ABSTRACT
A case-control epidemiologic study in squamous-cell carcinoma of the larynx (LC) vs. smoking was carried out. Although no independent influence of drinking was found, the synergetic effect of the two habits potentiated the carcinogenic impact. Approximately 87% of LC cases are attributable to tobacco use in Central and Eastern Europe. Occupational exposure to coal dust is regarded as a possible cause.
Subject(s)
Alcohol Drinking/adverse effects , Coal Mining , Laryngeal Neoplasms/etiology , Occupational Exposure/adverse effects , Smoking/adverse effects , Alcohol Drinking/epidemiology , Case-Control Studies , Europe, Eastern/epidemiology , Female , Humans , Laryngeal Neoplasms/epidemiology , Male , Risk Factors , Smoking/epidemiologyABSTRACT
The authors conducted 2 independent cohort studies on epidemiology of malignancies among workers contacting chloroprene. The first study covered morbidity and mortality with malignancies among workers engaged into polychloroprene resins production in Erevan; the second study--mortality with malignancies among Moscow shoe makers who contacted polychloroprene glues and latex. The findings are reliably higher risk of morbidity and mortality with hepatic cancer, dose--effect dependence between chloroprene exposure and occurrence of and mortality with hepatic cancer.
Subject(s)
Carcinogens/adverse effects , Chemical Industry , Chloroprene/adverse effects , Liver Neoplasms/etiology , Cohort Studies , Female , Humans , Liver Neoplasms/mortality , MaleABSTRACT
Epidemiologic study of occupational cancer covered a cohort of shoe production workers exposed to chloroprene. The cohort consists of 5058 examinees having length of service over 2 years and subjected to follow-up for 15 years. The total person-years equaled 75,000. The examinees demonstrated higher mortality with liver cancer, leukoses, pancreatic carcinoma, malignancies of central nervous system, renal cancer. The study first revealed unusual but significant risk of mortality with malignancies of mediastinum and heart (ICD-12 code is 164). The study defined a "dose-effect" correlation between exposure to chloroprene and death with liver cancer.
Subject(s)
Chloroprene/adverse effects , Neoplasms/chemically induced , Occupational Diseases/chemically induced , Occupational Exposure , Cohort Studies , Female , Follow-Up Studies , Humans , Liver Neoplasms/chemically induced , Liver Neoplasms/mortality , Male , Neoplasms/mortality , Occupational Diseases/mortality , Prognosis , Retrospective Studies , Sex Factors , Time FactorsABSTRACT
Data presented in literature proves frequent malignancies of various localizations in workers engaged into footwear production, which could result from exposure to leather, rubber dust and some chemicals (polyvinylchloride, chloroprene and others). Hygienic studies of air at footwear production demonstrate that the workers at their workplaces are exposed to such occupational hazards as dust, chemicals. Epidemiologic research to reveal possible correlation between work conditions and the workers' health are expedient.
