ABSTRACT
The serum levels of cortisol and glycosaminoglycans (GAG) were studied in patients with uveitis in rheumatic diseases (RD). Among the patients with this pathology, there was a more preponderance of persons with low cortisol levels. In acute uvitis in the presence of RD, the mean serum content of this hormone was significantly lower than that in infectious and idiopathic uveitis. In RD, uveitis ran well with positive changes in the serum levels of cortisol, which increased during treatment. Its poor course was observed when the low content of cortisol remained or decreased still further. GAG exchange in uveitis patients with RD changed: there was an inverse correlation between the level of hyaluronic acid and that of cortisol (r = -0.7994; p = 0.031); the same correlation was found in males between the concentration of summary GAG and that of cortisol (r = -9832; p = 0.003) and chondroitin sulfate (r = -9965; p = 0.001).
Subject(s)
Glycosaminoglycans/blood , Hydrocortisone/blood , Rheumatic Diseases/complications , Uveitis/blood , Adult , Biomarkers/blood , Female , Follow-Up Studies , Humans , Male , Middle Aged , Radioimmunoassay , Rheumatic Diseases/blood , Severity of Illness Index , Uveitis/etiologyABSTRACT
Numerous experimental and clinical studies indicate the involvement of the renin-angiotensin system in the development and progression of diabetic organ pathology. ASD is the main biochemical mechanism by which vasomotor and angiogenic reactions are realized. It interacts closely with its antagonist, the kallikrein-kinin system. Both systems are a cascade of proteolytic reactions leading to the formation of vasoactive peptides of angiotensin II and bradykinin. These endogenous regulators have the opposite effect on hemodynamics and water-salt balance.
