[Effect of the antioxidant ionol on myocardial energy metabolism and the course of traumatic shock]. / Vliianie antioksidanta ionola na énergeticheskii metabolizm miokarda i techenie travmaticheskogo shoka.

Energy metabolism was studied in experiments on rats with due regard for the individual features of the organism's reaction to trauma. The animals were divided into 2 subgroups according to the survival period during the experiment. Disorders of mitochondrial function were revealed in both subgroups, but they differed in degree according to the severity of the process. Preliminary injection of the antioxidant ionol prolonged the animals' survival and prevented disorders of mitochondrial function. The article discusses the possibility of preventing activation of free-radical oxidation of the membrane lipids and removal of their damaging effect on the mitochondria with ionol.

[Effect of dalargin on energy metabolism of heart contractile function in acute blood loss]. / Vliianie dalargina na énergoobespechenie sokratitel'noi funktsii serdtsa pri ostroi krovopotere.

The authors studied the mechanisms of disorders of energy provision of myocardial contractility in rabbits in hemorrhagic shock and appraised the efficacy of a new Soviet-produced agent dalargin possessing an antiadrenergic property. It is shown that dalargin exerts a significant effect on the condition of the cardiovascular system and the function of the myocardial mitochondria (MC). The effect differed depending on the time of the injection and the condition of the organism. Increase of the heart contractive function, improvement of MC function, and prolonged survival of the animals were encountered only in rabbits who received dalargin 30 minutes after blood loss. The mechanisms of the effects of dalargin in acute blood loss are discussed.