1.
Chem Commun (Camb)
; 56(49): 6680-6683, 2020 Jun 18.
Article
in English
| MEDLINE
| ID: mdl-32412017
ABSTRACT
A regio- and stereoselective iodolactonization of internal electron-deficient olefinic acids has been reported, which provides a straightforward access to a series of multi-functionalized seven-membered lactones containing two consecutive chiral centers. The ester substituents on the olefins played a key role in achieving high regioselectivity. This result was proved through experiments and DFT calculations.