[Treatment of patients with B-small cell lymphoma using R-CHOP protocol]. / Opyt lecheniia bol'nykh B-kletochnoi limfomoi po skheme R-CHOP.

Non-Hodgkin's lymphoma is one of the most challenging problems in modern oncology. Creation of drugs inhibiting specifically intracellular signal tracks which being activated in its turn lead to oncogenes hyperexpression and inactivating other genes responsible for suppression of oncogenes, leading eventually to a cell's constant proliferation. This method is a new approach for cancer treatment. Nowadays homogeneous antibodies are widely used against superficial lymphocyte antigens. Rituximab is an anti-CD20 antibody fixed on the surface of malignant cells of most B-small cell lymphomas. In the department of systematic tumors at the institute of oncology of Medical Academy of Sciences a patient with large diffuse B-cell lymphomas had received Rituximab treatment. After the treatment, laboratory data and clinical investigation of the patient showed no signs of the disease. The patient was under observation at the institute of oncology of Medical Academy of Sciences over one year and found clinically, and according to its laboratory data, in a stable remission state.

[The efficacy of using low doses of immunomodulators for treating experimental tumors]. / Effektivnost' primeneniia malykh doz immunomoduliatorov dlia lecheniia éksperimental'nykh opukholei.

The data about the ability of various substances to cause definite reactions in biological objects are adduced, and, in particular, about the efficacy of a small doses of antitumoral chemopreparations in experiment. The results of investigation of the application efficacy of various doses of immunomodulating agents, such as arbisol, nucleoplat, the substrate from gram-negative bacteria Yersinia enterocolitica, antitumoral vaccine from the tumoral cells are presented for the cancer chemotherapy. While application of super-small doses of an antitumoral vaccine there was noted statistically significant inhibition of tumoral growth.

[Results and the prospects of use of the new chemical preparation polyplatillene with antineoplastic and antiviral properties]. / Rezul'taty i perspektivy primeneniia novogo khimiopreparata poliplatillena, obladaiushchego protivoopukholevymi i protivovirusnymi svoístvami.

Ten years experience of the polyplatillene clinical application and experimental study is summarized. Results of treatment of 689 inner organs cancer patients stage IV, I-IV clinical groups. The advantages of polyplatillene versus others platinum group chemopreparations are shown. Manufacturing difficulties, mistakes and perils of the preparation application are pointed out. The direct dose-dependence of results is shown. Possibilities of polyplatillene application in biotechnology, radiology, virusology as a regulator of the cell division, viral replication and their interaction with a cell is shown.

[Antiviral action of the macromolecular derivative of the platinum with deoxyribonucleic acid in the treatment of patient with malignant liver neoplasm]. / Protivovirusnoe deistvie makromolekuliarnogo proizvodnogo platiny s dezoksiribonukleinovoi kislotoi u bolnykh so zlokachestvennoi opukholíu pecheni.

Results of the action of a preparation consisting of cis-dichlorodiammineplatinum and deoxyribonucleic acid combined in the saline balanced solution by means of the original technique on cytomegalovirus infection of patients with cancer of the liver are presented. Clearly pronounced antivirus activity of the preparation developed is noted.

[Rationale for surgical treatment of focal liver diseases]. / Vybor ratsionalnogo sposoba khirurgicheskogo vmeshatelstva pri ochagovom porazhenii pecheni.

A 19-year experience with surgical treatment of the patients with focal hepatic lesions is presented. Hepatic resection was performed in 149 patients. Of them, 52 underwent atypical resection with the use of ultrasound aspirator, laser scalpel, temporary exclusion of the liver out of circulation, placement of staple suture of the parenchyma, preliminary roentgenovascular embolization of the major vessels of the lobe removed. A modern classification of the methods of hepatic resection reflecting most accurately a volume of the parenchyma removed is presented. The postoperative lethality was 6.08%.

[The differential diagnosis and therapeutic procedure in nontumorous mechanical jaundice and cholangitis]. / Differentsial'naia diagnostika i lechebnaia taktika pri neopukholevoi mekhanicheskoi zheltukhe i kholangite.

The results of operative treatment of 2,875 patients with obstructive jaundice and cholangitis of nonneoplastic genesis are generalized. On the basis of rich clinical experience, the authors substantiate the principles of differential and topical diagnosis in obstructive jaundice and purulent cholangitis as well as the optimal therapeutic tactics in obstruction of the bile ducts of various levels and types. Problems are elaborated with respect of complex antibacterial therapy with the use of various routes of administration, including administration in the pre- and intraoperative period for preventive purposes.

[Preclinical trials of polyplatillen, the antitumor activity of a complex platinum compound with DNA on a leukemia P388 model in a HEp-2 cell culture (1)]. / Doklinicheskie ispytaniia poliplatillena, protivoopukholevaia aktivnost' kompleksnogo soedineniia platiny s DNK na modeli leikemii P-388 v kul'ture kletok HEp-2 (soobshchenie 1).

The authors studied the antitumour activity of a new complex platinum compound (DDP-DNA) in mice with leukemia P-388 and in cell culture. DDP-DNA was introduced intraperitoneally 24 hours after inoculation of 2 x 10(6) tumour cells. It was established that by its antitumour activity DDP-DNA was not inferior then DDP. The antiproliferative activity of nontoxic doses of the preparation in cell culture has been shown.

[Endovascular regional infusion therapy in the combined treatment of liver abscess]. / Endovaskuliarnaia regionarnaia infuzionnaia terapiia v kompleksnom lechenii abstsessa pecheni.

The comparative assessment of the effectiveness of endovascular regional infusion therapy (ERIT) in the complex of treatment of a hepatic abscess in 16 patients was carried out. In 12 patients, it was performed in combination with surgical intervention, in 4--as an independent method of treatment. In patients with a solitary hepatic abscess, it is expedient to include ERIT into the complex of therapeutic measures in combination with abscess puncture under ultrasound guidance. In presence of multiple abscesses of the liver, ERIT is a method of choice.