[Chronobiological aspects of gerontology].

The hypothesis of the dynamics of aging on the chronobiological grounds is presented. The results of the original research are demonstrated as well as the conclusions made by the leading authorities in the human individual annual and perennial endogenous cycles are treated. Risk-zones, which tend to increase the possibility of "mistakes" in a genetic program that lead to aging of organism are proposed. The data obtained could provide an opinion of existing both the perennial and annual endogenous cycles, that begin from the moment of conception and include nine months of the embryo period and three months after the date of birth. The data available provide a ground for a hypothesis verifying the trimester time-genetic program of the endogenous year. The "mistakes" in the chronobiological program emerging as the reaction on the environment during the periods of intensive growth of metabolic process are supposed to be one of the essential causes of aging and early death.

[Epidemiological effectiveness of an inactivated three-component flu vaccine with an increased concentration of hemagglutinin in the inoculation dose]. / Epidemiologicheskia éffektivnost' inaktivirovannoi trekhkomponentnoigrippoznoi vaktsiny s povyshennoi kontsentratsiei gemaggliutinina v privivochnoi doze.

The work presents the results of the evaluation of mass immunization of working adults with inactivated trivalent influenza vaccine under the conditions of an epidemic caused by influenza viruses A (H1N1), A (H3N2) and B. This immunization produced no effect on influenza morbidity in the groups of vaccinees in comparison with those of nonvaccinated persons. The index of effectiveness was 1.0 and less. The ineffectiveness of mass immunization was due to a high level of natural immunity to influenza and the extensive use of influenza vaccine in past years.