ABSTRACT
Apesar da atividade farmacológica de Mikania glomerata Spreng. ser conhecida desde longa data, existem poucos estudos visando a preparação de produtos padronizados que garantam uma produção uniforme, doses eficazes e estabilidade. Nesse trabalho, foram realizados ensaios objetivando a otimização do processo extrativo; tratamento da droga vegetal para o preparo de tinturas; determinação da melhor forma de estocagem e otimização da preparação da forma farmacêutica (xarope).
Although the pharmacological activity of Mikania glomerata Spreng. has been well known for a long time, there are a few studies concerning the elaboration of phytopharmaceutical products that assure an uniform preparation, effective doses and stability. In this work, tests with the objective of the optimization of the extraction process were performed; treatment of the plant drug for preparation of tinctures; determination of the adequate form of storage and the optimization of the preparation of the pharmaceutical form (syrup).
ABSTRACT
Maytenus ilicifolia, (conocida como congorosa en español y espinheira-santa en portugués), es un arbusto silvestre que crece en países Sudamericanos, principalmente en el Sur de Brasil (Mata Atlántica), Este de Argentina, Centro y Este de Uruguay y Sur de Paraguay. Famosa entre los aborígenes de principios del siglo XIX como planta anticancerígena, hoy día la hoja de congorosa (Mayteni folium) es una droga utilizada para tratar problemas digestivos en forma de infusión. En Brasil constituye fitofármaco indicado principalmente en el tratamiento de la ulcera gástrica. Al respecto, numerosas investigaciones han demostrado las propiedades antiulcerogénicas, las cuales parecen estar relacionadas con la presencia de dos clases de compuestos: fenoles y triterpenos. Recientemente, la hoja de M. ilicifolia ha sido incorporada en Atención Primaria de Salud, tanto en Argentina como en el Brasil
Maytenus ilicifolia, (know as congorosa in Spanish and espinheira-santa in Portuguese) is a wild shrub that grows in South American countries, especially in South Brazil (Mata Atlántica), eastern Argentine, eastern and centre of Uruguay and South of Paraguay. Used by the indigenous people as anticancer plant in the beginning of XIX century, nowadays the leaves of M. ilicifolia (Mayteni folium) is employed as tea for the treatment of digestive aliments for stomach and ulcer illness treatment. In Brazil there is it is a phytomedicine indicated mainly for gastric ulcers. Several researches have demonstrated the antiulcerogenic properties, which seems to be closely related to the presence of two classes of substances: phenols and triterpenes. Recently, M. ilicifolia was incorporated in primary health care in Brazil as well as in Argentine
Subject(s)
Humans , Maytenus/chemistry , Anti-Ulcer Agents/therapeutic use , Plants, Medicinal , Beverages , Plant Leaves/chemistry , Stomach Ulcer/drug therapy , Argentina , BrazilABSTRACT
Medicinal plants still account for 25 per cent of medical prescriptions in developed countries and for more than 80 per cent in developing countries. Vegetable raw materials available in the commercial market frequently do not comply with the requirements of constant activity, efficacy and quality. There is a need for more strict specifications of vegetable drugs and the pharmacopoeial prescriptions usually provide these specifications. The characteristics of pharmacopoeial prescriptions are discussed in view of most common problems in drug qaulity.
