1.
A convenient and efficient approach to polyfluorosalicylic acids and their tuberculostatic activity.
Bioorg Med Chem Lett
; 26(10): 2455-2458, 2016 05 15.
Article
in English
| MEDLINE
| ID: mdl-27072906
ABSTRACT
We have developed the practical method for polyfluorosalicylic acids synthesis via nucleophilic ortho-mono-substitution of fluorine atom with magnesium methoxide. We have managed to increase the yield of targeted polyfluorosalicylic acids from good to quantitative. We have studied the tuberculostatic activity of polyfluorosalicylic acids. It has been found that minimum inhibitory concentration (MIC) of compounds is from 0.7 to 6.5µg/mL depending on the structure.