Actively Q switched radially polarized Ho:YAG laser with an intra-cavity laser-written S-waveplate.

Nanosecond Q switched pulses and radial polarization are established stand-alone techniques for enhanced laser materials processing applications, but are generally challenging to achieve simultaneously at high average power levels. Here, we demonstrate a 20.6 W radially polarized Ho:YAG rod laser which has been actively Q switched in order to generate 515 µJ, 210 ns pulses at 2097 nm. By utilizing an ultra-low-loss spatially variant birefringent wave plate (S-waveplate) inside the laser cavity, the linearly polarized fundamental mode has been converted to a radially polarized donut-shaped beam with very high conversion efficiency.

Nested-ring doping for highly efficient 1907 nm short-wavelength cladding-pumped thulium fiber lasers.

Cladding-pumped Tm-doped fiber lasers operating below 1950 nm have difficulty matching the high-efficiency, power-scalable output that can be achieved at longer wavelengths. This challenge arises due to the strong three-level behavior at short wavelengths and strong competition from higher-gain long wavelength emission. In this Letter, we demonstrate a nested-ring fiber design in which a highly doped Tm ring is embedded within a larger undoped core. The fiber is specifically tailored for highly efficient and high power short-wavelength operation (<1950nm). The nested-ring Tm fiber laser has generated 62 W of single-mode 1907 nm output with up to 65% (70%) slope efficiency with respect to launched (absorbed) pump power.

Controllable duration and repetition-rate picosecond pulses from a high-average-power OP-GaAs OPO.

We report an orientation-patterned gallium arsenide (OP-GaAs) optical parametric oscillator (OPO) offering a high degree of temporal flexibility with controllable pulse repetition rates from 100 MHz to 1 GHz and pulse durations from ∼95 ps to ∼1.1 ns. The maximum average power of 9.2-W signal (3.3 µm) and 4.5-W idler (4.9 µm) was obtained at a repetition rate of 100 MHz and a pulse duration of ∼95 ps, with a pump power of 34.3 W and at a slope efficiency of 45.4%. The corresponding total average output power of 13.7 W is the highest power achieved to date from an OP-GaAs OPO, to the best of our knowledge.

High-average-power picosecond mid-infrared OP-GaAs OPO.

We report a high-average-power mid-infrared picosecond (ps) optical parametric oscillator (OPO) based on orientation-patterned gallium arsenide (OP-GaAs), with wide wavelength tunability. The OP-GaAs OPO is synchronously pumped by a thulium-doped-fiber (TDF) master oscillator power amplifier (MOPA), seeded by a gain-switched laser diode. At a pump power of 35.3 W and a repetition rate of 100 MHz, a maximum OPO total average output power of 9.7 W (signal 5.7 W (0.60 kW peak power), idler 4.0 W (0.42 kW peak power)) is obtained at signal and idler wavelengths of 3093 nm and 5598 nm, and a thermally induced power roll-off is observed. To mitigate the thermal effects, an optical chopper is placed before the OPO to provide burst mode operation and a reduced thermal load. We achieved a linear growth in OPO output power over the full range of available pump powers in this instance confirming thermal effects as the origin of the roll-off observed under continuous pumping. We estimate the maximum peak powers of the signal and idler are estimated to be over 0.79 kW and 0.58 kW, respectively in this instance. A wide mid-infrared wavelength tuning range of 2895-3342 nm (signal) and 4935-6389 nm (idler) is demonstrated.

47 W continuous-wave 1726 nm thulium fiber laser core-pumped by an erbium fiber laser.

The high-power, short-wavelength operation of a thulium-doped silica fiber laser at 1726 nm has been demonstrated in a core-pumped monolithic (all-fiber) resonator configuration, in-band pumped by a high-power erbium-only fiber laser operating at 1580 nm. The thulium fiber laser yielded 47 W in a single-spatial-mode output beam for 60-W absorbed pump power. The corresponding slope efficiency, with respect to an absorbed pump power of 80%, compares favorably with the theoretical maximum (Stokes) efficiency of 91.5%. The prospects for further scaling of single-mode power in this wavelength regime to >100 W are considered, as well as the potential applications for high-power lasers operating in this difficult-to-reach wavelength band.

Tunable holmium-doped fiber laser with multiwatt operation from 2025 nm to 2200 nm.

The emission band of holmium-doped silica fibers extends beyond 2200 nm, which means these lasers have the potential of covering considerable parts of the atmospheric transmission window between ∼2100 nm and 2250 nm. However, efficient operation toward 2200 nm is challenging due to absorption in fused silica at the laser wavelength. Here we present a holmium-doped fiber laser specifically targeting long-wavelength operation. The laser is implemented as a high-feedback wavelength selective ring cavity and is tunable from 2025 nm to 2200 nm. A maximum slope efficiency of 58% is obtained at 2050 nm and a slope of 27% is obtained at 2200 nm. A power of 5.5 W from a single aperture (8.9 W total) is demonstrated at 2200 nm. Our results represent extended coverage of the 2 µm spectral band with multiwatt-level silica fiber lasers.

High gain holmium-doped fibre amplifiers.

We investigate the operation of holmium-doped fibre amplifiers (HDFAs) in the 2.1 µm spectral region. For the first time we demonstrate a diode-pumped HDFA. This amplifier provides a peak gain of 25 dB at 2040 nm with a 15 dB gain window spanning the wavelength range 2030 - 2100 nm with an external noise figure (NF) of 4-6 dB. We also compare the operation of HDFAs when pumped at 1950 nm and 2008 nm. The 1950 nm pumped HDFA provides 41 dB peak gain at 2060 nm with 15 dB of gain spanning the wavelength range 2050 - 2120 nm and an external NF of 7-10 dB. By pumping at the longer wavelength of 2008 nm the gain bandwidth of the amplifier is shifted to longer wavelengths and using this architecture a HDFA was demonstrated with a peak gain of 39 dB at 2090 nm and 15 dB of gain spanning the wavelength range 2050 - 2150 nm. The external NF over this wavelength range was 8-14 dB.

Metabolism and disposition of fluticasone furoate, an enhanced-affinity glucocorticoid, in humans.

The purpose of this study was to investigate the metabolism and disposition of fluticasone furoate, an enhanced-affinity glucocorticoid receptor agonist, in humans. In a two-part, open-label design study, five healthy male subjects received a p.o. dose of 2 mg of [(14)C]fluticasone furoate, followed 4 weeks later by an i.v. dose of 0.25 mg of [(14)C]fluticasone furoate (as a 30-min infusion). Oral absorption was rapid and estimated at approximately 30%, although the oral bioavailability was markedly lower at 1.6%, limited by extensive first-pass metabolism. Plasma clearance was 58.3 l/h, with a volume of distribution of 642 liters and a terminal elimination half-life of 15.3 h. The major circulating component identified in plasma extracts after i.v. and p.o. dosing was unchanged parent compound, with 17beta-carboxylic acid (GW694301X; M10) also being notable after p.o. administration. Mean recovery of radioactivity was approximately 92 and 102% at 216 and 168 h after i.v. and p.o. administration, respectively, with most (at least 90%) recovered in the feces. Fluticasone furoate was extensively metabolized, with only trace amounts of unchanged parent compound observed in feces following either route of administration. The predominant pathway was removal of the S-fluoromethyl carbothioate group to yield GW694301X (M10). Other pathways included oxidative defluorination to yield a hydroxyl at the C6 position. There was no evidence for metabolic loss of the furoate group from fluticasone furoate or any of its metabolites. Evidence presented suggests that enterocytes have a role in the metabolism of unabsorbed fluticasone furoate.