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1.
Adv Mater ; 36(15): e2308217, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38198412

ABSTRACT

Topical therapy is a favored route for treating skin cancers, but remain many challenges, such as low delivery efficiency, limited tumor tissue penetration, and unsatisfactory blood circulation. Here, a self-heating microneedle (MN) patch with multilevel structures, including a dissolvable base for rapid drug release, a degradable tip for sustained drug release, and a self-heating substrate is described. The thermally enhanced drug release performance is validated through both in vitro and in vivo experiments. High tumor therapeutic efficacy can be achieved due to the rapid release of 5-fluorouracil, while the sustained release of thymoquinone endows the MN patch with long-term tumor inhibition ability. It is further demonstrated the feasibility of such an MN patch for in vivo topical therapy of cutaneous squamous cell carcinoma with high efficacy, low side effects, and long-term inhibition of recurrence. This self-heating MN patch holds great promise for potential clinical applications, especially for the treatment of skin cancers.


Subject(s)
Carcinoma, Squamous Cell , Skin Neoplasms , Humans , Skin Neoplasms/drug therapy , Skin Neoplasms/pathology , Heating , Drug Delivery Systems , Pharmaceutical Preparations , Skin/pathology
2.
Adv Healthc Mater ; 11(23): e2202126, 2022 12.
Article in English | MEDLINE | ID: mdl-36165220

ABSTRACT

As a prominent class of 2D transition metal dichalcogenides (TMDCs), niobium diselenide nanosheets (NbSe2 NSs) have garnered tremendous interest on account of promising applications pertaining to optoelectronics and energy storage. Although NbSe2 NSs have many unique advantages such as inherent biocompatibility and broad absorption in the NIR region, their biomedical applications have rarely been reported, especially as therapeutic agents for the second near-infrared (NIR-II) range. Herein, a biodegradable nanotherapeutic platform consisting of NbSe2 NSs is designed and demonstrated for NIR-II light-triggered photothermal therapy. NbSe2 NSs synthesized by grinding and liquid exfoliation exhibit superior photothermal conversion efficiency (48.3%) and remarkable photothermal stability in the NIR-II region. In vitro assessment demonstrates that NbSe2 NSs have favorable photothermal cell ablation efficiency and biocompatibility. After intravenous injection in vivo, the NbSe2 NSs accumulate passively in tumor sites to facilitate fluorescence imaging and tumor ablation by NIR-II illumination. Furthermore, as a result of gradual degradation in the physiological environment, NbSe2 NSs can be excreted from the body to avoid potential toxicity caused by long-term retention in vivo. The results reveal a promising NIR-II light-triggered PTT strategy with the aid of NbSe2 NSs and the platform is expected to have large potential in cancer theranostics.


Subject(s)
Neoplasms , Niobium , Humans , Niobium/pharmacology , Neoplasms/diagnostic imaging , Neoplasms/drug therapy
3.
Sci Rep ; 12(1): 3592, 2022 03 04.
Article in English | MEDLINE | ID: mdl-35246558

ABSTRACT

Head and neck cancer is the sixth most common cancer in the world, with more than 300,000 deaths attributed to the disease annually. Aggressive surgical resection often with adjuvant chemoradiation is the cornerstone of treatment. However, the necessary chemoradiation treatment can result in collateral damage to adjacent vital structures causing a profound impact on quality of life. Here, we present a novel polymer of poly(lactic-co-glycolic) acid and polyvinyl alcohol that can serve as a versatile multidrug delivery platform as well as for detection on cross-sectional imaging while functioning as a fiduciary marker for postoperative radiotherapy and radiotherapeutic dosing. In a mouse xenograft model, the dual-layered polymer composed of calcium carbonate/thymoquinone was used for both polymer localization and narrow-field infusion of a natural therapeutic compound. A similar approach can be applied in the treatment of head and neck cancer patients, where immunotherapy and traditional chemotherapy can be delivered simultaneously with independent release kinetics.


Subject(s)
Head and Neck Neoplasms , Polymers , Animals , Chemoradiotherapy, Adjuvant , Head and Neck Neoplasms/therapy , Humans , Mice , Polymers/chemistry , Quality of Life
6.
Adv Sci (Weinh) ; 7(14): 2000439, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32714754

ABSTRACT

The photochemical activity of black phosphorus (BP) in near-infrared (NIR) light controlled in situ biomineralization is investigated. Owing to the excellent NIR absorption, irradiation with NIR light not only promotes degradation of BP into PO4 3-, but also enhances the chemical activity to accelerate the reaction between PO4 3- and Ca2+ and promote in situ biomineralization. Mineralization of hydrogels is demonstrated by the preparation of BP incorporated hydrogel (BP@Hydrogel) which delivers greatly improved biomineralization performance under NIR illumination. The biomineralization process which can be controlled by modulating the light irradiation time and location has a high potential in controlling the mechanical properties and osteoinductive ability in tissue engineering. This study also provides insights into the degradation, photochemical activity, and new biological/biomedical applications of BP.

7.
Small ; 16(1): e1905208, 2020 01.
Article in English | MEDLINE | ID: mdl-31805221

ABSTRACT

As new 2D layered nanomaterials, Bi2 O2 Se nanoplates have unique semiconducting properties that can benefit biomedical applications. Herein, a facile top-down approach for the synthesis of Bi2 O2 Se quantum dots (QDs) in a solution is described. The Bi2 O2 Se QDs with a size of 3.8 nm and thickness of 1.9 nm exhibit a high photothermal conversion coefficient of 35.7% and good photothermal stability. In vitro and in vivo assessments demonstrate that the Bi2 O2 Se QDs possess excellent photoacoustic (PA) performance and photothermal therapy (PTT) efficiency. After systemic administration, the Bi2 O2 Se QDs accumulate passively in tumors enabling efficient PA imaging of the entire tumors to facilitate imaging-guided PTT without obvious toxicity. Furthermore, the Bi2 O2 Se QDs which exhibit degradability in aqueous media not only have sufficient stability during in vivo circulation to perform the designed therapeutic functions, but also can be discharged harmlessly from the body afterward. The results reveal the great potential of Bi2 O2 Se QDs as a biodegradable multifunctional agent in medical applications.


Subject(s)
Bismuth/therapeutic use , Neoplasms/therapy , Organoselenium Compounds/therapeutic use , Photoacoustic Techniques/methods , Phototherapy/methods , Quantum Dots , Bismuth/chemistry , Cell Line, Tumor , Humans , Organoselenium Compounds/chemistry , Powder Diffraction , Selenium Compounds , Spectrophotometry, Ultraviolet , Spectroscopy, Near-Infrared
8.
ACS Sens ; 4(9): 2303-2310, 2019 09 27.
Article in English | MEDLINE | ID: mdl-31385492

ABSTRACT

A reliable surface-enhanced Raman scattering (SERS) substrate composed of two-dimensional (2D) MXene (Ti3C2Tx) nanosheets and gold nanorods (AuNRs) is designed and fabricated for sensitive detection of organic pollutants. The AuNRs are uniformly distributed on the surface of the 2D MXene nanosheets because of the strong electrostatic interactions, forming abundant SERS hot spots. The MXene/AuNR SERS substrate exhibits high sensitivity and excellent reproducibility in the determination of common organic dyes such as rhodamine 6G, crystal violet, and malachite green. The detection limits are 1 × 10-12, 1 × 10-12, and 1 × 10-10 M, and relative standard deviations determined from 13 areas on each sample are 18.1, 10.1, and 15.6%, respectively. In the determination of more complex organic pesticides and pollutants, the substrate also shows excellent sensitivity and quantitative detection, and the detection limits for thiram and diquat of 1 × 10-10 and 1 × 10-8 M, respectively, are much lower than the contaminant levels stipulated by the US Environmental Protection Agency. The MXene/AuNR composite constitutes an efficient SERS platform for reliable and high-sensitivity environmental analysis and food safety monitoring.


Subject(s)
Environmental Pollutants/analysis , Gold/chemistry , Nanotubes/chemistry , Organic Chemicals/analysis , Spectrum Analysis, Raman/methods , Static Electricity , Titanium/chemistry , Coloring Agents/analysis , Limit of Detection , Models, Molecular , Molecular Conformation
9.
Nano Lett ; 19(8): 5587-5594, 2019 08 14.
Article in English | MEDLINE | ID: mdl-31260628

ABSTRACT

In breast cancer chemophotothermal therapy, it is a great challenge for the development of multifunctional nanoagents for precision targeting and the effective treatment of tumors, especially for metastasis. Herein, we successfully design and synthesize a multifunctional black phosphorus (BP)-based nanoagent, BP/DTX@PLGA, to address this challenge. In this composite nanoagent, BP quantum dots (BPQDs) are loaded into poly(lactic-co-glycolic acid) (PLGA) with additional conjugation of a chemotherapeutic agent, docetaxel (DTX). The in vivo distribution results demonstrate that BP/DTX@PLGA shows striking tropism for targeting both primary tumors and lung metastatic tumors. Moreover, BP/DTX@PLGA exhibits outstanding controllable chemophotothermal combinatory therapeutics, which dramatically improves the efficacy of photothermal tumor ablation when combined with near-light irradiation. Mechanistically, accelerated DTX release from the nanocomplex upon heating and thermal treatment per se synergistically incurs apoptosis-dependent cell death, resulting in the elimination of lung metastasis. Meanwhile, in vitro and in vivo results further confirm that BP/DTX@PLGA possesses good biocompatibility. This study provides a promising BP-based multimodal nanoagent to constrain cancer metastasis.


Subject(s)
Antineoplastic Agents/therapeutic use , Docetaxel/therapeutic use , Mammary Neoplasms, Animal/therapy , Nanoconjugates/therapeutic use , Phosphorus/therapeutic use , Animals , Antineoplastic Agents/pharmacokinetics , Docetaxel/pharmacokinetics , Female , Lung Neoplasms/pathology , Lung Neoplasms/secondary , Lung Neoplasms/therapy , Mammary Neoplasms, Animal/pathology , Mice , Neoplasm Metastasis/pathology , Neoplasm Metastasis/therapy , Phosphorus/pharmacokinetics , Polylactic Acid-Polyglycolic Acid Copolymer/pharmacokinetics , Polylactic Acid-Polyglycolic Acid Copolymer/therapeutic use
10.
Biomaterials ; 179: 164-174, 2018 10.
Article in English | MEDLINE | ID: mdl-29986234

ABSTRACT

A near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl2 and BP nanosheets (BPs) into poly(lactic-co-glycolic acid) (PLGA) for bone regeneration. The fabricated BP-SrCl2/PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. The NIR-triggered release behavior of Sr2+ by flawing the PLGA shells is investigated and the microspheres exhibit excellent cell viability and biodegradability. Implantation of the BP-SrCl2/PLGA microspheres into a rat femoral defect demonstrates good tissue compatibility and excellent bone regeneration capacity under NIR light irradiation. Our study indicates that local release of Sr2+ at optimal time periods controlled by NIR irradiation improves bone regeneration significantly and this NIR-triggered drug delivery system composed of BPs is suitable for therapies requiring precise control at specific time.


Subject(s)
Phosphorus/chemistry , Bone Regeneration/physiology , Drug Delivery Systems/methods , Infrared Rays , Polyglycolic Acid/chemistry , Polylactic Acid-Polyglycolic Acid Copolymer/chemistry
11.
Adv Sci (Weinh) ; 5(5): 1700848, 2018 May.
Article in English | MEDLINE | ID: mdl-29876210

ABSTRACT

Photothermal therapy (PTT) is a fledgling therapeutic strategy for cancer treatment with minimal invasiveness but clinical adoption has been stifled by concerns such as insufficient biodegradability of the PTT agents and lack of an efficient delivery system. Here, black phosphorus (BP) nanosheets are incorporated with a thermosensitive hydrogel [poly(d,l-lactide)-poly(ethylene glycol)-poly(d,l-lactide) (PDLLA-PEG-PDLLA: PLEL)] to produce a new PTT system for postoperative treatment of cancer. The BP@PLEL hydrogel exhibits excellent near infrared (NIR) photothermal performance and a rapid NIR-induced sol-gel transition as well as good biodegradability and biocompatibility in vitro and in vivo. Based on these merits, an in vivo PTT postoperative treatment strategy is established. Under NIR irradiation, the sprayed BP@PLEL hydrogel enables rapid gelation forming a gelled membrane on wounds and offers high PTT efficacy to eliminate residual tumor tissues after tumor removal surgery. Furthermore, the good photothermal antibacterial performance prevents infection and this efficient and biodegradable PTT system is very promising in postoperative treatment of cancer.

12.
Biomaterials ; 164: 11-21, 2018 05.
Article in English | MEDLINE | ID: mdl-29477708

ABSTRACT

In this paper, we propose a new shape memory polymer (SMP) composite with excellent near-infrared (NIR)-photoresponsive shape memory performance and biodegradability. The composite is fabricated by using piperazine-based polyurethane (PU) as thermo-responsive SMP incorporated with black-phosphorus (BP) sheets as NIR photothermal nanofillers. Under 808 nm light irradiation, the incorporated BP sheets with concentration of only 0.08 wt% enable rapid temperature increase over the glass temperature of PU and trigger the shape change of the composite with shape recovery rate of ∼100%. The in vitro and in vivo toxicity examinations demonstrate the good biocompatibility of the PU/BP composite, and it degrades naturally into non-toxic carbon dioxide and water from PU and non-toxic phosphate from BP. By implanting PU/BP columns into back subcutis and vagina of mice, they exhibit excellent shape memory activity to change their shape quickly under moderate 808 nm light irradiaiton. Such SMP composite enable the development of intelligent implantable devices, which can be easily controlled by the remote NIR light and degrade gradually after performing the designed functions in the body.


Subject(s)
Absorbable Implants , Biocompatible Materials , Phosphorus , Animals , Biocompatible Materials/chemistry , Female , Humans , Mice , Nanostructures/chemistry
13.
ACS Appl Mater Interfaces ; 10(1): 1155-1163, 2018 Jan 10.
Article in English | MEDLINE | ID: mdl-29232107

ABSTRACT

One of the clinical challenges facing photothermal cancer therapy is health risks imposed by the photothermal nanoagents in vivo. Herein, a photothermal therapy (PTT) platform composed of a 2D material-based nanofibrous membrane as the agent to deliver thermal energy to tumors under near-infrared (NIR) light irradiation is described. The photothermal membrane, which is fabricated by an electrospinning poly(l-lactic acid) (PLLA) nanofibrous membrane loaded with bismuth selenide (Bi2Se3) nanoplates, exhibits very high photothermal conversion efficiency and long-term stability. Cell experiments and hematological analyses demonstrate that the Bi2Se3/PLLA membranes have excellent biocompatibility and low toxicity. PTT experiments performed in vivo with the Bi2Se3/PLLA membrane covering the tumor and NIR irradiation produce local hyperthermia to ablate the tumor with high efficiency. Different from the traditional systematical and local injection techniques, this membrane-based PTT platform is promising in photothermal cancer therapy, especially suitable for the treatment of multiple solid tumors or skin cancers, and long-term prevention of cancer recurrence after surgery or PTT, while eliminating the health hazards of nanoagents.


Subject(s)
Nanofibers , Humans , Hyperthermia, Induced , Neoplasms , Phototherapy
14.
Biomaterials ; 133: 37-48, 2017 07.
Article in English | MEDLINE | ID: mdl-28426974

ABSTRACT

Two of the challenges for clinical implementation of nano-therapeutic strategies are optimization of tumor targeting and clearance of the nanoagents in vivo. Herein, a cell-mediated therapy by transporting 2D Bi2Se3 nanosheets within macrophage vehicles is described. The Bi2Se3 nanosheets with excellent near-infrared photothermal performance exhibit high macrophage uptake and negligible cytotoxicity thus facilitating the fabrication of Bi2Se3-laden-macrophages. Compared with bare Bi2Se3, the Bi2Se3-laden-macrophages after intravenous injection show prolonged blood circulation and can overcome the hypoxia-associated drug delivery barrier to target the tumor efficiently and dramatically enhance the efficiency of photothermal cancer therapy. The Bi2Se3-laden-macrophages possess good biocompatibility as demonstrated by the biochemical and histological analyses and furthermore, most of the materials are excreted from the body within 25 days. Our findings reveal a desirable system for highly efficient near-infrared photothermal cancer therapy.


Subject(s)
Nanostructures/chemistry , Nanostructures/therapeutic use , Phototherapy/methods , Animals , Cell Proliferation/drug effects , Female , Humans , Hyperthermia, Induced/methods , Infrared Rays , MCF-7 Cells , Mammary Neoplasms, Animal/therapy , Mice , Mice, Inbred BALB C , Mice, Nude , Nanoparticles/chemistry , RAW 264.7 Cells
15.
Nat Commun ; 7: 12967, 2016 Sep 30.
Article in English | MEDLINE | ID: mdl-27686999

ABSTRACT

Photothermal therapy (PTT) offers many advantages such as high efficiency and minimal invasiveness, but clinical adoption of PTT nanoagents have been stifled by unresolved concerns such as the biodegradability as well as long-term toxicity. Herein, poly (lactic-co-glycolic acid) (PLGA) loaded with black phosphorus quantum dots (BPQDs) is processed by an emulsion method to produce biodegradable BPQDs/PLGA nanospheres. The hydrophobic PLGA not only isolates the interior BPQDs from oxygen and water to enhance the photothermal stability, but also control the degradation rate of the BPQDs. The in vitro and in vivo experiments demonstrate that the BPQDs/PLGA nanospheres have inappreciable toxicity and good biocompatibility, and possess excellent PTT efficiency and tumour targeting ability as evidenced by highly efficient tumour ablation under near infrared (NIR) laser illumination. These BP-based nanospheres combine biodegradability and biocompatibility with high PTT efficiency, thus promising high clinical potential.

16.
Small ; 12(30): 4136-45, 2016 Aug.
Article in English | MEDLINE | ID: mdl-27329254

ABSTRACT

Poly(vinylpyrrolidone)-encapsulated Bi2 Se3 nanosheets with a thickness of 1.7 nm and diameter of 31.4 nm are prepared by a solution method. Possessing an extinction coefficient of 11.5 L g(-1) cm(-1) at 808 nm, the ultrathin Bi2 Se3 nanosheets boast a high photothermal conversion efficiency of 34.6% and excellent photoacoustic performance. After systemic administration, the Bi2 Se3 nanosheets with the proper size and surface properties accumulate passively in tumors enabling efficient photoacoustic imaging of the entire tumors to facilitate photothermal cancer therapy. In vivo biodistribution studies reveal that they are expelled from the body efficiently after 30 d. The ultrathin Bi2 Se3 nanosheets have large clinical potential as metabolizable near-infrared-triggered theranostic agents.


Subject(s)
Nanoparticles/chemistry , Phototherapy/methods , Animals , Humans , Hyperthermia, Induced , Nanostructures/chemistry , Theranostic Nanomedicine/methods
17.
Angew Chem Int Ed Engl ; 55(16): 5003-7, 2016 Apr 11.
Article in English | MEDLINE | ID: mdl-26968443

ABSTRACT

A titanium sulfonate ligand is synthesized for surface coordination of black phosphorus (BP). In contrast to serious degradation observed from the bare BP, the BP after surface coordination exhibits excellent stability during dispersion in water and exposure to air for a long period of time, thereby significantly extending the lifetime and spurring broader application of BP.

18.
Sci Rep ; 6: 21799, 2016 Feb 18.
Article in English | MEDLINE | ID: mdl-26888223

ABSTRACT

The nonlinear optical property of topological insulator bismuth selenide (Bi2Se3) is found to be well-tailored through ion irradiation by intentionally introducing defects. The increase of the optical modulation depth sensitively depends on the careful selection of the irradiation condition. By implementing the ion irradiated Bi2Se3 film as an optical saturable absorber device for the Q-switched wave-guide laser, an enhanced laser performance has been obtained including narrower pulse duration and higher peak power. Our work provides a new approach of tailoring the nonlinear optical properties of materials through ion irradiation, a well-developed chip-technology, which could find wider applicability to other layered two-dimensional materials beyond topological insulators, such as graphene, MoS2, black phosphours etc.

19.
Angew Chem Int Ed Engl ; 54(39): 11526-30, 2015 Sep 21.
Article in English | MEDLINE | ID: mdl-26296530

ABSTRACT

Black phosphorus quantum dots (BPQDs) were synthesized using a liquid exfoliation method that combined probe sonication and bath sonication. With a lateral size of approximately 2.6 nm and a thickness of about 1.5 nm, the ultrasmall BPQDs exhibited an excellent NIR photothermal performance with a large extinction coefficient of 14.8 L g(-1) cm(-1) at 808 nm, a photothermal conversion efficiency of 28.4%, as well as good photostability. After PEG conjugation, the BPQDs showed enhanced stability in physiological medium, and there was no observable toxicity to different types of cells. NIR photoexcitation of the BPQDs in the presence of C6 and MCF7 cancer cells led to significant cell death, suggesting that the nanoparticles have large potential as photothermal agents.


Subject(s)
Phosphorus/chemistry , Quantum Dots , Cell Line, Tumor , Humans , Microscopy, Atomic Force , Microscopy, Electron, Transmission , Spectroscopy, Near-Infrared
20.
ACS Appl Mater Interfaces ; 7(9): 5391-9, 2015 Mar 11.
Article in English | MEDLINE | ID: mdl-25697378

ABSTRACT

We report a new paper-based surface enhanced Raman scattering (SERS) substrate platform contributed by a poly(l-lactic acid) (PLLA) nanofibrous paper adsorbed with plasmonic nanostructures, which can circumvent many challenges of the existing SERS substrates. This PLLA nanofibrous paper has three-dimensional porous structure, extremely clean surface with good hydrophobicity (contact angle is as high as 133.4°), and negligible background interference under Raman laser excitation. Due to the strong electrostatic interaction between PLLA nanofiber and cetyltrimethylammonium bromide (CTAB) molecules, the CTAB-coated gold nanorods (GNRs) are efficiently immobilized onto the fibers. Such a hydrophobic paper substrate with locally hydrophilic SERS-active area can confine analyte molecules and prevent the random spreading of molecules. The confinement leads to focusing effect and the GNRs-PLLA SERS substrate is found to be highly sensitive (0.1 nM Rhodamine 6G and malachite green) and exhibit excellent reproducibility (∼8% relative standard deviation (RSD)) and long-term stability. Furthermore, it is also cost-efficient, with simple fabrication methodology, and demonstrates high sample collection efficiency. All of these benefits ensure that this GNRs-PLLA substrate is a really perfect choice for a variety of SERS applications.


Subject(s)
Lactic Acid/chemistry , Nanofibers/chemistry , Polymers/chemistry , Rhodamines/analysis , Rosaniline Dyes/analysis , Spectrum Analysis, Raman , Cetrimonium , Cetrimonium Compounds/chemistry , Gold/chemistry , Hydrophobic and Hydrophilic Interactions , Nanofibers/ultrastructure , Nanotubes/chemistry , Paper , Polyesters , Porosity , Static Electricity
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