Subject(s)
Calcium/blood , Seizures/blood , Child, Preschool , Electroencephalography , Female , Follow-Up Studies , Humans , Infant , Male , Prognosis , Retrospective Studies , Seizures/etiology , Seizures/physiopathology , Severity of Illness IndexABSTRACT
Effective application of anticonvulsants is among the main problems of conservative management of epilepsy in children. Pharmacokinetics of two anticonvulsants, depakin and convulex, was studied in 33 epileptic patients. Its description, based on a mathematical model, permits selection of doses and frequency of administration so that concentration of the drug remains within the therapeutical range as long as possible. Introduction of methods of analysis of individual pharmacokinetics of anticonvulsants enhances efficacy of treatment by 30 per cent in children with epileptic attacks.
Subject(s)
Anticonvulsants/pharmacokinetics , Epilepsies, Partial/drug therapy , Epilepsy, Generalized/drug therapy , Valproic Acid/pharmacokinetics , Adolescent , Anticonvulsants/administration & dosage , Child , Child, Preschool , Drug Evaluation , Drug Therapy, Combination , Epilepsies, Partial/blood , Epilepsy, Generalized/blood , Humans , Infant , Valproic Acid/administration & dosageABSTRACT
Clinical and physiological correlations were carried out on the basis of an analysis of clinical studies of vegetative dystonia (VD) and the general initial vegetative tone with determination of the mean percentage of the dominant activity, the dystonia ratio and the index of vegetative deviation devised for the first time and on the basis of studying interrelations between the synchronizing and desynchronizing systems according to the EEG readings. There were 107 children suffering from primary and secondary generalized epilepsy and 30 normal children of the same age. The patients with primary generalized epilepsy demonstrated the predominance of the activating influences of the reticular formation on brain bioelectric activity as compared to patients with secondary generalized epilepsy. This correlates with the data on the general initial vegetative tone and the clinical manifestations of VD. According to these data, the sympathetico-tonic manifestations were predominant in patients with primary generalized epilepsy, whereas the parasympathetic ones in those suffering from secondary generalized epilepsy.
Subject(s)
Autonomic Nervous System Diseases/diagnosis , Autonomic Nervous System/physiopathology , Cerebral Cortex/physiopathology , Epilepsies, Partial/physiopathology , Epilepsy, Generalized/physiopathology , Neurocirculatory Asthenia/diagnosis , Autonomic Nervous System Diseases/etiology , Autonomic Nervous System Diseases/physiopathology , Child , Child, Preschool , Electroencephalography , Epilepsies, Partial/complications , Epilepsy, Generalized/complications , Female , Humans , Male , Neurocirculatory Asthenia/etiology , Neurocirculatory Asthenia/physiopathologySubject(s)
Chorea/diagnosis , Hyperkinesis/diagnosis , Adolescent , Child , Chorea/complications , Diagnosis, Differential , Female , Humans , Hyperkinesis/complications , MaleABSTRACT
The author examined 90 children with ticose hyperkinesis. On the basis of a thorough study of the clinical picture, course of the disease and the use of laboratory methods all the patients were divided into 3 groups: with regressive, remittent and progradient development and characteristic clinical signs. For each group a corresponding treatment with a good effect was selected.
