[Expression of substance P and vascular endothelial growth factor in human normal and inflammatory dental pulps].

PURPOSE: To investigate the expression and relationship of substance P(SP) and vascular endothelial growth factor (VEGF) in human dental pulp under the normal and pathological conditions, so as to study their role in pulp microcirculation. METHONDS: Ten teeth extracted for orthodontic or impacted reason were chosen as normal group. Twenty-nine traumatic teeth from the same age group needing root canal therapy were divided to initial-stage trauma group, early-stage inflammation group, later-stage inflammation group. Immunohistochemical technique was applied to determine the expression and distribution of SP and VEGF in each group. The data was analyzed by one-way ANOVA and correlation analysis with SPSS13.0 software package. RESULTS: Compared with normal group,SP expression in other groups was significantly down-regulated(P<0.05). The VEGF expression in early-stage inflammation group was significantly up-regulated compared with the other groups (P<0.05), but down-regulated in later-stage inflammation group (P<0.05). The expression of SP and VEGF had negative correlation in different groups(r=-0.378,P<0.05). CONCLUSIONS: SP may induce the pulp microcirculation change by regulating VEGF, and participate in pulp neurogenic inflammation.

[Experience introduction of induced eruption on multiple adjacent impacted teeth in anterior maxillary bone].

OBJECTIVE: To study the method of induced eruption on multiple adjacent impacted teeth in anterior maxillary bone. METHODS: Twenty-two multiple adjacent impacted teeth of 9 cases were chosen. The position of the impacted teeth and the relationship to each other were assessed on X-ray images, oral examination and plaster model. The impacted teeth were extracted or induced erupted with the closed-eruption technique and fixed orthodontic appliances. RESULTS: Of 22 impacted teeth, 19 impacted teeth were moved into arches by induced eruption with the closed-eruption technique and fixed orthodontic appliances. There were not root adsorption or conglutination for 19 impacted teeth. Three impacted teeth with deformed root were extracted. The average time for treatment was 19 months. CONCLUSION: With correct diagnosis, reasonable design, the complicated impacted teeth could be moved into alignment with good esthetic and functional effect.

[Comparison of the clinical therapeutic effects between local injection of pingyangmycin and sodium morrhuate on oral and maxillofacial venous malformation].

OBJECTIVE: To observe and compare the curative effect of pingyangmycin and sodium morrhuae respectively in the treatment of oral and maxillofacial venous malformation. METHODS: Forty cases of oral and maxillofacial venous malformation were induced in this study, 20 of which were given local injection of low dose of pingyangmycin, and 20 given local injection of 5% sodium morrheate. The therapeutic effects were observed. RESULTS: The effective cases of pingyangmycin was 19, and the effective cases of sodium morrhuate was 12. The side effect was found in 10 cases of, and in 15 cases sodium morrhuate group, the former was mainly pingymangmycin group systemic, the later was mainly local. The difference was significant between the two groups (P < 0.05). CONCLUSIONS: Pingyangmycin is more effective in effective rate and side effect treatment of venous hemangioma than sodium morrhuate.