ABSTRACT
The possibility of using solid supports and intermittent substrate feeding to manipulate biotransformation by fungi was examined, with amoxapine as a model compound. Cunninghamella elegans ATCC 8688a grown as free cells in six-well plates showed 7-hydroxyamoxapine as the major metabolite of amoxapine biotransformation. However, when cells were grown in the presence of activated carbon, N-formyl-7-hydroxyamoxapine was formed as the major metabolite. Intermittent feeding of amoxapine also favored the formation of N-formyl-7-hydroxyamoxapine.
Subject(s)
Amoxapine/metabolism , Cunninghamella/metabolism , Amoxapine/analogs & derivatives , Antidepressive Agents, Second-Generation/metabolism , Biotransformation , Chromatography, High Pressure Liquid , Cunninghamella/growth & development , Mass SpectrometryABSTRACT
A comprehensive taxonomic re-evaluation was performed on the marine, zeaxanthin-producing bacterium formerly classified as [Favobacterium] sp. strain R-1 512 (ATCC 21588). This strain, together with two other previously described marine isolates, [Flavobacterium] strain R-1506 and Paracoccus sp. strain MBIC 3966, were found to comprise a new species of the genus Paracoccus. The name Paracoccus zeaxanthinifaciens sp. nov. is proposed, with ATCC 21588T (= R-1512T =LMG 21293T) designated as the type strain.
