ABSTRACT
OBJECTIVE: To study the possibility of the modern CT and MRI methods in diagnostics of the orbital venous varices (OVV), discover the special characteristics of these lesions concerning their hemodynamic and differential diagnosis with other orbital lesions. MATERIAL AND METHODS: In the period from 2012 to 2019 ten patients with OVV were evaluated. Four of them were men, three - women and three - children (boys aged 7, 10, and 12 years). Age of the patients varied from 7 to 75 years old (mediana - 34).CT was performed on 9 patients using low dose protocol with injecting the contrast in standard position (supine) and in the prone position. CT-angiography was performed on 3 patients and CT-perfusion - 5 patients which allowed the assessment of the blood supply and quantitative lesions hemodynamic by calculating blood flow (BFOVV), blood volume (BVOVV) and mean transit time (MTTOVV).MRI with contrast injection and Fat Sat technology was performed on 9 patients, 3 of them were both in the supine and prone positions. 4 patients were evaluated by bolus MR-angiography (TRICKS). RESULTS: The majority of the OVV was localized in the medial compartments and apex of the orbit. Left sided lesions were found in 6 cases, right - 3. One patient had both sided OVV. In one of the cases in 10-year-old child, we revealed malformation of the Galen vein associated with bilateral varicose enlargement of the intraorbital veins (secondary OVV).In CT studies all of the lesions enhanced after the contrast injection. When the patients were study in the prone position, all lesions were enlarging; which lead to the diagnosis of OVV. CT-angiography (venous blood flow) proved vascular nature of the lesions. While studying the quantitative lesion hemodynamic by the CT perfusion technology, it was discovered, that OVV tend to have high blood volume (BVOVV=19.61±3.23(ml/100g) and high blood flow (BFOVV= 60.87±8.11) and the prolongation of mean transit time (MTTOVV=19.23±3.07). Normal parameters measured in white matter were CBVN=1.37±0.69(ml/100g), CBFN=38.4±4.31(ml/100g/min), MTTN=2.89±0.44s.In MRI studies all the lesions had iso-hypointense MR-signal on T1- and hyperintense on T2-images. The pattern of contrast enhancement was inhomogeneous, however reaching homogeneity after some time. TRICKS MR-angiography was more sensitive than CT-angiography (venous phase). Moreover, the absence of radiation exposition was an additional advantage of the MR-venography. CONCLUSION: Diagnosis of orbital vascular pathology requires an understanding of the classification of vascular lesions, the integration of the patient's medical history with epidemiological data, as well as a through analysis of the results of instrumental diagnostic methods. CT or MRI, including scanning in the prone position, as well as minimally invasive CT- and MR-TRICKS-angiography and ophthalmological studies of the patient, determine a comprehensive approach to the diagnosis and selection of adequate treatment for orbital venous varices.In the differential diagnosis of OVV with other neoplasms of the orbit, we recommend CT-perfusion study with determine the quantitative characteristics of its hemodynamics.
Subject(s)
Magnetic Resonance Imaging , Varicose Veins , Adolescent , Adult , Aged , Child , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Orbit , Tomography, X-Ray Computed , Varicose Veins/diagnosis , Young AdultABSTRACT
MATERIAL AND METHODS: In the period from 2010 to 2016. 14 patients with cavernous hemangioma (CH) and 2 patients with capillary hemangioma (CapH) of the orbit were examined. The age of CH patients varied from 17 to 67 years (median, 53 years); 8 females and 6 males. The age of CapH patients was 35 and 54 years. All patients underwent surgery with subsequent histological verification. CT-perfusion was performed in 10 CH patients and 2 CapH patients according to a developed low-dose protocol (80 kV, 200 mAs, tscan=40 s) with allowance for a target localizer (80 kV, 120 mAs) and at a maximum radiation dose of not more than 4.0 mZv. Neoplasm microcirculation was quantitatively assessed by calculating hemodynamic parameters: blood flow velocity (BFV), blood volume (BV), and mean transit time (MTT). MRI without and with contrast enhancement was performed in 11 CH patients and 2 CapH patients according to the ophthalmologic protocol (Signa GE, 3.0 T) accepted at the Institute: without contrast enhancement - T1, T2, and T2-FLAIR modes, T1 and T2 with a Fat Sat technique at a scan thickness of 3 mm, and DWI MRI; contrast enhancement - T1 (three projections) mode, including the Fat Sat technique. SWAN (n=2) and non-contrast MR perfusion ASL (n=3) were also used. Diffusion-weighted images (DWI) were processed with calculation of the apparent diffusion coefficient (ACD). RESULTS: In all CH patients, CT-perfusion revealed low perfusion parameters of blood flow: BVCH=0.86±0.37 mL/100 g, BFVCH= 4.89±2.01 mL/100 g/min with a high mean transit time MTTCH=10.13±3.05 s compared to the same parameters of blood flow in the normal white matter: CBVNormWM=1.63±2.22 mL/100 g, CBFVNormWM=9.72±3.13 mL/100 g/min, and MTTNormWM=6.76±2.78 s. In CapH cases, significantly increased blood flow velocity and volume values and a low MTT value in the tumor were observed: BVCapH=10.30±4.10 mL/100 g, BFVCapH=119.72±53.13 mL/100 g/min, and MTTCapH=4.35±1.79 s. In the case of orbital hemangiomas, optimal MRI modes were T1 and T2 with the Fat Sat technique, a scan thickness of 3 mm, and intravenous contrast enhancement. The revealed pattern of contrast agent accumulation by CH, initially in the central part and then in the periphery, may be a useful radiographic sign in the differential diagnosis with other orbital tumors. CONCLUSION: Modern CT- and MRI-based diagnostics of orbital hemangiomas provides not only the exact location, size, and spread of the lesion but also reveals the characteristic structural features of these tumors, and the use of perfusion techniques visualizes hemodynamics of the tumors. CT-perfusion-based hemodynamic parameters of cavernous hemangiomas typical of this type of hemangiomas may be used in the differential diagnosis with other tumors of this location. The use of contrast enhancement and the Fat Sat technique with a scan thickness of not more than 3 mm is optimal for MRI diagnostics of orbital hemangiomas.
Subject(s)
Hemangioma, Capillary/diagnostic imaging , Hemangioma, Cavernous/diagnostic imaging , Orbit/diagnostic imaging , Orbital Neoplasms/diagnostic imaging , Adult , Blood Flow Velocity , Diagnosis, Differential , Diffusion Magnetic Resonance Imaging , Female , Hemangioma, Capillary/blood supply , Hemangioma, Cavernous/blood supply , Humans , Magnetic Resonance Imaging , Male , Microcirculation , Middle Aged , Orbit/blood supply , Orbital Neoplasms/blood supply , Tomography, X-Ray ComputedABSTRACT
Glomus jugulare tumors (GJT) (AKA paraganglioma or chemodecroma) make 0.6% of head and neck tumors and 80% of jugular foramen lesions. Recently different types of stereotactic radiotherapy are actively used in their treatment. The given paper summarizes our first experience of using CyberKnife system in management of patients with paragangliomas. Since April 2009 till September 2011 34 patients with GJT were treated in department for radiation therapy of Burdenko Neurosurgical Institute using CyberKnife system. Mean age was 50.5 years (range 26-75 years). Mean volume of treated lesions was 14.6 +/- 10.96 cm3 (range--1.04-37.4 cm3). Stereotactic radiosurgery was performed in 4 patients. Mean prescribed dose was 17 +/- 3.1 Gy (13.7-22 Gy). 30 patients received hypofractionation treatment (3-7 fractions with total dose 18-35 Gy). Mean follow-up period in our series was 8 months (1-20 months). Control of tumor growth reached 100% because none of the patients needed any additional therapy (microsurgical resection or repeated radiotherapy). Persistent trigeminal neuropathy was observed in 1 case (5%). There were no constant impairment of VII, IX, X, XII and XIII cranial nerves in the series. Stabilization of auditory function was present in 9 (82%) of 11 patients with initially preserved hearing. Preservation of effective hearing was observed in 75% of patients. Stereotactic radiosurgery and hypofractionation using CyberKnife system are effective modalities in management of such complex neurosurgical disease as GJT. Neurological deterioration after radiation treatment is extremely rare and in most cases is transient.
