[Organofluorine derivatives of amphotericin B: synthesis and antifungal activity]. / Ftororganicheskie poizvodnye amfoteritsina B: sintez i protivogribkovaia aktivnost'.

Reactions of amphotericin B, a polyene macrolide antibiotic, with acyl perfluorides resulted in formation of its N-perfluoroacyl derivatives. Physicochemical and medicobiological properties of the derivatives were studied. The biological study revealed that the acute toxity (LD50) of the derivatives was 2 times as low as that of the starting antibiotic. The derivatives showed high antifungal activity against a great number of the test cultures.

[Synthesis and biological activity of aminophenylphosphonic derivatives of levorin]. / Poluchenie i biologicheskaia aktivnost' aminofenilfosfonistykh proizvodnykh levorina.

Reactions of levorin, a polyenic macrolide antibiotic, with aromatic aldehydes and hypophosphorous acid resulted in formation of its amino phenylphosphonium derivatives. Physicochemical and biological properties of the derivatives were studied. The levorin amino phenylphosphonium derivatives were shown to be low toxic and have antifungal and antiviral activities.