ABSTRACT
Objective To establish reference values for blood pressure in cynomolgus monkeys in different ages.Methods The blood pressures and blood lipids indexes were detected in 521 cynomolgus monkeys using an American BECKMAN-CX4 automatic biochemical analyzer and a wrist electronic blood pressure monitor.Statistical tests were performed to analyze the data.Results Significant differences were found in blood pressure values of cynomolgus monkeys in different ages.Blood pressure values in the elderly group were higher than those of other groups.The morbidity of hypertension in the elderly group was higher than those of the other groups.Body mass index (BMI) in the hypertension group was higher than that of normal group in the same age.The incidence of hypertension in the elderly group with hyperlipemia was higher than that of other groups.Logistic regression analysis showed that age, BMI and hyperlipidemia in the hypertensive group were 1.435, 1.218, and 2.337 times higher than those of the normal group when predicting the risk of hypertension.Conclusions We have initially established reference values of blood pressure in cynomolgus monkeys in different ages.Age, BMI and hyperlipidemia are risk factors of spontaneous hypertension in cynomolgus monkeys, and the measurement of blood pressure may provide a basis for the screening of cynomolgus monkey model of spontaneous hypertensive and related research.
ABSTRACT
Salaciachinensis is a traditional South and Southeast Asian herb medicine and has been reported to have an antidiabetic function via α-glucosidases inhibitory activity. In this study, the effects of S. chinensis extract (SCE) on reproductive functions of F0 males and females and the effects on survival and growth of F1 offspring were examined using Sprague-Dawley rats. SCE was administered at dose levels of 0, 500, 1000 and 2000 mg/kg/day orally to groups consisting of 25 males and 25 females. Males were dosed once a day in the morning from 8 weeks before mating, throughout the mating period and until the day before necropsy and females were dosed once a day in the morning for 2 weeks before mating and through the mating, gestation and lactation periods (until day 20 of lactation). In all SCE treatment groups, no toxic signs were noted on reproductive outcome such as estrous cycle of F0 females or any parameters for reproductive function or survival, growth, sensory reflex or function development of F1 pups. Therefore, we concluded that SCE has no effects on the reproductive outcome even at a remarkably high dosage level, 2000 mg/kg/day, in Sprague-Dawley rats.
