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Bioorg Med Chem Lett
; 11(10): 1257-60, 2001 May 21.
Article
in English
| MEDLINE
| ID: mdl-11392531
ABSTRACT
Imidazolemethyl diaryl ethers are potent inhibitors of farnesyl-protein transferase. The SNAr displacement reaction used to prepare these diaryl ethers was amenable to rapid parallel synthesis of FPTase inhibitors. The use of a broad range of commercially available phenols quickly identified compounds which proved active in cells.