[The effect of the preparation Wobe-Mugos E on the functional and biochemical status of the kidneys in the polyuric stage of sublimate-induced nephropathy]. / Vplyv preparatu Wobe-Mugos E na funktsional'nyi ta biokhimichnyi stan nyrok u poliurychnu stadiiu sulemovoï nefropatiï.

The protective effect of Wobe-Mugos appliance on the kidney function and biochemical state in polyuric stage of sublimate nephropathia at the moment of tubulointerstitial component formation was revealed in experiments on 40 white male rats. It appeared in the increase of hydrogenous ion excretion, titred acids, renal tissue fibrinolytic and proteolytic activity. The succinatdehydrogenase activation in renal cortex matter pointed out on the improvement of energy balance.

[Interrelation between levels of eicosanoids and tachykinins in the expired air condencate in the obstructive type respiratory insufficiency in patients with destructive pulmonary tuberculosis]. / Vzaiemozv'iazok mizh rivnem eikozanoïdiv i takhikininiv u kondensati vydykhuvanoho povitria pry obstruktyvnomu typi dykhal'noï nedostatnosti u khvorykh na destruktyvnyi tuberkul'oz lehen'.

The content was studied of vasoactive intestinal peptide (VIP), substantia P (SP), bombesine (BMB), prostaglandins (PG) E2, F2alpha, 6-keto-F1alpha, Tx A2, and leukotrien (LT) B4 in the expired air condensate with the aid of the radioimmune technique to reveal a relation between pulmonary tachykinins and eicosanoids in obstructive type respiratory incompetence in patients with pulmonary tuberculosis. In patients with pulmonary tuberculosis, a high level of BMB was measurable in the expired air condensate. A linear negative correlation has been established between BMB content and forced expiratory volume, SP and respiratory volume, SP and lung capacity. In pulmonary tuberculosis, PGE2 and PGF2alpha levels are significantly evaluated. There was a positive correlation between BMB content and PGF2a in the expired air condensate, which fact suggests their synergic action on the smooth muscles of the bronchi and bronchioles.

[Experimental pharmacodynamic study of rifampicin administered by various methods]. / Eksperimental'noe izuchenie farmakokinetiki rifampitsina pri razlichnykh metodakh vvedeniia.

The experimental study was performed on 80 male albino rats. The dose of rifampicin was 10 mg per 1 kg of the body weight. The highest rifampicin levels in the lung tissue were determined at all periods after intrabronchial administration of the drug. Thus, 2 hours after intrabronchial instillation of rifampicin its level in the lung tissue was 10--12 times higher than that after its enteral use. In 4 hours the antibiotic level decreased. Still, it remained 10 times higher than that after the enteral use. In 8 hours the level of rifampicin administered intrabronchially was almost the same as its maximum concentration in the lung tissue attained after the enteral use in 2 hours. By the 12th hour of the intrabronchial administration of rifampicin its concentration in the lung tissue markedly decreased. Still, it was 5--6 times higher than that after the enteral use. The rifampicin levels in the liver tissue after intrabronchial administration of the drug were at all periods much lower than those after the enteral use. The levels of rifampicin in the blood serum after its intrabronchial and enteral administration, as well as those in the liver tissue did not significantly differ.