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1.
Kaohsiung J Med Sci ; 35(8): 493-500, 2019 Aug.
Article in English | MEDLINE | ID: mdl-31087766

ABSTRACT

The role of the voltage-gated sodium channel 1.7 (Nav1.7) is unclear in models of neuropathic pain induced by nerve injury. In the present study, we measured expression levels of Nav1.7 in two distinct neuropathic pain models: spinal nerve ligation (SNL) and chronic constriction injury (CCI). In the SNL model, both mRNA and protein levels of Nav1.7 were markedly lower in the L5 dorsal root ganglia (DRG) but were significantly higher in the L4 DRG. Nav1.7 protein levels were notably higher in both L4 and L5 DRGs under CCI conditions. We found that excessive damage of L5 nerves such as SNL reduced expression levels of Nav1.7 in the injured L5 DRG and activated the adjacent uninjured DRG, resulting in Nav1.7 level increases in the adjacent L4 DRG. We confirmed again that Nav1.7 was closely related to neuropathic pain induced by nerve injury. More importantly, our results suggest that tracing the molecular changes exclusively in the L5 DRG in SNL model may not completely explain the pain mechanism; it is necessary to study the adjacent uninjured L4 DRG.


Subject(s)
Ganglia, Spinal/metabolism , NAV1.7 Voltage-Gated Sodium Channel/metabolism , Neuralgia/metabolism , Neuralgia/pathology , Spinal Nerves/metabolism , Spinal Nerves/pathology , Animals , Constriction, Pathologic , Disease Models, Animal , Ligation , Male , Neuralgia/etiology , Rats, Sprague-Dawley
3.
Arch Dermatol Res ; 302(4): 315-7, 2010 May.
Article in English | MEDLINE | ID: mdl-20300938

ABSTRACT

Acrodermatitis enteropathica, a rare autosomal recessive disease, manifests as periorificial and symmetrical acral dermatitis, alopecia, and diarrhea due to insufficient zinc uptake by the intestine. Recent research revealed that mutations in the SLC39A4 gene are responsible for acrodermatitis enteropathica. This gene encodes one member of a human zinc transporter-like protein, also known as ZIP4. We detected one novel homozygous mutation c.1115T > G in the human SLC39A4 gene in one Chinese patient, which leading to p.L372R of the ZIP4. Homology analysis shows Leu372 in ZIP4 is conserved in Eutheria.


Subject(s)
Acrodermatitis/genetics , Cation Transport Proteins/genetics , Acrodermatitis/diagnosis , Acrodermatitis/drug therapy , Acrodermatitis/physiopathology , Adolescent , Alopecia , Cation Transport Proteins/metabolism , China , DNA Mutational Analysis , Diarrhea , Erythema , Female , Homozygote , Humans , Mutation/genetics , Pedigree , Zinc/deficiency , Zinc Sulfate/therapeutic use
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