[Some indices of trace elements and antioxidant status in rats under chromic intoxication].

There was investigated the effect of chronic Cr (VI) on the content of chromium, iron, copper; zinc, nickel in the blood of rats and activity of antioxidant enzymes of erythrocytes in Wistar rats. The chromium concentration has been shown to increase multifold while the level of other metal is more or less declining. Also it was found a decrease in the activity of such antioxidant enzymes as superoxide dismutase, catalase, and the activation of the processes of free radical oxidation. Thus, it can be assumed that the effect of Cr (VI) is implemented via an imbalance of trace elements and the activation of the processes of free radical oxidation.

[Restoration of the blood rheological patients with cap on the background of arterial hypertension in the process of hospital treatment].

The parameters of blood rheology at constant and varying shear rates in 30 patients with community-acquired pneumonia on a background of hypertension and 30 patients with community-acquired pneumonia during treatment. When recovery of rheological properties of blood disorders are in 39-81% of patients.

[Monitoring the quality of drinking water and air in the industrial center].

The quality of potable water at the exit point for distribution networks and a network for three zones (central, east and northern) where the Orenburg population lived compactly were studied which showed its difference. The complex anthropogenic and total oxidative loads created by aqueous and air environments were calculated; the maximum values for inhabitants of the east part of the city were established, which correspond to the higher levels of nitrates, chlorides, and sulfates in the water and its general mineralization and general rigidity.

[Association between the levels of metals and the intensity of oxidative stress in the body].

The hair levels of metals were measured in the workers of gas-and-chemical industry. The intensity of oxidative stress was estimated from the activity of antioxidative enzymes in the lysates of erythrocytes and serum gamma-glutamyltransferase. An association was found between the content of the metals under study and the intensity of free radical oxidation processes in persons engaged in different production cycles.

[Prevalence of hypercholesterolemia in the Orenburg Region].

The environmental oxidative burden was established in the eastern, central, and western areas of the Orenburg Region. The rate of serum lipid peroxidation (LPO) processes was determined. The level of cholesterol and its distribution by the fractions of lipoproteins of different classes were studied in the region's residents. The residential areas with a high oxidative load are characterized by the higher rate of LPO and the prevalence of hypercholesterolemia.

[The chemical and trace element composition of water sources in the Orenburg Region].

The chemical composition of drinking water was studied by some indices: total mineralization, oxidability, harshness by different regional economic areas of an angoindustrial region. The content of trace elements, imbalance of which had been found by earlier studies, was determined. Higher water mineralization was ascertained in the central area, higher water harshness and oxidability were in the eastern area. The areas under study showed the inhomogeneous content of trace elements.

[Impact of oxidative stress on the prevalence of hypercholesterolemia under the conditions of an industrial town].

The level of cholesterol and its distribution by the fractions of lipoproteins of different classes were studied in the dwellers of an industrial town. The persons living in the residential areas characterized by a high oxidative stress were observed to have higher blood cholesterol levels and dyslipoproteinemia.

[Free radical oxidation in the assessment of health risk].

Aliovalent metals (d-metals, such as manganese, nickel, iron, copper, chromium, etc.) which are able to change the degree of oxidation, to activate free radical oxidative processes, and to initiate the development of the condition that is currently defined as oxidative stress soundly and which are diagnostic criteria in the prenosological assessment of health risks are prominent among other priority ambient air pollutants. The findings suggest that there is a direct relationship between the calculated indices characterizing the carcinogenic and noncarcinogenic effects, the risk of oxidative stress, the environmental availability of prooxidants, mainly d-elements (manganese, nickel, copper, zinc) and the actual values of an increase in the rate of lipid peroxidation, of a decrease in antioxidative activity, and of an elevation in the level of methemoglobin formation.