Terahertz-driven positron acceleration assisted by ultra-intense lasers.

Generation and acceleration of energetic positrons based on laser plasma have attracted intense attention due to their potential applications in medical physics, high energy physics, astrophysics and nuclear physics. However, such compact positron sources face a series of challenges including the beam dispersion, dephasing and unstability. Here, we propose a scheme that couples the all-optical generation of electron-positron pairs and rapid acceleration of copious positrons in the terahertz (THz) field. In the scheme, nanocoulomb-scale electrons are first captured in the wakefield and accelerated to 2.5 GeV. Then these energetic electrons emit strong THz radiation when they go through an aluminum foil. Subsequently, abundant γ photons and positrons are generated during the collision of GeV electron beam and the scattering laser. Due to the strong longitudinal acceleration field and the transvers confining field of the emitted THz wave, the positrons can be efficiently accelerated to 800 MeV, with the peak beam brilliance of 2.26 × 1012s-1mm-2mrad-2eV-1. This can arouse potential research interests from PW-class laser facilities together with a GeV electron beamline.

Ultra-brilliant GeV betatronlike radiation from energetic electrons oscillating in frequency-downshifted laser pulses.

Electrons can be accelerated to GeV energies with high collimation via laser wakefield acceleration in the bubble regime and emit bright betatron radiation in a table-top size. However, the radiation brightness is usually limited to the third-generation synchrotron radiation facilities operating at similar photon energies. Using a two-stage plasma configuration, we propose a novel scheme for generating betatronlike radiation with an extremely high brilliance. In this scheme, the relativistic electrons inside the bubble injected from the first stage can catch up with the frequency-downshifted laser pulse formed in the second stage. The laser red shift originates from the phase modulation, together with the group velocity dispersion, which enables more energy to be transfered from the laser pulse to γ-photons, giving rise to ultra-brilliant betatronlike radiation. Multi-dimensional particle-in-cell simulations indicate that the radiated γ-photons have the cut-off energy of GeV and a peak brilliance of 1026 photons s-1 mm-2 mrad-2 per 0.1%BW at 1 MeV, which may have diverse applications in various fields.

Copious positron production by femto-second laser via absorption enhancement in a microstructured surface target.

Laser-driven positron production is expected to provide a non-radioactive, controllable, radiation tunable positron source in laboratories. We propose a novel approach of positron production by using a femto-second laser irradiating a microstructured surface target combined with a high-Z converter. By numerical simulations, it is shown that both the temperature and the maximum kinetic energy of electrons can be greatly enhanced by using a microstructured surface target instead of a planar target. When these energetic electrons shoot into a high Z converter, copious positrons are produced via Bethe-Heitler mechanism. With a laser (wavelength λ = 1 µm) with duration ~36 fs, intensity ~5.5 × 1020 W/cm2 and energy ~6 Joule, ~109 positrons can be obtained.

Dense relativistic electron mirrors from a Laguerre-Gaussian laser-irradiated micro-droplet.

We investigate dense relativistic electron mirror generation from a micro-droplet driven by circularly polarized Laguerre-Gaussian lasers. The surface electrons are expelled from the droplet by the laser's radial electric field and evolve into dense sheets after leaving the droplet. These electrons are trapped in the potential well of the laser's transverse ponderomotive force and are steadily accelerated to about 100 MeV by the longitudinal electric field. Particle-in-cell simulations indicate that the relativistic electron mirrors are characterized by high beam charge, narrow energy spread, and large angular momentum, which can be utilized for bright X/γ-ray emission and photon vortex formation.

Attosecond electron bunches from a nanofiber driven by Laguerre-Gaussian laser pulses.

Generation of attosecond bunches of energetic electrons offers significant potential from ultrafast physics to novel radiation sources. However, it is still a great challenge to stably produce such electron beams with lasers, since the typical subfemtosecond electron bunches from laser-plasma interactions either carry low beam charge, or propagate for only several tens of femtoseconds. Here we propose an all-optical scheme for generating dense attosecond electron bunches via the interaction of an intense Laguerre-Gaussian (LG) laser pulse with a nanofiber. The dense bunch train results from the unique field structure of a circularly polarized LG laser pulse, enabling each bunch to be phase-locked and accelerated forward with low divergence, high beam charge and large beam-angular-momentum. This paves the way for wide applications in various fields, e.g., ultrabrilliant attosecond x/γ-ray emission.

Ultra-bright γ-ray emission and dense positron production from two laser-driven colliding foils.

Matter can be transferred into energy and the opposite transformation is also possible by use of high-power lasers. A laser pulse in plasma can convert its energy into γ-rays and then e - e + pairs via the multi-photon Breit-Wheeler process. Production of dense positrons at GeV energies is very challenging since extremely high laser intensity ~1024 Wcm-2 is required. Here we propose an all-optical scheme for ultra-bright γ-ray emission and dense positron production with lasers at intensity of 1022-23 Wcm-2. By irradiating two colliding elliptically-polarized lasers onto two diamondlike carbon foils, electrons in the focal region of one foil are rapidly accelerated by the laser radiation pressure and interact with the other intense laser pulse which penetrates through the second foil due to relativistically induced foil transparency. This symmetric configuration enables efficient Compton back-scattering and results in ultra-bright γ-photon emission with brightness of ~1025 photons/s/mm2/mrad2/0.1%BW at 15 MeV and intensity of 5 × 1023 Wcm-2. Our first three-dimensional simulation with quantum-electrodynamics incorporated shows that a GeV positron beam with density of 2.5 × 1022 cm-3 and flux of 1.6 × 1010/shot is achieved. Collective effects of the pair plasma may be also triggered, offering a window on investigating laboratory astrophysics at PW laser facilities.

Ultra-bright γ-ray flashes and dense attosecond positron bunches from two counter-propagating laser pulses irradiating a micro-wire target.

We propose a novel scheme to generate ultra-bright ultra-short γ-ray flashes and high-energy-density attosecond positron bunches by using multi-dimensional particle-in-cell simulations with quantum electrodynamics effects incorporated. By irradiating a 10 PW laser pulse with an intensity of 1023 W/cm2 onto a micro-wire target, surface electrons are dragged-out of the micro-wire and are effectively accelerated to several GeV energies by the laser ponderomotive force, forming relativistic attosecond electron bunches. When these electrons interact with the probe pulse from the other side, ultra-short γ-ray flashes are emitted with an ultra-high peak brightness of 1.8 × 1024 photons s-1mm-2mrad-2 per 0.1%BW at 24 MeV. These photons propagate with a low divergence and collide with the probe pulse, triggering the Breit-Wheeler process. Dense attosecond e-e+ pair bunches are produced with the positron energy density as high as 1017 J/m3 and number of 109. Such ultra-bright ultra-short γ-ray flashes and secondary positron beams may have potential applications in fundamental physics, high-energy-density physics, applied science and laboratory astrophysics.

All-optical bright γ-ray and dense positron source by laser driven plasmas-filled cone.

An all-optical scheme for bright γ-rays and dense e-e+ pair source is proposed by irradiating a 1022 W/cm2 laser onto a near-critical-density plasmas filled Al cone. Two-dimensional (2D) QED particle-in-cell (PIC) simulations show that, a dense electron bunch is confined in the laser field due to the radiation reaction and the trapped electrons oscillate transversely, emitting bright γ-rays forward in two ways: (1) nonlinear Compton scattering due to oscillation of electrons in the laser field, and (2) Compton backwardscattering resulting from the bunch colliding with the reflected laser by the cone tip. Finally, the multi-photon Breit-Wheeler process is initiated, producing abundant e-e+ pairs with a density of ∼ 1027m-3. The scheme is further demonstrated by full 3D PIC simulations, which indicates a positron number up to 2 × 109. This compact γ-rays and e-e+ pair source may have many potential applications, such as the laboratory study of astrophysics and nuclear physics.

Virulence genes and pathogenicity of Shigella flexneri Xv isolated in Beijing / 中华流行病学杂志

<p><b>OBJECTIVE</b>To understand the biochemical characteristics, virulence genes and pathogenicity of Shigella flexneri Xv isolated in Beijing.</p><p><b>METHODS</b>61 strains of S. flexneri Xv isolated from diarrhea patients in Beijing were systematically determined through biochemical reactions and serological tests. Application of PCR technique in detection of virulence genes on ipaH, sen, virF, ial and pulsed-field gel electrophoresis (PFGE) was used to identify the related characteristics and on rat lung slices to determine its pathogenicity.</p><p><b>RESULTS</b>All of the S. flexneri Xv could ferment glucose, mannitol, melibiose and arabinose. Using serum agglutination, we found that the antigen structure was (IV: 7, 8). IpaH, sen, virF and ial that carried rates of virulence genes appeared to be 100%, 81.97%, 75.41% and 80.30%, respectively. Among 61 strains of S. flexneri Xv, the PFGE typing of Shigella bacteria could be divided into 25 belt types while the results from rat lung slices showed inflammatory change of Xv.</p><p><b>CONCLUSION</b>S. flexneri Xv was found that it carried high rate of Shigella virulence genes, exhibiting genetic polymorphism and highly invasive.</p>

Progress in research on multilocus sequence typing technique / 军事医学科学院院刊

Multilocus sequence typing (MLST) is a molecular genotyping method based on nucleotide sequencing. The procedure of this method characterizes isolates of bacterial species using the DNA sequencing of multiple housekeeping genes(usually seven). For each housekeeping gene, the different sequences present within a bacterial species are assigned as distinct alleles.For each isolate, the alleles at each of the loci define the allelic profile or sequence type (ST). MLST has the advantages of being robust (based on genetic data) and electronically portable to generate data that allow rapid and global comparisons between different laboratories. In this paper, the principle, method, data analysis, application, advantages and flaws of MLST are introduced.

[Experimental research on remote sensing spectrometer's instrument response function].

Remote sensing spectrometers were widely used in the fields such as spectral measure and trace gas supervision in atmosphere. The instrument response functions should be measured to eliminate the effect of the spectrometer. The instrument response functions of MCT detector and InSb detector in BLUKER TENSOR 37 passive FTIR spectrometer were measured in the present paper. The instrument response functions and background functions were offered with different temperature interval. The instrument response functions of MCT detector increased with temperature, but it was the reverse for InSb detector. The background functions of InSb detector increased with temperature, and the reverse for MCT detector.