[The geriatric status in patients with the breast cancer in the conditions of comorbidity.]

The article represents the results of a comparative analysis of the geriatric status, the Charlson comorbidity index and the geriatric variant of the cumulative illness rating scale for geriatrics (CIRS-G) in patients of different age groups with breast cancer, considering the concomitant pathology (CHF). It was revealed that the age classification of the WHO is more valid in determining the somatic and geriatric status of women with breast cancer. Also the evaluation of the severity of geriatric syndromes is given. It was revealed that the malnutrition syndrome and cognitive impairment syndrome are more expressed in people of middle age and elderly with breast cancer As well the importance of detecting both frailty and comorbidity is determined with the aim of increasing the accuracy of prediction of adverse events of treatment.

[Melatonin in the combined treatment of cardiovascular diseases].

The aim of the work was to assess effectiveness of melatonin monotherapy (MT) and combined treatment (CT) in aged patients with arterial hypertension (AH) and coronary heart disease (CHD). A group of 170 patients (mean age 64 years) included 61 ones with CHD and 100 with AH. ECG, AP, and echoCG monitoring was performed before and 21 days after treatment along with clinical examination and evaluation of oxidative and antioxidative activities in erythrocytes. Treatment efficiency was compared in the study and randomized control groups. The data obtained suggest antihypertensive action of MT. CT with melatonin and antihypertensive drugs had better outcome than standard therapy in control groups. Inclusion of melatonin in CT of CHD produced marked anti-ischemic and anti-anginal effects and normalized oxidant/antioxidant balance. It is concluded that melatonin should be an important component of MT and CT of cardiovascular diseases.

[Melatonin in combined therapy of patients with stable angina and arterial hypertension].

Study of 2 randomized groups of patients with coronary heart disease, stable exertional angina combined with arterial hypertension, receiving traditional treatment and combined therapy with inclusion of melatonin, was performed. All patients (43 persons at the age from 44 to 69 years) before and after treatment underwent daily monitoring of arterial pressure (AP) by system "BR-102 Schiller", Switzerland. As a result of study, in the group of traditional treatment positive dynamics such as significant decrease in average daily values of systolic arterial pressure (SAP) from 159.7 +/- 3.4 to 146.1 +/- 4.6 (p = 0.02), diastolic arterial pressure (DAP) from 92.7 +/- 1.2 to 88.6 +/- 1.3 (p = 0.03), average daytime AP indices, average nighttime SAP indices, was noticed. SAP and DAP variability was significantly decreased only at daytime from 23.1 +/- 1.7 to 18.8 +/- 1.4 (p = 0.05) and from 18.1 +/- 0.5 to 16.5 +/- 0.4 respectively. Insufficient decrease in SAP and DAP at nighttime was detected. Inclusion of melatonin in traditional therapy leaded to more expressed decrease in average daily, daytime and nighttime AP indices and significant decrease in load by pressure value (SAP and DAP time indices were significantly reduced both at daytime and at nighttime). Degree of SAP and DAP nighttime decrease initially was upon the average 8.1 +/- 1.1% and 7.0 +/- 1.0% respectively (non-dippers), and after combined treatment was 13.4 +/- 0.9% (p = 0.003) and 11.0 +/- 1.1% (dippers), which proved recovery of normal daily AP profile. Significant decrease in SAP variability at daytime from 22.3 +/- 1.8 to 15.1 +/- 1.2 (p = 0.003), at nighttime from 16.1 +/- 1.4 to 12.7 +/- 1.0 (p = 0.05) in DAP variability at daytime from 17.5 +/- 0.4 to 14.5 +/- 0.4 (p < 0.001), at nighttime from 13.1 +/- 0.7 to 11.1 +/- 0.7 (p = 0.05).

[ECG and BP monitoring in patients with stable angina and essential hypertension on therapy with monocinque].

The authors studied ECG and arterial pressure (AP) parameters in 24 patients with stable angina and arterial hypertension aged 57.9 +/- 1.6 years, receiving 14-day complex therapy including administration of monocinque in a dose of 20 mgs 2 times a day. A portable Digitrak-Plus Zymed Holter 1810 device (USA) was used to monitor ECG, and a portable Meditech ABPM-04 device (Hungary)--to monitor AP. The therapy substantially reduced episode frequency as well as total length and amplitude of ST segment depression. At the same time, the patients displayed decrease of day and night systolic and diastolic AP, as well as of their mean daily values.