[Mechanism of hematuria in hematuric nephritis]. / Mekhanizm gematurii pri gematuricheskikh nefritakh.

Peripheral blood erythrocytic functional disorders were studied in 31 patients with primary and secondary hematuric nephritides. A decrease in erythrocyte normal charge was noted in 90%, erythrocyte fragmentation in 43%. Reverse correlation was established between a degree of lowered peripheral blood erythrocyte charge and serum IgA concentration (R = -0.65 +/- 0.15). The role of the detected erythrocytic disorders in the mechanisms of hematuria, the involvement of local (renal) intravascular coagulation in the pathogenesis of hematuric nephritides were discussed.

[Clinico-morphological features and the course of glomerulonephritis in hemorrhagic vasculitis]. / Kliniko-morfologicheskie osobennosti i techenie glomerulonefrita pri gemorragicheskom vasculite.

Peculiarities of a clinical course and prognosis of glomerulonephritis in Schönlein-Henoch disease (SH-nephritis) were studied in 42 adult patients. The 5- and 10-year survival rates were 87% and 72%, respectively. Of unfavorable prognostic value were proteinuria over 1 g/l, nephrotic syndrome, particularly combined with hypertension, marked stable microhematuria, and the detection of diffuse fibroplastic, extracapillary, and mesangiocapillary nephritis on biopsy. SH-nephritis was characterized by a more severe course in male patients, in persons aged over 30, and in the involvement of the kidneys one year and more after the appearance of the first clinical signs of skin vasculitis. The level of blood serum IgA and the gravity of skin vasculitis had no prognostic importance.