1.
Indian J Ophthalmol
; 69(8): 2111-2115, 2021 08.
Article
in English
| MEDLINE
| ID: mdl-34304188
ABSTRACT
Purpose: This study is aimed to investigate the presence of Human papillomavirus (HPV) DNA in tumors obtained from sporadic retinoblastoma patients. Methods: One hundred six tumor tissues obtained from sporadic RB patients were analyzed for HPV infection by use of both seminested PCR and real-time quantitative PCR. Results: Of 106 RB patients, 55 were male and 51 were female. The mean age at diagnosis was 26.77 ± 15.36 (mean ± Std. dev) months. Almost all patients presented with leukocoria. Molecular investigation by different methods revealed no HPV positivity in any tumor genome. Conclusion: Our study demonstrates no association between HPV and RB, postulating HPV may not be a major risk factor in the etiology of RB.
Subject(s)
Alphapapillomavirus , Papillomavirus Infections , Retinal Neoplasms , Retinoblastoma , Female , Humans , India/epidemiology , Male , Papillomaviridae/genetics , Papillomavirus Infections/diagnosis , Papillomavirus Infections/epidemiology , Real-Time Polymerase Chain Reaction , Retinal Neoplasms/diagnosis , Retinal Neoplasms/epidemiology , Retinoblastoma/diagnosis , Retinoblastoma/epidemiology
2.
Pediatr Blood Cancer
; 68(1): e28553, 2021 01.
Article
in English
| MEDLINE
| ID: mdl-32672397