Listener effort quantifies clinically meaningful progression of dysarthria in people living with amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative motor neuron disease that causes progressive muscle weakness. Progressive bulbar dysfunction causes dysarthria and thus social isolation, reducing quality of life. The Everything ALS Speech Study obtained longitudinal clinical information and speech recordings from 292 participants. In a subset of 120 participants, we measured speaking rate (SR) and listener effort (LE), a measure of dysarthria severity rated by speech pathologists from recordings. LE intra- and inter-rater reliability was very high (ICC 0.88 to 0.92). LE correlated with other measures of dysarthria at baseline. LE changed over time in participants with ALS (slope 0.77 pts/month; p<0.001) but not controls (slope 0.005 pts/month; p=0.807). The slope of LE progression was similar in all participants with ALS who had bulbar dysfunction at baseline, regardless of ALS site of onset. LE could be a remotely collected clinically meaningful clinical outcome assessment for ALS clinical trials.

The Long and Winding Road to Real-Life Experiments: Remote Assessment of Executive Functions with Computerized Games-Results from 8 Years of Naturalistic Interventions.

Mate Marote is an open-access cognitive training software aimed at children between 4 and 8 years old. It consists of a set of computerized games specifically tailored to train and evaluate Executive Functions (EF), a class of processes critical for purposeful, goal-directed behavior, including working memory, planning, flexibility, and inhibitory control. Since 2008, several studies were performed with this software at children's own schools in interventions supervised in-person by cognitive scientists. After 2015, we incorporated naturalistic, yet controlled, interventions with children's own teachers' help. The platform includes a battery of standardized tests, disguised as games, to assess children's EF. The main question that emerges is whether the results, obtained with these traditional tasks but conducted without the presence of researchers, are comparable to those widely reported in the literature, that were obtained in more supervised settings. In this study, we were able to replicate the expected difficulty and age effects in at least one of the analyzed dependent variables of each employed test. We also report important discrepancies between the expected and the observed response time patterns, specifically for time-constrained tasks. We hereby discuss the benefits and setbacks of a new possible strategy for this type of assessment in naturalistic settings. We conclude that this battery of established EF tasks adapted for its remote usage is appropriate to measure the expected mental processes in naturalistic settings, enriching opportunities to upscale cognitive training interventions at schools. These types of tools can constitute a concerted strategy to bring together educational neuroscience research and real-life practice.

Assessing robustness and generalization of a deep neural network for brain MS lesion segmentation on real-world data.

OBJECTIVES: Evaluate the performance of a deep learning (DL)-based model for multiple sclerosis (MS) lesion segmentation and compare it to other DL and non-DL algorithms. METHODS: This ambispective, multicenter study assessed the performance of a DL-based model for MS lesion segmentation and compared it to alternative DL- and non-DL-based methods. Models were tested on internal (n = 20) and external (n = 18) datasets from Latin America, and on an external dataset from Europe (n = 49). We also examined robustness by rescanning six patients (n = 6) from our MS clinical cohort. Moreover, we studied inter-human annotator agreement and discussed our findings in light of these results. Performance and robustness were assessed using intraclass correlation coefficient (ICC), Dice coefficient (DC), and coefficient of variation (CV). RESULTS: Inter-human ICC ranged from 0.89 to 0.95, while spatial agreement among annotators showed a median DC of 0.63. Using expert manual segmentations as ground truth, our DL model achieved a median DC of 0.73 on the internal, 0.66 on the external, and 0.70 on the challenge datasets. The performance of our DL model exceeded that of the alternative algorithms on all datasets. In the robustness experiment, our DL model also achieved higher DC (ranging from 0.82 to 0.90) and lower CV (ranging from 0.7 to 7.9%) when compared to the alternative methods. CONCLUSION: Our DL-based model outperformed alternative methods for brain MS lesion segmentation. The model also proved to generalize well on unseen data and has a robust performance and low processing times both on real-world and challenge-based data. CLINICAL RELEVANCE STATEMENT: Our DL-based model demonstrated superior performance in accurately segmenting brain MS lesions compared to alternative methods, indicating its potential for clinical application with improved accuracy, robustness, and efficiency. KEY POINTS: • Automated lesion load quantification in MS patients is valuable; however, more accurate methods are still necessary. • A novel deep learning model outperformed alternative MS lesion segmentation methods on multisite datasets. • Deep learning models are particularly suitable for MS lesion segmentation in clinical scenarios.

Neural Bases of Predictions During Natural Reading of Known Statements: An Electroencephalography and Eye Movements Co-registration Study.

Predictions of incoming words performed during reading have an impact on how the reader moves their eyes and on the electrical brain potentials. Eye tracking (ET) experiments show that less predictable words are fixated for longer periods of times. Electroencephalography (EEG) experiments show that these words elicit a more negative potential around 400 ms (N400) after the word onset when reading one word at a time (foveated reading). Nevertheless, there was no N400 potential during the foveated reading of previously known sentences (memory-encoded), which suggests that the prediction of words from memory-encoded sentences is based on different mechanisms than predictions performed on common sentences. Here, we performed an ET-EEG co-registration experiment where participants read common and memory-encoded sentences. Our results show that the N400 potential disappear when the reader recognises the sentence. Furthermore, time-frequency analyses show a larger alpha lateralisation and a beta power increase for memory-encoded sentences. This suggests a more distributed attention and an active maintenance of the cognitive set, in concordance to the predictive coding framework.

Expanding horizons of cross-linguistic research on reading: The Multilingual Eye-movement Corpus (MECO).

Scientific studies of language behavior need to grapple with a large diversity of languages in the world and, for reading, a further variability in writing systems. Yet, the ability to form meaningful theories of reading is contingent on the availability of cross-linguistic behavioral data. This paper offers new insights into aspects of reading behavior that are shared and those that vary systematically across languages through an investigation of eye-tracking data from 13 languages recorded during text reading. We begin with reporting a bibliometric analysis of eye-tracking studies showing that the current empirical base is insufficient for cross-linguistic comparisons. We respond to this empirical lacuna by presenting the Multilingual Eye-Movement Corpus (MECO), the product of an international multi-lab collaboration. We examine which behavioral indices differentiate between reading in written languages, and which measures are stable across languages. One of the findings is that readers of different languages vary considerably in their skipping rate (i.e., the likelihood of not fixating on a word even once) and that this variability is explained by cross-linguistic differences in word length distributions. In contrast, if readers do not skip a word, they tend to spend a similar average time viewing it. We outline the implications of these findings for theories of reading. We also describe prospective uses of the publicly available MECO data, and its further development plans.

Information Structure and Word Order Canonicity in the Comprehension of Spanish Texts: An Eye-Tracking Study.

Word order alternation has been described as one of the most productive information structure markers and discourse organizers across languages. Psycholinguistic evidence has shown that word order is a crucial cue for argument interpretation. Previous studies about Spanish sentence comprehension have shown greater difficulty to parse sentences that present a word order that does not respect the order of participants of the verb's lexico-semantic structure, irrespective to whether the sentences follow the canonical word order of the language or not. This difficulty has been accounted as the cognitive cost related to the miscomputation of prominence status of the argument that precedes the verb. Nonetheless, the authors only analyzed the use of alternative word orders in isolated sentences, leaving aside the pragmatic motivation of word order alternation. By means of an eye-tracking task, the current study provides further evidence about the role of information structure for the comprehension of sentences with alternative word order and verb type, and sheds light on the interaction between syntax, semantics and pragmatics. We analyzed both "early" and "late" eye-movement measures as well as accuracy and response times to comprehension questions. Results showed an overall influence of information structure reflected in a modulation of late eye-movement measures as well as offline measures like total reading time and questions response time. However, effects related to the miscomputation of prominence status did not fade away when sentences were preceded by a context that led to non-canonical word order of constituents, showing that prominence computation is a core mechanism for argument interpretation, even in sentences preceded by context.

Corrigendum: Risks for Child Cognitive Development in Rural Contexts.

[This corrects the article DOI: 10.3389/fpsyg.2018.02735.].

Brain folding shapes the branching pattern of the middle cerebral artery.

The folds of the brain offer a particular challenge for the subarachnoid vascular grid. The primitive blood vessels that occupy this space, when the brain is flat, have to adapt to an everchanging geometry while constructing an efficient network. Surprisingly, the result is a non-redundant arterial system easily challenged by acute occlusions. Here, we generalize the optimal network building principles of a flat surface growing into a folded configuration and generate an ideal middle cerebral artery (MCA) configuration that can be directly compared with the normal brain anatomy. We then describe how the Sylvian fissure (the fold in which the MCA is buried) is formed during development and use our findings to account for the differences between the ideal and the actual shaping pattern of the MCA. Our results reveal that folding dynamics condition the development of arterial anastomosis yielding a network without loops and poor response to acute occlusions.

Motor representations underlie the reading of unfamiliar letter combinations.

Silent reading is a cognitive operation that produces verbal content with no vocal output. One relevant question is the extent to which this verbal content is processed as overt speech in the brain. To address this, we acquired sound, eye trajectories and lips' dynamics during the reading of consonant-consonant-vowel (CCV) combinations which are infrequent in the language. We found that the duration of the first fixations on the CCVs during silent reading correlate with the duration of the transitions between consonants when the CCVs are actually uttered. With the aid of an articulatory model of the vocal system, we show that transitions measure the articulatory effort required to produce the CCVs. This means that first fixations during silent reading are lengthened when the CCVs require a greater laryngeal and/or articulatory effort to be pronounced. Our results support that a speech motor code is used for the recognition of infrequent text strings during silent reading.

Human and computer estimations of Predictability of words in written language.

When we read printed text, we are continuously predicting upcoming words to integrate information and guide future eye movements. Thus, the Predictability of a given word has become one of the most important variables when explaining human behaviour and information processing during reading. In parallel, the Natural Language Processing (NLP) field evolved by developing a wide variety of applications. Here, we show that using different word embeddings techniques (like Latent Semantic Analysis, Word2Vec, and FastText) and N-gram-based language models we were able to estimate how humans predict words (cloze-task Predictability) and how to better understand eye movements in long Spanish texts. Both types of models partially captured aspects of predictability. On the one hand, our N-gram model performed well when added as a replacement for the cloze-task Predictability of the fixated word. On the other hand, word embeddings were useful to mimic Predictability of the following word. Our study joins efforts from neurolinguistic and NLP fields to understand human information processing during reading to potentially improve NLP algorithms.

Fading of collective attention shapes the evolution of linguistic variants.

Language change involves the competition between alternative linguistic forms. The spontaneous evolution of these forms typically results in monotonic growths or decays, such as in winner-take-all attractor behaviors. In the case of the Spanish past subjunctive, the spontaneous evolution of its two competing forms (ending in -ra and -se) was perturbed by the appearance of the Royal Spanish Academy in 1713, which enforced the spelling of both forms as perfectly interchangeable variants, at a moment in which the -ra form was predominant. Time series extracted from a massive corpus of books reveal that this regulation in fact produced a transient renewed interest for the old form -se which, once faded, left the -ra again as the dominant form up to the present day. We show that time series are successfully explained by a two-dimensional linear model that integrates an imitative and a novelty component. The model reveals that the temporal scale over which collective attention fades is in inverse proportion to the verb frequency. The integration of the two basic mechanisms of imitation and attention to novelty allows us to understand diverse competing objects, with lifetimes that range from hours for memes and news to decades for verbs, suggesting the existence of a general mechanism underlying cultural evolution.

Predicting Known Sentences: Neural Basis of Proverb Reading Using Non-parametric Statistical Testing and Mixed-Effects Models.

Predictions of future events play an important role in daily activities, such as visual search, listening, or reading. They allow us to plan future actions and to anticipate their outcomes. Reading, a natural, commonly studied behavior, could shed light over the brain processes that underlie those prediction mechanisms. We hypothesized that different mechanisms must lead predictions along common sentences and proverbs. The former ones are more based on semantic and syntactic cues, and the last ones are almost purely based on long-term memory. Here we show that the modulation of the N400 by Cloze-Task Predictability is strongly present in common sentences, but not in proverbs. Moreover, we present a novel combination of linear mixed models to account for multiple variables, and a cluster-based permutation procedure to control for multiple comparisons. Our results suggest that different prediction mechanisms are present during reading.

Language, gesture, and judgment: Children's paths to abstract geometry.

As infants, children are sensitive to geometry when recognizing objects or navigating through rooms; however, explicit knowledge of geometry develops slowly and may be unstable even in adults. How can geometric concepts be both so accessible and so elusive? To examine how implicit and explicit geometric concepts develop, the current study assessed, in 132 children (3-8 years old) while they played a simple geometric judgment task, three distinctive channels: children's choices during the game as well as the language and gestures they used to justify and accompany their choices. Results showed that, for certain geometric properties, children chose the correct card even if they could not express with words (or gestures) why they had made this choice. Furthermore, other geometric concepts were expressed and supported by gestures prior to their articulation in either choices or speech. These findings reveal that gestures and behavioral choices may reflect implicit knowledge and serve as a foundation for the development of geometric reasoning. Altogether, our results suggest that language alone might not be enough for expressing and organizing geometric concepts and that children pursue multiple paths to overcome its limitations, a finding with potential implications for primary education in mathematics.

Patrones de correlación de fluencias semánticas y fonológicas en niños en edad escolar / Correlational Patterns in Semantic and Phonological Fluency in School Aged Children

Resumen Las tareas de fluidez verbal semántica (FVS) y fluidez verbal fonológica (FVF) son medidas sensibles para detectar y diagnosticar diversas patologías tanto en la población adulta como en la infantil. Dado que las tareas de FVS y FVF permiten detectar problemas específicos de determinadas facultades lingüísticas o cognitivas, el objetivo de este trabajo es indagar las posibles relaciones existentes entre FVS y FVF en una población de niños argentinos de nivel escolar primario de 3°, 5° y 7° grado y edades comprendidas entre los 8 y 12 años. Los 86 niños participantes respondieron a una tarea de FVS en la que se evaluaron cinco categorías (animales, partes del cuerpo, medios de transportes, ropa e instrumentos musicales) y una tarea de FVF en la que respondieron a los fonemas /f/, /a/, /s/. Se realizó un análisis de correlaciones cuyo resultado muestra que existe una asociación de mediana intensidad entre ambas tareas. Además, se llevaron a cabo un análisis factorial exploratorio y uno confirmatorio, que detectaron dos factores diferenciados: un factor verbal semántico y un factor verbal fonológico. Los resultados obtenidos muestran que los procesos fonológicos y semánticos se encuentran diferenciados desde edades tempranas, aunque por su correlación es posible concluir que ambos procesos confluyen en un mismo almacén de búsqueda en la memoria verbal.

Abstract Semantic verbal fluency tasks (SVF) and phonological verbal fluency tasks (PVF) are highly sensitive measures used to detect and diagnose different pathologies in adult and child populations. The results of numerous investigations point out differential performances between these two tasks both in adults and children. Based on this evidence, we intend to identify the possible connections between SVF and PVF in a group of Argentinian children aged 8 to 12 years old who attended to 3rd, 5th and 7th school primary levels. Participants answered to a SVF task which tested five categories (animals and body parts for living things and transports, cloth and musical instruments for inanimate objects domain) and a PVF task where the phonemes /f, a, s/ were assessed. A correlations analysis was carried out. The result showed there is a mild association between both tasks. In addition, an exploratory factor analysis and a confirmatory factor analysis were conducted. Two differential factors were detected: a semantic verbal factor and a phonological verbal factor. Our results show that phonological and semantic are different processes and function separately in early development, although due to their correlation it is possible to conclude that both processes converge in the same store in verbal memory.

Vocal effort modulates the motor planning of short speech structures.

Speech requires programming the sequence of vocal gestures that produce the sounds of words. Here we explored the timing of this program by asking our participants to pronounce, as quickly as possible, a sequence of consonant-consonant-vowel (CCV) structures appearing on screen. We measured the delay between visual presentation and voice onset. In the case of plosive consonants, produced by sharp and well defined movements of the vocal tract, we found that delays are positively correlated with the duration of the transition between consonants. We then used a battery of statistical tests and mathematical vocal models to show that delays reflect the motor planning of CCVs and transitions are proxy indicators of the vocal effort needed to produce them. These results support that the effort required to produce the sequence of movements of a vocal gesture modulates the onset of the motor plan.

Risks for Child Cognitive Development in Rural Contexts.

While poverty all over the world is more typical and extreme in rural contexts, interventions to improve cognition in low socioeconomic status (SES) children are for the most part based on studies conducted in urban populations. This paper investigate how poverty and rural or urban settings affect child cognitive performance. Executive functions and non-verbal intelligence performance, as well as individual and environmental information was obtained from 131 5-year-old children. For the same level of SES, children in rural settings performed consistently worse than children in urban settings. These differences could be accounted mostly by the months of past preschool attendance and the father's completed level of education. These results should inform policies and programs for children living in rural poverty worldwide, and specially in Latin America.

Fluidez verbal semántica y fonológica en una muestra de niños de Argentina / Fluência semântica e fonológica em uma amostra de crianças Argentinas / Phonological and semantic verbal fluency tasks in a sample of Argentinean children

El objetivo del presente trabajo es obtener información del patrón evolutivo de desempeño en tareas de fluidez verbal para una muestra de niños argentinos de nivel primario de 3°, 5° y 7° grado. Se evaluó a los participantes con una tarea de fluidez semántica, en la que se evaluaron las categorías de animales, frutas y verduras, y partes del cuerpo para el dominio de seres vivos, y medios de transporte, instrumentos musicales y ropa para el de objetos inanimados. Asimismo fueron evaluados con una tarea de fluidez fonológica en la que se testearon los fonemas /f/, /a/ y /s/. Los datos obtenidos dan cuenta de diferencias de rendimiento entre las tareas de fluidez con un mejor desempeño en las tareas de fluidez semántica. Asimismo, en las tareas de fluidez semántica se observa un mejor rendimiento en el dominio de seres vivos. Las diferencias obtenidas en ambas tareas se identifican al comparar los grupos según escolaridad, siendo únicamente los niños de 3° grado los que, con menor cantidad de ejemplares recuperados, se disocian significativamente de los de 5° y 7° grado. Estos hallazgos son discutidos a la luz de posibles diferencias en función del desarrollo cognitivo, de las funciones ejecutivas y del sistema semántico.

No presente trabalho oferecemos dados de tarefas de fluência verbal para crianças argentinas de 3°, 5° e 7 ° ano do ensino fundamental. Os participantes foram avaliados com uma tarefa de fluência semântica, que testou as categorias de animais, frutas e legumes e partes do corpo para o domínio dos seres vivos e meios de transporte, instrumentos musicais e roupas para os objetos inanimados. As crianças também foram avaliadas com uma tarefa de fluência fonológica que testou os fonemas /f/, /a/ e /s/. Os dados obtidos apontam para diferenças de desempenho entre as tarefas e mostraram um melhor desempenho nas de fluência semântica. Além disso, nas tarefas de fluência semântica os participantes tiveram um melhor desempenho no domínio dos seres vivos. Tanto para fluência semântica quanto fonológica, as diferenças estiveram presentes quando os grupos foram comparados pelo nível de escolaridade, de modo que os alunos de 3° ano se dissociam significativamente dos 5° e 7 ° anos, produzindo menor quantidade de exemplares. Os resultados são discutidos à luz de possíveis diferenças originadas no desenvolvimento cognitivo, as funções executivas e o sistema semântico.

The aim of this work is to obtain data about the evolutionary pattern of performance in verbal fluency tasks for a sample of Argentinean primary school aged children (3rd, 5th y 7th grade) in semantic and phonological verbal fluency tasks. For the semantic fluency task, children were assessed in different categories: animals, fruits and vegetables, and body parts for living things domain, and means of transport, musical instruments and clothes for inanimate objects. For the phonological fluency assessment, children were tested with /f/, /a/and /s/phonemes. Both fluency tasks showed differences between grades, indicating the influence of education. Besides, irrespective of the grade, children performed better on the semantic fluency tasks. Results in the semantic fluency task also showed a better performance for the living things domain over the inanimate objects domain. Further analysis on the results showed that 3rd grade children have the worst performance, compared to 5th and 7th grade children. The results of our work are discussed taking in account cognitive mechanisms, executive functions and semantic memory development.

Fluidez verbal semántica y fonológica en una muestra de niños de Argentina / Fluência semântica e fonológica em uma amostra de crianças argentinas

El objetivo del presente trabajo es obtener información del patrón evolutivo de desempeño en tareas de fluidez verbal para una muestra de niños argentinos de nivel primario de 3°, 5° y 7° grado. Se evaluó a los participantes con una tarea de fluidez semántica, en la que se evaluaron las categorías de animales, frutas y verduras, y partes del cuerpo para el dominio de seres vivos, y medios de transporte, instrumentos musicales y ropa para el de objetos inanimados. Asimismo fueron evaluados con una tarea de fluidez fonológica en la que se testearon los fonemas /f/, /a/y /s/. Los datos obtenidos dan cuenta de diferencias de rendimiento entre las tareas de fluidez con un mejor desempeño en las tareas de fluidez semántica. Asimismo, en las tareas de fluidez semántica se observa un mejor rendimiento en el dominio de seres vivos. Las diferencias obtenidas en ambas tareas se identifican al comparar los grupos según escolaridad, siendo únicamente los niños de 3° grado los que, con menor cantidad de ejemplares recuperados, se disocian significativamente de los de 5° y 7° grado. Estos hallazgos son discutidos a la luz de posibles diferencias en función del desarrollo cognitivo, de las funciones ejecutivas y del sistema semántico.(AU)

No presente trabalho oferecemos dados de tarefas de fluência verbal para crianças argentinas de 3°, 5° e 7 ° ano do ensino fundamental. Os participantes foram avaliados com uma tarefa de fluência semântica, que testou as categorias de animais, frutas e legumes e partes do corpo para o domínio dos seres vivos e meios de transporte, instrumentos musicais e roupas para os objetos inanimados. As crianças também foram avaliadas com uma tarefa de fluência fonológica que testou os fonemas /f /, /a/e /s /. Os dados obtidos apontam para diferenças de desempenho entre as tarefas e mostraram um melhor desempenho nas de fluência semântica. Além disso, nas tarefas de fluência semântica os participantes tiveram um melhor desempenho no domínio dos seres vivos. Tanto para fluência semântica quanto fonológica, as diferenças estiveram presentes quando os grupos foram comparados pelo nível de escolaridade, de modo que os alunos de 3° ano se dissociam significativamente dos 5° e 7 ° anos, produzindo menor quantidade de exemplares. Os resultados são discutidos à luz de possíveis diferenças originadas no desenvolvimento cognitivo, as funções executivas e o sistema semântico.(AU)

Arithmetic on Your Phone: A Large Scale Investigation of Simple Additions and Multiplications.

We present the results of a gamified mobile device arithmetic application which allowed us to collect vast amount of data in simple arithmetic operations. Our results confirm and replicate, on a large sample, six of the main principles derived in a long tradition of investigation: size effect, tie effect, size-tie interaction effect, five-effect, RTs and error rates correlation effect, and most common error effect. Our dataset allowed us to perform a robust analysis of order effects for each individual problem, for which there is controversy both in experimental findings and in the predictions of theoretical models. For addition problems, the order effect was dominated by a max-then-min structure (i.e 7+4 is easier than 4+7). This result is predicted by models in which additions are performed as a translation starting from the first addend, with a distance given by the second addend. In multiplication, we observed a dominance of two effects: (1) a max-then-min pattern that can be accounted by the fact that it is easier to perform fewer additions of the largest number (i.e. 8x3 is easier to compute as 8+8+8 than as 3+3+…+3) and (2) a phonological effect by which problems for which there is a rhyme (i.e. "seis por cuatro es veinticuatro") are performed faster. Above and beyond these results, our study bares an important practical conclusion, as proof of concept, that participants can be motivated to perform substantial arithmetic training simply by presenting it in a gamified format.

Perceptual learning effect on decision and confidence thresholds.

Practice can enhance of perceptual sensitivity, a well-known phenomenon called perceptual learning. However, the effect of practice on subjective perception has received little attention. We approach this problem from a visual psychophysics and computational modeling perspective. In a sequence of visual search experiments, subjects significantly increased the ability to detect a "trained target". Before and after training, subjects performed two psychophysical protocols that parametrically vary the visibility of the "trained target": an attentional blink and a visual masking task. We found that confidence increased after learning only in the attentional blink task. Despite large differences in some observables and task settings, we identify common mechanisms for decision-making and confidence. Specifically, our behavioral results and computational model suggest that perceptual ability is independent of processing time, indicating that changes in early cortical representations are effective, and learning changes decision criteria to convey choice and confidence.