ABSTRACT
Erythron membrane impairment was investigated using membrane -active drugs (obsidan, delagil, morphium, ethanol) to specify indications to acupuncture in bronchial asthma (BA). The patients were studied during the treatment and followed up for a year. It was found that both immediate and long-term results of acupuncture were related to patterns of the membrane impairment. BA patients with a sharp, greater than 1.5 fold diminution of microcyte count upon delagil test should be assigned to repeated courses of acupuncture during a year. To monitor the treatment effect, it is recommended to define osmotic resistance of the red blood cells in obsidan test in addition to clinicofunctional indices.
Subject(s)
Acupuncture Therapy , Adrenal Cortex Hormones/therapeutic use , Asthma/therapy , Adult , Asthma/blood , Combined Modality Therapy , Female , Humans , Male , Middle Aged , Time FactorsABSTRACT
The following bronchial provocation tests were carried out: 310 with acetylcholine, 216 with submaximal physical exercise, 246 with cold air inhalation, and 103 with aspirin in healthy subjects, relatives of bronchial asthma patients, in patients with preasthma and asthma in a stage of exacerbation abatement or remission. Based on the data obtained the authors show nonspecific hyperreactivity of the bronchi in healthy relatives of bronchial asthma patients, heterogeneity and a high incidence of responses to acetylcholine, cold air and physical exercise, augmentation of the reaction intensity to different stimuli in all asthma patients. The follow-up of bronchial hyperreactivity discovered its progression in the absence of the treatment and the lowering of its intensity as a result of the treatment with calcium antagonists, magnesium sulfate, punctate massage, sublaminal physical exercise, ultraviolet radiation of autologous blood, specific desensitization with aspirin.
Subject(s)
Asthma/physiopathology , Bronchial Hyperreactivity/diagnosis , Acetylcholine , Aspirin , Asthma/epidemiology , Asthma/therapy , Bronchial Hyperreactivity/epidemiology , Bronchial Hyperreactivity/therapy , Bronchial Provocation Tests/methods , Cold Temperature , Combined Modality Therapy , Dose-Response Relationship, Drug , Exercise Test , Humans , Risk FactorsABSTRACT
In 46 bronchial asthma (BA) patients, a study was made of the effects of calcium antagonists (CA) (corinfar, perdipine) on bronchial sensitivity and reactivity determined on bronchospasm induction with the increasing doses of acetylcholine. A single intake of 20 mg of a CA in BA patients significantly improved bronchial sensitivity and reactivity (the rise of the PD25 and the decline of the alpha angle). 20 patients were treated with corinfar for two weeks after administration of the basic therapy. As a result, the clinical status as well as bronchial sensitivity and reactivity improved in the majority of BA patients. While assessing the efficacy of the treatment with corinfar after half a year it was established that in 9 out of 13 BA patients, the PD25 increased and the alpha angle diminished. Thus, CA reduce bronchial hypersensitivity and hyperreactivity to acetylcholine in BA patients.
Subject(s)
Asthma/drug therapy , Bronchi/drug effects , Calcium Channel Blockers/therapeutic use , Acetylcholine , Adult , Asthma/physiopathology , Bronchi/physiopathology , Bronchial Provocation Tests/instrumentation , Bronchial Provocation Tests/methods , Bronchodilator Agents/administration & dosage , Dose-Response Relationship, Drug , Drug Evaluation , Humans , Nifedipine/administration & dosageABSTRACT
The authors review potential approaches to the upgrading of the diagnosis at the out- and inpatient stages of the rendering medical assistance to patients suffering from bronchial asthma (BA). Show the necessity of the counselling specialized aid, additional studies of the signs of atopy, wise combination of non- and medicamentous treatment methods to enhance the efficacy of the treatment of BA patients. Provide evidence for the advisability of solving the organizational problems concerned with a closer interaction of the polyclinic and hospital with the leading medical institutions on the problem "Pathology of the Respiratory Organs".
