Relationship between estrogen receptor 1 gene polymorphisms and postmenopausal osteoporosis of the spine in Chinese women.

The purpose of this study was to evaluate single nucleotide polymorphism (SNP) variants of the estrogen receptor 1 gene (ESR1) at rs2234693 and rs9340799, as well as to investigate the relationship between ESR gene polymorphisms and postmenopausal osteoporosis (OP) of the spine in Chinese women. We recruited 198 postmenopausal women with OP and 276 healthy women between May 2012 and September 2015 in Zhongshan Hospital. Dual energy x-ray absorptiometry was used to measure the bone mineral density (BMD) of the lumbar vertebrae in all subjects. In addition, PCR-restriction fragment length polymorphism based analysis was conducted to identify the genotypes of ESR1. The distribution of ESR1 in the osteoporosis group and the control group was determined; the relationship between ESR polymorphisms and BMD was analyzed. The distributions of BMD were: TT < TC < CC, GG < AG < AA. The TT, TTGG, and TCGG genotypes were found to be lower as compared to the other genotypes. Stratified analysis suggested that the TT genotype and the combined genotypes TTGG and TCGG were significantly higher in the OP group as compared to the control group (P < 0.01). Therefore, ESR1 polymorphisms at rs2234693 and rs9340799 may be associated with OP, and could be used as markers to screen those with high risks to postmenopausal OP in Chinese women.

Some aspects of diabetes care in Chengdu.

The great impact of diabetes mellitus (DM) on the development of China economically and sociomedically was firstly recognized by knowing the overall prevalence of the disease being 0.67% in the whole country from a nationwide cooperative survey in 1980. Shortly after the cooperative survey an epidemiological study carried out in Chengdu yielded a prevalence in DM of 1.12%, which was almost double the overall prevalence and slightly higher than that of Beijing (1.10%)--the highest one among the 14 places in the cooperative study. Increasing prevalence of DM is a general trend. Over the past decade the incidence of diabetes in hospitalized patients at the First University Hospital, WCUMS, increased from 5.7 to 13.54 per thousand. Factors that fluence the increment of prevalence of DM include increase of total calorie intake (2680 kcal/day in 1990--close to the average world level), inappropriate high carbohydrate diet habit, change of life style, e.g. urbanization, mental stress, and ageing of the population. Primary and secondary care conducted in recent decades involve nutritional intervention, education via news media and workshop, foundation of prevention networks and providing better clinical and laboratory services, etc. Future improvement of diabetes care in this region is determined by activation of the public, motivation of the policy makers, more effective education and propagation by an influenced organization, fund support, man power and resources development, and domestic and international communications and collaborations.