[Characteristics of the lipid transport system in psoriasis]. / Osobennosti lipid-transportnoi sistemy pri psoriaze.

Cholesterol of high density lipoprotein (HDL) subfractions (HDL2 and HDL3), activity of cholesterol ester transport protein (CETP), and standard lipoprotein parameters (cholesterol, triglycerides, HDL cholesterol) were measured in plasma of 192 patients with various psoriasis forms, which included simple "distributed psoriasis", erythrodermic and arthropathic psoriasis. Among psoriatic patients unusually high percent of persons with both hypo- and hyper-cholesterolemia was observed. The same situation was observed with frequency of cases with both low and high plasma HDL cholesterol levels, the distribution being depending from disease severity. In contrast to norm, psoriasis patients had big range not only in HDL2 cholesterol level, but also in HDL3 cholesterol. They also had decreased CETP activity. Data obtained suggest the existence of changes in reverse cholesterol transport system in psoriasis, which may influence skin cell proliferation (via control of cell supply with cholesterol).

[Features of distribution of free and esterified cholesterol in the epidermis, biological membranes and plasma lipoproteins in psoriasis]. / Osobennosti raspredeleniia svobodnogo i éterifitsirovannogo kholesterina v épidermise, biomembranakh i lipoproteidakh plazmy pri psoriaze.

The parameters of cholesterol (CS) metabolism in the epidermis, blood plasma lipoproteins, and red cell membranes were assessed in patients with psoriasis. The levels of free and total CS in extracts from the surface of epidermis, in plasma lipoproteins, and in plasma triglycerides were measured, and the molar ratio CS/ phospholipids (CS/PL index) in red cell membranes assessed in 194 patients with psoriasis of different severity. The levels of free and total CS in the epidermis were found to increase as the psoriatic process grew in severity. These shifts manifested even in apparently intact skin sites, which indicated the primary nature of total-system disorders. As for the plasma lipids, statistically reliable changes were observed only for the relative level of free cholesterol of the plasma and, most of all, high-density lipoproteins. These values for the mean parameters in the five groups of examinees correlated (r from 0.71 to 0.92) with the levels of total and free CS in the epidermis. Contrary to it, the levels of total CS and triglycerides in the plasma had a tendency to decrease as the severity of the psoriatic process augmented. Such a trend was statistically reliable for the CS/PL index, which increased in all the patients except the most grave, this increase being the more, the less grave the disease was; this was manifested in an inverse correlation (r = 0.9, on average) with the epidermal CS. The detected uncommon relationship between CS values in the epidermis, plasma lipoproteins, and biological membranes indicates heretofore unknown features of metabolic disorders in psoriasis.

[Free and esterified epidermal cholesterol in psoriasis]. / Svobodnyi i éterifitsirovannyi kholesterin épidermisa pri psoriaze.

The levels of epidermal total, free and esterified cholesterol were studied in psoriatic patients. Lipids were isolated from the areas of psoriatic lesions and from the normally appearing epidermis by the authors' non-invasive surface extractive method. The quantity of cholesterol was given in microgram per square centimeter. Fifty six and 11 healthy persons were examined. The skin cholesterol levels were twice-four-fold higher in the patients than in the healthy subjects. The same levels were noted from the areas of lesion and from normally appearing epidermis. The proportion of an esterified fraction decreased mainly in the normally appearing epidermis areas, especially in severe psoriasis. The role of the findings was also discussed.

[A method of determination of cholesterol contents on the surface of the human skin and prospects of its use. II. Psoriasis]. / Metod opredeleniia soderzhaniia kholesterina na poverkhnosti kozhi cheloveka i perspektivy ego ispol'zovaniia. 2. Psoriaz.

A noninvasive method for cholesterol extraction from the surface layers of the epidermis is suggested. Levels of cholesterol and its fractions were measured in extracts obtained from the foci of psoriasis and apparently intact skin of 105 patients with psoriasis. Cholesterol levels were found noticeably increased, mainly at the expense of its free fraction in involved foci and in apparently intact skin. A conclusion is made on the good informative value of the suggested method.

[The treatment of psoriasis by efferent methods on an outpatient basis]. / Lechenie psoriaza éfferentnymi metodami v ambulatornykh usloviiakh.

In addition to conventional outpatient treatment 165 psoriasis patients underwent hemosorption (100 cases) or plasmapheresis (65 cases). The efferent methods used proved beneficial in 99 (60%) of the patients that got to have normal hemograms, reduced CIC and middle molecular weight peptides levels in blood. The response depended on the disease duration irrespectively of the method of efferent treatment. The remission (1-2 years) was achieved in 79 (48%) of the patients treated who developed neither side effects no complications. Compared to controls on hospital routine therapy, a mean decrease in treatment duration made 10 +/- 4 days. Efferent outpatient treatment of psoriasis is recommended for patients with torpid course of the disease and for those who is ill not longer than 5 years.

[Enterosorption in the combined therapy of psoriasis patients]. / Enterosorbtsiia v kompleksnoi terapii bol'nykh psoriazom.

The authors consider the clinical efficacy of enterosorption, carried out in 112 patients with various forms of psoriasis. Indications for and contraindications to this treatment modality are defined. Changes in the level of endogenous intoxication in the paramecium test over the course of enterosorption treatment are analyzed.