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2.
Article in Russian | MEDLINE | ID: mdl-7293582

ABSTRACT

In 72 epileptic patients the bone marrow was examined in various periods of epileptic paroxysms. It was found that the morphological composition of the medullary hemopoiesis was characterized by a myeloid reaction and a lowered mitotic activity of the bone marrow elements. All the shifts in the functional state of the medullary hemopoiesis correlated with the paroxysm periods and were reflected adequately in the peripheral blood picture. The states described differed sharply from the anomalous medullary hemopoiesis observed in epileptic patients having hematological complications, e.g. pernicious anemia caused by phenobarbital, hexamidine and diphenin.


Subject(s)
Anticonvulsants/adverse effects , Bone Marrow Diseases/chemically induced , Bone Marrow/pathology , Epilepsy/pathology , Hematopoiesis , Adult , Anemia/pathology , Biopsy , Bone Marrow Diseases/pathology , Female , Humans , Male , Middle Aged , Mitosis , Status Epilepticus/pathology
5.
Article in Russian | MEDLINE | ID: mdl-314714

ABSTRACT

A study of plasmocellular reactions of the bone marrow in alcoholism and alcoholic psychoses demonstrated an increase in the amount of plasmatic cells, a prevalence of mature plasmatic elements with distinctly marked basophilia and a reaction of clasmatosis. These facts indicate the functional preservation in alcoholism of the system of B cells, the derivatives of which are plasmatical elements; of an increase in the protein synthesis (including antibodies) as well as a prevalence of the so-called productive phase of immunogenesis over the adaptive.


Subject(s)
Alcoholism/immunology , B-Lymphocytes/immunology , Bone Marrow/immunology , Plasma Cells , Adult , Aged , Alcohol Withdrawal Delirium/immunology , Alcoholism/pathology , Bone Marrow/pathology , Cell Count , Humans , Male , Middle Aged , Psychoses, Alcoholic/immunology , Wernicke Encephalopathy/immunology
7.
Article in Russian | MEDLINE | ID: mdl-442902

ABSTRACT

Blood neutrophils were studied in epileptic patients. Differentiation of neutropenia induced by epilepsy from neutropenia due to anticonvulsants enabled one to reveal that incidence of the latter amounts to 6%. Differentiation of drug-induced neutropenia (54 observations) depending on the pathogenetic mechanism or origin (tonic and allergic), features of the blood picture and the nature of the disease course (stable, recurrent, transitory) is of special importance for diagnosis and choice of therapeutic tactics.


Subject(s)
Agranulocytosis/etiology , Anticonvulsants/adverse effects , Epilepsy/complications , Neutropenia/etiology , Adolescent , Adult , Anticonvulsants/therapeutic use , Carbamazepine/adverse effects , Drug Therapy, Combination , Ethosuximide/adverse effects , Female , Humans , Leukopenia/chemically induced , Male , Middle Aged , Phenobarbital/adverse effects , Primidone/adverse effects
11.
Mol Biol (Mosk) ; 10(2): 664-9, 1976.
Article in Russian | MEDLINE | ID: mdl-1053049

ABSTRACT

The rate of DNA synthesis in cells precursors of the bone marrow of 15 psychic patients was studied by tritiated thymidine autoradiography during different periods of whole alimentary starvation (duration 28 days) which was used with the aim of therapy. It was shown that starvation induced rapid, "leap", "uneven" block of DNA synthesis and decrease in mitotic index. It was found that DNA synthesis block was marked with different degree in different marrow cells. It was supposed that DNA synthesis block occured mainly during G1--S period of interphase. During the initial period of refeeding, intensification of DNA synthesis, which preceded to sharp increase in mitotic index, was observed.


Subject(s)
Bone Marrow/metabolism , DNA Replication , DNA/biosynthesis , Psychotic Disorders/metabolism , Starvation , Bone Marrow/pathology , Humans , Interphase , Mitotic Index
12.
Genetika ; 12(3): 169-72, 1976.
Article in Russian | MEDLINE | ID: mdl-955408

ABSTRACT

Dermatoglyphic alterations in schizophrenic patients are considered in virtue of literature data and the author's own investigations. The absence of obvious and regular difference between healthy people and schizophrenic patients in the incidence of finger and palm patterns is revealed. Only statistically insignificant tendency of different manifestations of some features in patients and healthy persons is observed. Skin patterns doubtly may be used as additional diagnostic paraclinical method and applied to work out genetic aspects of schizophrenia. The addiitonal investigations and particularly and the investigations of "family forms" of schizophrenia are suggested for suggested for complete solution of this problem.


Subject(s)
Dermatoglyphics , Schizophrenia/genetics , Adolescent , Adult , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Schizophrenia/diagnosis
13.
Genetika ; 11(6): 77-82, 1975.
Article in Russian | MEDLINE | ID: mdl-1218719

ABSTRACT

Mutagenic activity of 33 psychotropic drugs was studied in Drosophila metanogaster according to the CLB method. The drugs are the following: leponex, neuleptil, randolectil, teralen, chlorprotixen, TPS-23, navane, pimosid, difenisid, rudotel, eunoktin, radedorm, meprobamat, trioxasin, elenium, napoton, aponal, lorasepam, nuredal, oxyphenonat, safrasin, surmantil, amitriptilin, prothioden, melipramin, saroten, tegretol, phenobarbital, diakarb, benzonal, suksilep, morpholep, sydnocarb. The increase in the mutation rate was induced by leponex (1.37% in adults and 1.21% in larvae), difenisid (1.18% in adults), two forms of the same drug eunoktin and radedorm (about 1.6% in adults), safrasin (1.06% in imago), saroten (1,36% in imago), phenobarbital (2.02% in imago). Even a slight increase of mutagenicity of widely spread psychotropic drugs is a very serious factor which needs further investigation and specification in other models and organisms.


Subject(s)
Psychotropic Drugs/toxicity , Animals
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