ABSTRACT
The retrospective research included 1983 patients with different abdominal surgical pathology. Parameters of homeostasis were estimated in preoperative period and early postoperative period. Frequency of occurrence and relevance of different clinical risk factors of thrombosis were analyzed. The rate of development of thromboembolic complications was investigated in studied subgroup of patients. It was revealed, that high risk groups of thrombosis progress were the patients with malignant disease of the pancreas, the esophagus, the large and straight intestine as well as obstructive jaundice of malignant genesis. The most significant clinical factors were the presence of malignant process, accompanied by cardiac pathology, dehydration and high number (3 and more) on ASA scale.
Subject(s)
Abdomen , Postoperative Complications , Surgical Procedures, Operative , Thromboembolism , Abdomen/physiopathology , Abdomen/surgery , Aged , Female , Hemostasis , Humans , Male , Middle Aged , Postoperative Care/methods , Postoperative Complications/blood , Postoperative Complications/prevention & control , Preoperative Care/methods , Retrospective Studies , Risk Assessment , Risk Factors , Surgical Procedures, Operative/adverse effects , Surgical Procedures, Operative/methods , Thromboembolism/blood , Thromboembolism/etiology , Thromboembolism/prevention & controlABSTRACT
24,564 autopsy protocols from the central city hospital and oncology dispensary were analyzed in order to evaluate the rate and dynamics of postoperative thrombotic complications (PTC). The PTC rate was 14.89% and went up two-fold within the recent 20 years. The rate of pulmonary thromboembolism (PTE) was 10.13%; it increased during the recent 20 years from 6.75% to 17.30%. No significant difference was registered between the PTE rates in oncology and other patients (16.01% and 14.10%, respectively). Pelvic vein thrombosis was defined as a source of PTE in 50.11% of cases; deep vein thrombosis was found only in 28.54% of cases. The rate of the in-life PTE diagnosis was 42.8%. Despite refinements and standardization related with the use of anticoagulants, prevention and PTC management, the discussed phenomenon still remains a crucial issue for practitioners.
Subject(s)
Postoperative Complications , Thromboembolism/etiology , Venous Thrombosis/etiology , Female , Humans , Male , Statistics as Topic , Thromboembolism/epidemiology , Venous Thrombosis/epidemiologyABSTRACT
Loss of heterozygosity (LOH) on the long arm of human chromosome 16 is a common genetic alteration observed in both invasive ductal and invasive lobular breast carcinomas. We have generated a high-resolution integrated map encompassing the smallest region of LOH overlap within chromosome 16q22.1 (SRO2). Southern hybridization experiments using more than 140 probes resulted in the assembly of 152 bacterial large-insert clones into a 2.8-Mb contig covering SRO2. The structure of the contig was verified by long-range mapping using total human genomic DNA, and the contig orientation was determined by fluorescence in situ hybridization. A total of 68 transcripts have been identified in the map. One of the genes residing within SRO2 is the E-cadherin gene, CDH1, which has previously been shown to be mutated in lobular breast carcinomas, resulting in loss of E-cadherin expression. In most cases of ductal carcinoma, which is the major mammary cancer type, E-cadherin is normally expressed, suggesting that other genes within 16q22.1 are involved in the development of this tumor subtype. The high-resolution map presented in this study provides a valuable resource for identification of tumor suppressor genes expected to be involved in the etiology of breast carcinomas.
