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Med Tr Prom Ekol ; (8): 15-8, 1997.
Article in Russian | MEDLINE | ID: mdl-9377047

ABSTRACT

The article presents studies of hormonal state in rats under daily or 20-day peroral administration of variable doses of 2,4-D herbicide containing dioxine. Changed levels of thyroid hormones, insulin, cortisol, testosterone and estradiol appeared to be divergent and dose-dependent, proving direct toxic effects of the herbicide in endocrine organs, altered hormonal effects in target organs and disorders of peripheral hormonal metabolism.


Subject(s)
2,4-Dichlorophenoxyacetic Acid/poisoning , Dioxins/poisoning , Herbicides/poisoning , Hormones/analysis , Acute Disease , Animals , Dose-Response Relationship, Drug , Endocrine Glands/chemistry , Endocrine Glands/drug effects , Lethal Dose 50 , Male , Poisoning/metabolism , Rats
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