[Postoperative wound complications in cardiosurgery].

Presented in the article are the results of examination and treatment of 65 patients with infectious wound complications of the sternotomic injury after open heart surgery. The main risk factors for their development in our patients were as follows: obesity, chronic obstructive pulmonary disease, diabetes mellitus, severe heart failure, prolonged operation, sternal instability. The leading pathogenic microorganisms were Gram positive staphylococci. Treatment varied from prolonged antibiotic therapy with surgical debridement of the wound to subtotal resection of the sternum with various plastic reconstructive interventions. The scope of treatment was determined by the type and severity of infectious wound complications. Due to lack of standardized approaches in diagnosis, treatment and prevention this problem remains to be of current importance.

[Treatment of purulonecrotic forms of diabetic foot in multipurpose hospital unit].

Results of treatment and inspection of 278 patients with purulonecrotic complications of diabetic foot, treated in septic surgery department of 3rd Central Military-Clinical Hospital n. a. A.A. Vishnevsky during 1999-2009 are analyzed. For patients with purulonecrotic forms of diabetic foot is necessary to perform complex therapy with participation of endocrinologist and angiosurgeon, in specialized departments with the necessary medical equipment and dressing means and having experience of treatment of patients with diabetic foot, characterized with heavy and long-lasting course of disease leading to amputations. At the same time, application of gelling dressing means, iodoforms with ferment drapes for local treatment allowed to lower a level of amputations from 17.1 to12.8%, and also to reduce stay of patients in a hospital to 8 days.

[Development of new biologically active dressings and methodology of their use]. / Razrabotka novykh biologicheski aktivnykh pereviazochnykh sredstv i metodologiia ikh primeneniia.

Results of development of new biologically active dressings and up-to-date methodology of local treatment of wounds (based on their differential application according to phase and features of wound process) are demonstrated. Data about main properties and specific activity of new biologically active dressings based on natural and synthetic polymers with immobilized drugs are presented. Future trends and efficacy of their appliance in complex treatment of purulent and necrotic wounds are demonstrated.

[Sulacillin (a combination of ampicillin and sulbactam)--a new combined drug form for treatment of bacterial infections]. / Sulatsillin (sochetanie ampitsillina s sul'baktamom)--novaia kombinirovannaia lekarstvennaia forma dlia lecheniia bakterial'nykh infektsii.

The results of the cooperated clinical trial of sulacillin, a formulation including sodium ampicillin and sulbactam (2:1), are presented. The trial was carried out in different hospitals of Moscow and Smolensk. Rapid development of the favourable time course and recovery were stated in 93.7 per cent of the cases with upper and lower respiratory tract infections, urinary and biliferous tract infections, infections of the skin and soft tissues, gynecological infections and severe suppurative complications after surgical operations. Sulacillin is useful in the empirical therapy of purulent inflammatory diseases before the pathogen isolation and identification.