Transformers in medical imaging: A survey.

Following unprecedented success on the natural language tasks, Transformers have been successfully applied to several computer vision problems, achieving state-of-the-art results and prompting researchers to reconsider the supremacy of convolutional neural networks (CNNs) as de facto operators. Capitalizing on these advances in computer vision, the medical imaging field has also witnessed growing interest for Transformers that can capture global context compared to CNNs with local receptive fields. Inspired from this transition, in this survey, we attempt to provide a comprehensive review of the applications of Transformers in medical imaging covering various aspects, ranging from recently proposed architectural designs to unsolved issues. Specifically, we survey the use of Transformers in medical image segmentation, detection, classification, restoration, synthesis, registration, clinical report generation, and other tasks. In particular, for each of these applications, we develop taxonomy, identify application-specific challenges as well as provide insights to solve them, and highlight recent trends. Further, we provide a critical discussion of the field's current state as a whole, including the identification of key challenges, open problems, and outlining promising future directions. We hope this survey will ignite further interest in the community and provide researchers with an up-to-date reference regarding applications of Transformer models in medical imaging. Finally, to cope with the rapid development in this field, we intend to regularly update the relevant latest papers and their open-source implementations at https://github.com/fahadshamshad/awesome-transformers-in-medical-imaging.

Untrained Neural Network Priors for Inverse Imaging Problems: A Survey.

In recent years, advancements in machine learning (ML) techniques, in particular, deep learning (DL) methods have gained a lot of momentum in solving inverse imaging problems, often surpassing the performance provided by hand-crafted approaches. Traditionally, analytical methods have been used to solve inverse imaging problems such as image restoration, inpainting, and superresolution. Unlike analytical methods for which the problem is explicitly defined and the domain knowledge is carefully engineered into the solution, DL models do not benefit from such prior knowledge and instead make use of large datasets to predict an unknown solution to the inverse problem. Recently, a new paradigm of training deep models using a single image, named untrained neural network prior (UNNP) has been proposed to solve a variety of inverse tasks, e.g., restoration and inpainting. Since then, many researchers have proposed various applications and variants of UNNP. In this paper, we present a comprehensive review of such studies and various UNNP applications for different tasks and highlight various open research problems which require further research.

Single-shot retinal image enhancement using untrained and pretrained neural networks priors integrated with analytical image priors.

Retinal images acquired using fundus cameras are often visually blurred due to imperfect imaging conditions, refractive medium turbidity, and motion blur. In addition, ocular diseases such as the presence of cataracts also result in blurred retinal images. The presence of blur in retinal fundus images reduces the effectiveness of the diagnosis process of an expert ophthalmologist or a computer-aided detection/diagnosis system. In this paper, we put forward a single-shot deep image prior (DIP)-based approach for retinal image enhancement. Unlike typical deep learning-based approaches, our method does not require any training data. Instead, our DIP-based method can learn the underlying image prior while using a single degraded image. To perform retinal image enhancement, we frame it as a layer decomposition problem and investigate the use of two well-known analytical priors, i.e., dark channel prior (DCP) and bright channel prior (BCP) for atmospheric light estimation. We show that both the untrained neural networks and the pretrained neural networks can be used to generate an enhanced image while using only a single degraded image. The proposed approach is time and memory-efficient, which makes the solution feasible for real-world resource-constrained environments. We evaluate our proposed framework quantitatively on five datasets using three widely used metrics and complement that with a subjective qualitative assessment of the enhancement by two expert ophthalmologists. For instance, our method has achieved significant performance for untrained CDIPs coupled with DCP in terms of average PSNR, SSIM, and BRISQUE values of 40.41, 0.97, and 34.2, respectively, and for untrained CDIPs coupled with BCP, it achieved average PSNR, SSIM, and BRISQUE values of 40.22, 0.98, and 36.38, respectively. Our extensive experimental comparison with several competitive baselines on public and non-public proprietary datasets validates the proposed ideas and framework.