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14.
Article in Russian | MEDLINE | ID: mdl-7234243

ABSTRACT

A total of 104 children aged 4 months to 13 years with meningococcal infection were examined. For control 600 healthy donors were used. Histocompatibility antigens were determined by the lymphotoxic test. Altogether 36 antigens of the loci, A, B and C were determined. The data thus obtained indicate that the risk of contacting the infection is 6 times greater for persons with Hl A-Bw16 phenotype and 3 times greater for persons with HL A-A12 phenotype than for persons with Hl A-A1 phenotype.


Subject(s)
HLA Antigens/analysis , Meningococcal Infections/genetics , Nasopharyngitis/genetics , Pharyngitis/genetics , Adolescent , Child , Child, Preschool , Humans , Infant , Meningitis, Meningococcal/genetics , Phenotype , Risk , Sepsis/genetics
18.
Article in Russian | MEDLINE | ID: mdl-220822

ABSTRACT

The level of cyclic 3,5-adenosine monophosphate (cAMP), the activity of adenylate cyclase (AC) and phosphodiesterase (PDE) were studied in bioptates of the muscles of 17 patients with different forms of myopathy. The cAMP level and AC activity were decreased while that of PDE was increased. These changes are particularly demonstrative in patients with Erba type of myopathy. It is recommended that beta-adrenomimetic drugs and PDE inhibitors may be tried in pathogenetic therapy.


Subject(s)
Cyclic AMP/analysis , Muscles/analysis , Muscular Dystrophies/metabolism , 3',5'-Cyclic-AMP Phosphodiesterases/metabolism , Adenylyl Cyclases/metabolism , Adult , Female , Histocytochemistry , Humans , Male , Middle Aged , Muscles/enzymology , Muscular Dystrophies/drug therapy , Muscular Dystrophies/enzymology , Sympathomimetics/therapeutic use , Syndrome
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