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1.
Eksp Onkol ; 12(2): 36-8, 1990.
Article in Russian | MEDLINE | ID: mdl-1690633

ABSTRACT

The system of proteolytic enzymes and their inhibitors was studied in tissues of ovarian tumours of Wistar rats. It has been revealed that activation of proteolysis enzymes is observed in the genesis of tumour growth against a background of the absence of protease inhibitors. The correction of revealed disturbances by introducing the inhibitors of proteolytic enzymes and hormone preparations has shown that contrical and norcolute are the most effective. The results obtained suggest the further search of preparation normalizing the condition of the given system.


Subject(s)
Ovarian Neoplasms/etiology , Peptide Hydrolases/metabolism , Protease Inhibitors/metabolism , Animals , Antineoplastic Agents/administration & dosage , Aprotinin/administration & dosage , Chlormadinone Acetate/administration & dosage , Contraceptives, Oral, Combined/administration & dosage , Drug Combinations , Drug Screening Assays, Antitumor , Female , Granulosa Cell Tumor/drug therapy , Granulosa Cell Tumor/enzymology , Granulosa Cell Tumor/etiology , Neoplasm Transplantation , Norethindrone/administration & dosage , Ovarian Neoplasms/drug therapy , Ovarian Neoplasms/enzymology , Ovariectomy , Rats , Rats, Inbred Strains , Thecoma/drug therapy , Thecoma/enzymology , Thecoma/etiology
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