ABSTRACT
Changes in hemodynamics, reserve capacities of intact and damaged myocardium have been studied, with the left and right ventricular functions during mounting volume load assessed separately. It has been shown that exclusion of the part of left ventricular myocardium from contraction deteriorated considerably the pump and contractile function not only of the left but also of the right intact heart ventricle. Heart failure in volume overload manifests itself primarily in the right ventricle and depends on the functional heart reverse on the whole: in animals with partial injury of left ventricular myocardium heart failure developed in much lower volume loads than in intact animals. In circulation volume overload, left or right ventricular stroke work index to preload or filling pressure in the corresponding heart chamber ratio was most adequate and prognostically valuable for the detection of latent heart failure.
Subject(s)
Blood Volume/physiology , Heart Diseases/physiopathology , Ventricular Function, Left/physiology , Ventricular Function, Right/physiology , Animals , Dogs , Female , MaleABSTRACT
The reserve possibilities of the heart in dosed exclusion of part of the contractile myocardium of the left ventricle were determined by the initial functional condition of the "intact" myocardium. Overexertion by volume in exclusion of part of the myocardium from contraction is dangerous due to exhaustion of the myocardial contractility reserve, relative diminution of coronary circulation with the gradual increase of exertion and overloading of the lesser circulation, which are a secondary cause of the reduction of the reserve possibilities of the heart.
