Neoplasms/pathology , ImmunohistochemistryABSTRACT
The embryologic origin of the breast is related to salivary and sweats glands. Thus, breast neoplasms may show differentiation toward these tissues, although this is a rare event in humans. We report the clinicopathologic and immunohistochemical features of a 57-year-old woman presenting with a spiradenoma that originated in breast tissue and became malignant 40 years later. Some histogenetic concepts relevant to this case are discussed, along with a brief review of this neoplasm.
Subject(s)
Adenoma, Sweat Gland/pathology , Breast Neoplasms/pathology , Carcinoma, Skin Appendage/pathology , Neoplasms, Second Primary/pathology , Sweat Gland Neoplasms/pathology , Adenoma, Sweat Gland/metabolism , Adenoma, Sweat Gland/surgery , Biomarkers, Tumor/metabolism , Breast Neoplasms/metabolism , Breast Neoplasms/surgery , Carcinoma, Skin Appendage/metabolism , Carcinoma, Skin Appendage/surgery , Female , Humans , Immunohistochemistry , Keratins/metabolism , Mastectomy , Middle Aged , Mucin-1/metabolism , Neoplasms, Second Primary/metabolism , Neoplasms, Second Primary/surgery , Sweat Gland Neoplasms/metabolism , Sweat Gland Neoplasms/surgeryABSTRACT
Herpes gestationis é dermatose relacionada à gravidez, rara, caracterizando-se pela erupçäo de vesículas e bolhas sobre a base eritematosa, no tronco e membros, mais freqüente no segundo e terceiro trimestres da gestaçäo. No presente caso, os quadros clínicos e laboratorial säo sugestivos
Subject(s)
Humans , Female , Pregnancy , Adult , Pemphigoid Gestationis/diagnosis , Pemphigoid Gestationis/drug therapy , Prednisone/therapeutic use , Pregnancy Complications , Pruritus/etiology , Contraceptives, Oral , Diagnosis, Differential , Recurrence , Skin Diseases/diagnosisABSTRACT
Apresenta-se o caso de um paciente de 26 anos, assintomática, que ao realizar uma abreugrafia rotineira apresentou lesöes radiológicas nodulares. O diagnóstico histopatológico obtido por biopsia pulmonar foi o de granuloma eosinófilo confinado ao pulmäo, uma vez que extensiva pesquisa de comprometimento de outros órgäos, especialmente ossos, foram negativas. Ressalta-se a dificuldade do diagnóstico e faz-se revisäo da literatura. Estuda-se a evoluçäo clínica da paciente submetida a terapêutica com corticosteróides, após três anos de seguimento
