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Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients.
Vishweshwar, Peddy; McMahon, Jennifer A; Peterson, Matthew L; Hickey, Magali B; Shattock, Tanise R; Zaworotko, Michael J.
Chem Commun (Camb) ; (36): 4601-3, 2005 Sep 28.
Article in English | MEDLINE | ID: mdl-16158128

ABSTRACT

The carboxylic acid-primary amide supramolecular heterosynthon is exploited for the generation of pharmaceutical co-crystals that contain two active pharmaceutical ingredients that are polymorphic in their pure forms.


Subject(s)
Crystallization , Pharmaceutical Preparations/chemical synthesis , Crystallography, X-Ray , Indicators and Reagents , Models, Molecular , Molecular Conformation , Nootropic Agents/chemical synthesis , Nootropic Agents/chemistry , Piracetam/chemical synthesis , Piracetam/chemistry
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