ABSTRACT
Objective:To compare the effect of two kinds of methods inducing ankle dorsiflexion on ankle dorsiflexion function for stroke patients. Methods:From September, 2016 to September, 2018, 60 patients with disorders of ankle active dorsiflexion after stroke were randomly divided into groups A, B and C, who accepted routine rehabilitation, tapping-zone therapy and tapping Qiuxu acupoint (GB40), respectively, for six weeks. They were assessed with three-dimensional gait analysis and surface electromyography before and after treatment. Results:The range of motion of the affected ankle, the peak torque of ankle and integrated electromyography of tibialis anterior muscle increased after treatment (t > 2.318, P < 0.05), and it ranked from best to worst as group C, group B and group A (P < 0.05). Conclusion:Both tapping-zone therapy and tapping Qiuxu may promote the recovery of ankle dorsiflexion in stroke patients, and the latter seems better.
ABSTRACT
AIM: Remote ischemic preconditioning protects against ischemic organ damage by giving short periods of subcritical ischemia to a remote organ. We tested the hypothesis that remote ischemic conditioning can attenuate cerebral stroke in a rat middle cerebral artery occlusion (MCAO) model by microparticles (MPs). METHODS AND RESULTS: MPs were extracted from healthy rats that underwent hindlimb ischemia-reperfusion preconditioning (RIPC), and were transfused into rats that had undergone MCAO without RIPC. The transfusion resulted in an increase in platelet-derived MPs in blood and reduction in infarction area, confirmed by both 2-3-5-triphenyltetrazolium chloride staining and magnetic resonance imaging, albeit to a lesser degree than RIPC itself. Behavioral tests (modified Neurological Severity Score [mNSS]) were calculated to judge the behavioral change. However, no significant difference was observed after MP transfusion in 24 h or the following consecutive 9 days. CONCLUSIONS: RIPC induces an increase in MPs, and platelet-derived MPs may confer at least part of the remote protective effect against cerebral ischemic-reperfusion injury.
Subject(s)
Cell-Derived Microparticles/pathology , Cerebral Infarction/etiology , Cerebral Infarction/prevention & control , Infarction, Middle Cerebral Artery/complications , Ischemic Preconditioning , Animals , Cell-Derived Microparticles/ultrastructure , Disease Models, Animal , Endothelial Cells/pathology , Flow Cytometry , Male , Microscopy, Electron, Transmission , Nervous System Diseases/diagnosis , Nervous System Diseases/etiology , Platelet Membrane Glycoprotein IIb/metabolism , Rats , Rats, Sprague-Dawley , Upper Extremity/physiopathologyABSTRACT
<p><b>OBJECTIVE</b>To probe into using evidence-based medicine to establish TCM stroke unit, so as to serve for clinical treatment of apoplexy.</p><p><b>METHODS</b>Based on basic theories of TCM and in referred to the stroke unit model with therapeutic effect confirmed by evidence-based medicine, TCM stroke unit with characteristics of acupuncture and moxibustion was established.</p><p><b>CONCLUSION</b>Establishment of TCM stroke unit with TCM characteristics is objective in future, but it still needs high quality of clinical evidences.</p>
