[Multiyear and seasonal hepatitis A morbidity in different population age groups in certain areas]. / Mnogoletniaia i sezonnaia zabolevaemost' gepatitom A razlichnykh vozrastnykh grupp naseleniia na nekotorykh territoriiakh.

At the areas with high activity of hepatitis A (HA) epidemic process the duration of epidemic cycles was shown to differ, the intervals between the peaks of morbidity increasing in older age groups. The beginning of seasonal rises exceeding the average annual HA morbidity level in different age groups was found to depend on the activity of the epidemic process. At the areas with the highest activity of the epidemic process children aged 1-2 years were the first to be affected by the seasonal rise of HA. Stable direct correlation between HA morbidity levels at the beginning of seasonal rises and some markers indicative of unfavorable sanitary conditions (the size of the fly population, the purity of water samples deviating from the requirement of the Government Standard) during the preceding year was demonstrated.

[Characteristics of the formation of the HBsAg carrier state among pregnant women and newborn infants and their role in the spread of hepatitis B]. / Osobennosti formirovaniia nositel'stva HBsAg sredi beremennykh i novorozhdennykh i ikh rol' v rasprostranenii gepatitia B.

The authors analyze the incidence rate of HBsAg carriership among 8, 120 pregnant women and 261 newborn infants at different periods after birth. The levels of HBsAg carriership among pregnant women and the members of their families, as well as among the personnel of maternity clinics and blood donors, have been established. The rate and time of the detection of HBsAg in infants born to mothers found to be HBsAg carriers have been determined. Measures for the prophylaxis of hepatitis B are discussed with due regard to the specific epidemiological features of the spread of HBsAg carriership, established in this study, and to the presence of antibodies to HBsAg among the above-mentioned groups of the population.

[The tick Ornithodoros papillipes count in Namangan and Andizhan Provinces and its determining factors]. / Chislennost' kleshcha Ornithodoros papillipes v Namanhanskoi i Andizhanskoi oblastiakh i faktory, ee opredeliaiushchie.

Analysis of the abundance of the tick O. papillipes in the Namangan and Andizhan districts was conducted on vast material. According to the tick abundance (from very high to very low) settlements were arranged into five groups. Most common are settlements with a high and average tick abundance. In most cases the agent of TRF was isolated from the ticks. Natural and anthropogenic factors determining the abundance rate of ticks in some settlements and possibilities of their practical use for the quick annihilation of TRF nidi are discussed.

[Comparative study of the safety, reactogenicity and antigenic activity of chemical and live brucellosis vaccines in a controlled epidemiological trial]. / Sravnitel'noe izuchenie bezvrednosti, reaktogennosti i antigennoi aktivnosti brutselleznoi khimicheskoi i zhivoi vaktsin v usloviiakh kontroliruemogo épidemiologicheskogo opyta.

The complex evaluation of the reactogenicity characteristics revealed that after immunization with chemical brucellosis vaccine systemic reactions observed in most of the vaccinees were mildly pronounced and local reactions, mildly and moderately pronounced, their duration not exceeding 48-72 hours. During 4 months after immunization the antigenic and immunogenic potency of chemical brucellosis vaccine was no different from that of live brucellosis vaccine; seropositive persons immunized with chemical and live brucellosis vaccines showed no statistically significant differences in the geometric mean of their antibody titers, as determined in a number of serological tests, for a year after immunization. The examination of the vaccinees 4 and 12 months after immunization revealed that the sensitizing activity of chemical brucellosis vaccine was, respectively, 12.2 and 2.5 times lower than the allergenic action of live brucellosis vaccine.

[Current status of the foci and morbidity of tick-borne relapsing fever in Uzbekistan]. / Sovremennoe sostoianie ochagov i zabolevaemost' kleshchevym vozvratnym tifom v Uzbekistane.

The contemporary state of settlement nidi of tick-borne relapsing fever is discussed on the material collected in the Namanganskaya and Andizhanskaya regions of Uzbek SSR. Despite the control measures and rise of the sanitary culture of population the conditions are still preserved for the maintenance of nidi. As in ancient estates, classical nidi of tick-borne relapsing fever, so in modern ones there are preserved conditions for existence of flourishing populations of vectors, i.e. favourable habitats and the availability of hosts. The analysis of factors is given affecting the contemporary level of sick-rate with tick-borne relapsing fever. Within the limits of the distribution area of the vector a higher sick-rate should be expected than it is registered.

[Determination of the optimal inoculation dose of Brucella chemical vaccine]. / Opredelenie optimal'noi privivochnoi dozy brutselleznoi khimicheskoi vaktsiny.

Brucellosis chemical vaccine, when injected intramuscularly, proved to be low-reactogenic, postvaccinal reactions, both systemic and local, becoming less frequent and intense with the decrease of the dose from 2 to 0.5 mg. The highest antigenic and immunogenic activity was observed with a dose of 1 mg; out of 4 tested doses this dose produced the highest percentage of seroconversions, the highest titers of agglutinins and the longest time of their persistence in the subjects. When introduced in doses of up to 2 mg, brucellosis chemical vaccine did not induce pronounced sensitization. A high degree of correlation between the indices of seroconversion frequency in Wright's agglutination test and Huddleson's test was established after vaccination with all tested doses. This fact indicates that one of these tests can be used for the assessment of the antigenic and immunogenic activity of the vaccine at an early period after immunization (the term of observation not exceeding 3 months). On the basis of the complex comparison of the indices characterizing the reactogenicity and the antigenic and immunogenic activity of 4 tested doses of brucellosis chemical vaccine a dose of 1 mg was chosen as the optimum vaccination dose.