ABSTRACT
Hyperlipidemia is a key risk factor for cardiovascular disease, and it is associated with lipid metabolic disorders and gut microbiota dysbiosis. Here, we aimed to investigate the beneficial effects of 3-month intake of a mixed probiotic formulation in hyperlipidemic patients (n = 27 and 29 in placebo and probiotic groups, respectively). The blood lipid indexes, lipid metabolome, and fecal microbiome before and after the intervention were monitored. Our results showed that probiotic intervention could significantly decrease the serum levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol (P < 0.05), while increasing the levels of high-density lipoprotein cholesterol (P < 0.05) in patients with hyperlipidemia. Probiotic recipients showing improved blood lipid profile also exhibited significant differences in their lifestyle habits after the 3-month intervention, with an increase in daily intake of vegetable and dairy products, as well as weekly exercise time (P < 0.05). Moreover, two blood lipid metabolites (namely, acetyl-carnitine and free carnitine) significantly increased after probiotic supplementation cholesterol (P < 0.05). In addition, probiotic-driven mitigation of hyperlipidemic symptoms were accompanied by increases in beneficial bacteria like Bifidobacterium animalis subsp. lactis and Lactiplantibacillus plantarum in patients' fecal microbiota. These results supported that mixed probiotic application could regulate host gut microbiota balance, lipid metabolism, and lifestyle habits, through which hyperlipidemic symptoms could be alleviated. The findings of this study urge further research and development of probiotics into nutraceuticals for managing hyperlipidemia. IMPORTANCE The human gut microbiota have a potential effect on the lipid metabolism and are closely related to the disease hyperlipidemia. Our trial has demonstrated that 3-month intake of a mixed probiotic formulation alleviates hyperlipidemic symptoms, possibly by modulation of gut microbes and host lipid metabolism. The findings of the present study provide new insights into the treatment of hyperlipidemia, mechanisms of novel therapeutic strategies, and application of probiotics-based therapy.
Subject(s)
Bifidobacterium animalis , Gastrointestinal Microbiome , Hyperlipidemias , Probiotics , Humans , Carnitine/pharmacology , Cholesterol , Hyperlipidemias/drug therapy , Hyperlipidemias/metabolism , Life Style , Lipid Metabolism , LipidsABSTRACT
A typical serial manipulator consists of a servo motor, a serial mechanism and an independent joint placed between the motor and the serial mechanism. Both the time-varying characteristics of the inertia of the serial mechanism and the flexibility characteristics of the independent joint are widely found in serial manipulator servo drive systems. These two characteristics not only increase the resonance magnitude of serial manipulators, but also affect the dynamic characteristics of the system. In order to obtain a stable output speed of serial manipulators, the variable parameters of a PI control strategy is applied to a serial manipulator servo drive system. Firstly, dynamic model of a serial manipulator servo drive system is established based on a two-inertia system. Then the transfer function from motor speed to motor electromagnetic torque is derived by the state-space equation. Furthermore, the parameters of the PI controller are designed and optimized utilizing three different pole assignment strategies with the identical radius, the identical damping coefficients, and the identical real parts. The results indicate that a serial manipulator servo drive system can obtain good dynamic characteristics by selecting parameters of the PI controller appropriately.
