Systemic Effects of Perineural Glucocorticoids on Fasting Serum Glucose, Potassium, and White Blood Cell Count in Total Hip Arthroplasty.

Purpose: Glucocorticoids are commonly used as regional anesthesia adjuvants to improve blockade quality and duration. There are limited data in the literature regarding the potential systemic effects and safety of perineural glucocorticoids. This study examines the effects of perineural glucocorticoids on serum glucose, potassium, and white blood cell count (WBC) in the immediate postoperative period after primary total hip arthroplasty (THA). Patients and Methods: A retrospective cohort study was carried out at a tertiary academic medical center utilizing electronic health records of 210 patients who underwent THA, for which patients received either a periarticular local anesthetic injection alone (PAI, N=132) or additional peripheral nerve blocks (PNB, N=78) containing 10 mg dexamethasone and 80 mg methylprednisolone acetate (PAI+PNB). The primary outcome was change in serum glucose from a preoperative baseline on postoperative days (POD) 1, 2, and 3. Secondary outcomes included changes in WBC and serum potassium. Results: The change in serum glucose from baseline was found to be significantly higher in the PAI+PNB group compared to the PAI group on POD 1 (mean difference 19.87 mg/dL, 95% CI [12.42, 27.32]; P<0.001) and POD 2 (mean difference 17.5 mg/dL, 95% CI [9.66, 25.44], P<0.001). No significant difference was found on POD 3 (mean difference -8.18 mg/dL, 95% CI [-19.07, 2.70], P=0.14). Statistically significant but clinically insignificant differences were detected in serum potassium in the PAI+PNB group compared to the PAI group on POD1 (mean difference 0.16 mEq/L, 95% CI [0.02, 0.30], P=0.03) and WBC on POD 2 (mean difference 3.18 × 1000/mm3, 95% CI [2.14, 4.22], P<0.001). Conclusion: Patients who underwent THA and received PAI+PNB with glucocorticoid adjuvants demonstrated higher elevations in serum glucose for the first two PODs compared to patients who received PAI alone. These differences resolved by a third POD and are likely to be of no clinical significance.

Transmuscular Quadratus Lumborum and Lateral Femoral Cutaneous Nerve Block in Total Hip Arthroplasty.

OBJECTIVES: Adequate pain control after total hip arthroplasty is essential for patient satisfaction and surgical outcome. METHODS: A retrospective study with before and after design was performed in 210 elective total hip arthroplasty patients. The control group (N=132) received spinal anesthesia with periarticular injection (PAI) and the treatment group (N=78) received transmuscular quadratus lumborum block and lateral femoral cutaneous nerve block in addition to spinal anesthesia and PAI. The primary outcome was visual analog scale (VAS) pain score on postoperative day (POD) 1, and secondary outcomes included VAS and opioid consumption on each POD, hospitalization cost, length of stay, and discharge acuity. RESULTS: The mean VAS and opioid consumption (MME) were significantly lower in the treatment group than that in the control group on POD 1, with VAS difference -1.10 (95% confidence interval, -1.64 to -0.55), false discover rate corrected (P<0.001), and MME difference -26.19 (95% confidence interval, -39.16 to -13.23, P<0.001). A significant difference was also found for both VAS (P=0.007) and opioid consumption (P=0.018) on POD 2 and for opioid consumption on POD 3 (P=0.008). Length of stay (days) in the control group versus the treatment group was 2.50±1.38 versus 1.36±0.95 (P=0.002), and the total cost of hospitalization was over 20% higher in the control group than that in the treatment group (P=0.002). DISCUSSION: The addition of transmuscular quadratus lumborum and lateral femoral cutaneous nerve block in total hip arthroplasty provides improved analgesia indicated by lower pain scores and opioid reduction and accelerated recovery with shorter hospitalization and decreased hospitalization cost.

Perioperative Considerations for a Patient with a Left Ventricular Assist Device Undergoing Thyroidectomy.

As the population ages, ventricular assist devices (VADs) are becoming more prevalent, even in the outpatient perioperative setting. Patients with VADs present unique challenges for the anesthesiologist, who needs to have a thorough understanding of device physiology and design an appropriate anesthetic plan. This case report demonstrates an alternative monitored anesthesia care (MAC) anesthetic technique for a patient with a left VAD undergoing total thyroidectomy. This alternative provided a safe comfortable anesthetic and can be used successfully in patients with circulatory support devices.

Medial Oblique Meniscomeniscal Ligament of Knee.

An aberrant meniscus attachment was found in the setting of an anterior cruciate ligament injury. An anomalous cordlike attachment ran from the anterior horn of the medial meniscus to the posterior horn of the lateral meniscus through the intercondylar notch. Surgeons should be aware of the anatomical variability in the knee in order to provide the best care for their patients.

Does Gracilis Preservation Matter in Anterior Cruciate Ligament Reconstruction? A Systematic Review.

PURPOSE: To analyze the effect of gracilis harvest on hamstring strength, patient-reported outcomes, and anterior knee laxity after anterior cruciate ligament (ACL) reconstruction. METHODS: A systematic review of the literature was performed to identify studies comparing the results of semitendinosus (ST) versus semitendinosus-gracilis (ST-G) harvest for ACL reconstruction. A meta-analysis using a random effects model was performed to determine overall pooled estimates of effect for the influence of additional gracilis harvest on hamstring strength, patient-reported outcomes, and anterior knee laxity after ACL reconstruction. RESULTS: Twelve studies were identified and included in the review. ST-G harvest was noted to decrease hamstring isokinetic strength at 60° per second by 3.85% relative to isolated ST harvest (P = .01). Decreased isometric strength was also noted in the ST-G harvest group at both 90° of flexion (mean difference: 5.55%; P = .03) and 105° to 110° of flexion (mean difference: 13.68%; P = .003). Active knee flexion angle loss was also noted to be greater in the ST-G harvest group (mean difference: 3.91°; P = .006). No differences were found in isokinetic strength at 180° to 240° per second (mean difference: 3.20%; P = .08), patient-reported outcome scores (mean difference: 1.87 points; P = .06), or anterior knee laxity (mean difference: 0.03 mm; P = .78) based on gracilis harvest. CONCLUSIONS: The addition of gracilis harvest to an isolated ST harvest for ACL reconstruction results in statistically significant, but likely not clinically relevant differences in isokinetic and isometric hamstring strength as well as patient-reported outcomes. Hamstring strength deficits may be larger at higher flexion angles. LEVEL OF EVIDENCE: Level III, systematic review of level I-III studies.

The Relationship between Body Mass Index and Risk of Failure following Meniscus Repair.

It is unknown whether body mass index (BMI) influences outcomes of meniscus repair. We hypothesized that increased BMI would be associated with increased risk of failure. A retrospective study was performed involving patients who had undergone meniscus repair between 2008 and 2012. Chart review and phone interviews were conducted to determine which patients required additional surgery. Patients were categorized as normal BMI (<25) or increased BMI (≥25). Of the 305 patients who met study criteria, 216 (70.8%) were available for follow-up at a mean of 19 months postoperatively. A total of 100 patients (46.3%) had a BMI <25 and 116 (53.7%) patients had a BMI ≥25. BMI was less than 35 in 90% of patients. Thirty-four patients (15.7%) required further surgery for a repair failure. Failure occurred in 20 patients (20%) in the normal BMI group and 14 patients (12%) in the increased BMI group (p = 0.14). Logistic regression revealed a trend toward decreased odds of repair failure in the increased BMI group (odds ratio: 0.46; 95% confidence interval: 0.20-1.05; p = 0.065). Patients with a BMI ≥25 did not have a higher risk of meniscus repair failure relative to those with a BMI <25. Given these findings, surgeons should not consider moderately increased BMI as a contraindication to meniscal repair. The effect of BMI greater than 35 on outcomes of meniscal repair remains unclear and warrants further study.